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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Univentricular Heart Clear all
Active, not recruiting Phase 2 Interventional Results available

Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome

NCT03779711
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Autologous (self) mononuclear cells derived from umbilical cord blood, Stage II Surgical repair
Biological · Procedure
Lead sponsor
Timothy J Nelson, MD, PhD
Other
Eligibility
Up to 12 Months
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
8
States / cities
Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational

Biomarker Study for Heart Failure in Children With Single Ventricle Physiology

NCT00571233
View directory record Official record
Conditions
Tricuspid Atresia, Hypoplastic Left Heart Syndrome, Unbalanced AV Canal
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
1 Month to 6 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Phase 1 Interventional

A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery

NCT01034007
View directory record Official record
Conditions
Single Ventricle Cardiac Anomaly
Interventions
Tissue Engineered Vascular Grafts
Combination Product
Lead sponsor
Christopher Breuer
Other
Eligibility
1 Year to 100 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 1, 2018 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Early Use of Vasopressin in Post-Fontan Management

NCT03088345
View directory record Official record
Conditions
Circulatory Perfusion Disorder, Congenital Heart Disease, Single-ventricle
Interventions
Vasopressin, Arginine, Placebo
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
3 Weeks to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Jul 24, 2026, 4:06 AM EDT
Terminated Phase 4 Interventional Results available

The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease

NCT01971593
View directory record Official record
Conditions
Tetralogy of Fallot, Transposition of the Great Vessels With an Arterial Switch, Single Ventricle With a Fontan Palliation
Interventions
Eplerenone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Jul 24, 2026, 4:06 AM EDT
Terminated No phase listed Observational

Characterizing the Effect of Dopamine on Markers of Lymph Re-circulation in Fontan-associated Protein-losing Enteropathy

NCT03322345
View directory record Official record
Conditions
Dopamine, Protein-Losing Enteropathies, Lymphatic System, Lymph, Catecholamine, Single-ventricle, Congenital Heart Disease
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
3 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Phase 2 Interventional Results available

Ambrisentan in Single Ventricle

NCT02080637
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome, Hypoplastic Right-sided Heart Complex
Interventions
Ambrisentan, Placebo
Drug · Other
Lead sponsor
Kevin Hill
Other
Eligibility
24 Months to 120 Months
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Jul 24, 2026, 4:06 AM EDT
Recruiting Phase 1 Interventional

IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease

NCT06324396
View directory record Official record
Conditions
Fontan Circulation
Interventions
Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years)
Drug
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
8 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 1, 2026 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational

Fontan Imaging Biomarkers (FIB) Study

NCT03119090
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Not applicable Interventional

Enhanced External Counterpulsation in Patients With Fontan Circulation

NCT04956952
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
EECP
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Jul 24, 2026, 4:06 AM EDT
Not yet recruiting No phase listed Observational

Occlutech AFR Fontan Study

NCT07532369
View directory record Official record
Conditions
Failure of Fontan Type Circulation, Fenestration, Univentricular Heart, Congenital Anomaly
Interventions
Occlutech Atrial Flow Regulator Retrospective Data Collection
Device
Lead sponsor
Occlutech International AB
Industry
Eligibility
Not listed
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
7
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational

Cardiac Biomarkers in Patients With Single Ventricle Physiology

NCT03678909
View directory record Official record
Conditions
Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
Interventions
Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 2 Months
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Jul 24, 2026, 4:06 AM EDT
Recruiting No phase listed Observational

Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity

NCT07073612
View directory record Official record
Conditions
Single-ventricle, Stenosis
Interventions
Cardiopulmonary Exercise Testing (CPET), Shear Wave Elastography Scan
Diagnostic Test
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
12 Years to 21 Years
Enrollment
20 participants
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 24, 2026, 4:06 AM EDT
Terminated No phase listed Observational

NIRS Monitoring in the Ambulatory Single Ventricle Patient

NCT00166218
View directory record Official record
Conditions
Ambulatory Children With Single Ventricle
Interventions
near-infrared spectroscopy
Device
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 26, 2013 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Frailty in Children With Cardiac Disease

NCT02999438
View directory record Official record
Conditions
Pulmonary Hypertension, Heart Failure, Single Ventricle
Interventions
Actigraph to check activity levels at home
Device
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
8 Years to 18 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Not applicable Interventional Results available

Endothelin Blockade in Patients With Single Ventricle Physiology

NCT00989911
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Bosentan
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2015 · Synced Jul 24, 2026, 4:06 AM EDT
Not listed No phase listed Observational

Biomarkers for Feeding Intolerance in Infants With Complex Congenital Heart Defects Undergoing Single Ventricle Staged Palliation

NCT02995577
View directory record Official record
Conditions
Single Ventricle Physiology
Interventions
Feeding tolerant, Feeding intolerant, Necrotizing enterocolitis
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
1 Day to 3 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2016 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational

Genetic Determinants of Congenital Heart Disease Outcomes

NCT01656941
View directory record Official record
Conditions
Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, d-Transposition of the Great Arteries
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
Up to 30 Days
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Atlanta, Georgia • Ann Arbor, Michigan • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced Jul 24, 2026, 4:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Nutritional Failure in Infants With Single Ventricle Congenital Heart Disease

NCT01821287
View directory record Official record
Conditions
Congenital Heart Disease, Nutritional Failure
Interventions
CHD
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 12 Months
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 13, 2014 · Synced Jul 24, 2026, 4:06 AM EDT
Recruiting Phase 1Phase 2 Interventional

PK/PD of Digoxin in Infants With SVHD

NCT06613477
View directory record Official record
Conditions
Single-ventricle, Infant Conditions, Infant, Newborn, Diseases, Infant, Premature, Diseases
Interventions
PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease
Drug
Lead sponsor
Duke University
Other
Eligibility
30 Days to 6 Months
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Durham, North Carolina • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Not applicable Interventional Results available

Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan

NCT05634226
View directory record Official record
Conditions
Single-ventricle
Interventions
Hands-free oral-positive pressure device (oPEP)
Device
Lead sponsor
Tarek Alsaied
Other
Eligibility
8 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced Jul 24, 2026, 4:06 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Use of Vasopressin Following the Fontan Operation

NCT02975999
View directory record Official record
Conditions
Pleural Effusion, Single-ventricle
Interventions
Vasopressin, Normal Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Months to 7 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 24, 2026, 4:06 AM EDT
Recruiting No phase listed Observational

Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

NCT06434207
View directory record Official record
Conditions
Congenital Heart Disease, Single-ventricle, Thrombosis
Interventions
Collecting discarded blood samples
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Day to 7 Days
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Jul 24, 2026, 4:06 AM EDT
Recruiting Phase 2 Interventional

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

NCT04467671
View directory record Official record
Conditions
HLH - Hypoplastic Left Heart Syndrome, DORV, DILV - Double Inlet Left Ventricle, Mitral Atresia, Tricuspid Atresia, Unbalanced AV Canal, Single-ventricle, Heart Defects, Congenital, Cardiovascular Abnormalities, Cardiovascular Diseases, Heart Diseases
Interventions
Tissue Engineered Vascular Grafts
Combination Product
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Jul 24, 2026, 4:06 AM EDT