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ClinicalTrials.gov public records Last synced Jul 21, 2026, 9:41 PM EDT

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Showing 1–24 of 206 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Varicose Veins Clear all
Recruiting Phase 2 Interventional

MTX-001 for the Treatment of Non-Healing Venous Stasis Ulcers

NCT04647240
View directory record Official record
Conditions
Venous Stasis Ulcer, Venous Leg Ulcer
Interventions
MTX-001 (human amniotic fluid)
Biological
Lead sponsor
Merakris Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
11
States / cities
Tucson, Arizona • Castro Valley, California • Fresno, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Not applicable Interventional

A Study of Soundscapes for Patient Wellbeing

NCT05650073
View directory record Official record
Conditions
Varicose Veins
Interventions
Immersive soundscapes
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 21, 2026, 9:41 PM EDT
Not listed Not applicable Interventional

Clinical Study Of Affinity Versus SOC In The Management Of VLUs

NCT04901013
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Affinity
Other
Lead sponsor
Organogenesis
Industry
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2021 · Synced Jul 21, 2026, 9:41 PM EDT
Not listed Not applicable Interventional

Direct Application of Integra Bilayer Matrices on Bare Calvarium Without Preliminary Burring

NCT05311124
View directory record Official record
Conditions
Wound Care, Pressure Ulcer, Venous Ulcer, Surgical Wound, Trauma Wounds, Draining Wound
Interventions
Integra Dermal Regeneration template (IDRT)
Device
Lead sponsor
Joshua Choo
Other
Eligibility
55 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Jul 21, 2026, 9:41 PM EDT
Terminated Not applicable Interventional Results available

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

NCT03820947
View directory record Official record
Conditions
Venous Reflux
Interventions
VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
Device · Procedure
Lead sponsor
Medtronic Endovascular
Industry
Eligibility
18 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Prescott Valley, Arizona • Tucson, Arizona • Fresno, California + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Jul 21, 2026, 9:41 PM EDT
Completed No phase listed Observational

"Evaluation of the PillCam™ESO Capsule in the Detection of Esophageal Varices

NCT00481416
View directory record Official record
Conditions
Esophageal Varices
Interventions
PillCam Eso
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Enrollment
318 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
3
States / cities
Scottsdale, Arizona • Plymouth, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 3 Interventional Results available

Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial

NCT01224210
View directory record Official record
Conditions
Portopulmonary Hypertension
Interventions
Ambrisentan
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2020
U.S. locations
6
States / cities
La Jolla, California • Jacksonville, Florida • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Not applicable Interventional

Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers

NCT03629236
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
GrafixPL, Control
Other
Lead sponsor
Osiris Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Doral, Florida • Weymouth, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 2 Interventional Results available

Dose Finding Study of HP802-247 in Venous Leg Ulcers

NCT00852995
View directory record Official record
Conditions
Venous Leg Ulcer, Venous Stasis Ulcers
Interventions
HP802-247, Placebo (Vehicle)
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
29
States / cities
Tucson, Arizona • Castro Valley, California • Encinitas, California + 26 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2016 · Synced Jul 21, 2026, 9:41 PM EDT
Not listed Phase 2 Interventional

Study of VF001-DP in Patients With Chronic Venous Leg Ulcers

NCT02973893
View directory record Official record
Conditions
Ulcer, Leg Ulcer, Varicose Ulcer, Pathologic Processes, Skin Ulcer, Skin Diseases, Vascular Diseases, Cardiovascular Diseases
Interventions
Placebo, VF001-DP LD, VF001-DP HD
Biological
Lead sponsor
Factor Therapeutics Ltd.
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
17
States / cities
Carlsbad, California • Fresno, California • Laguna Hills, California + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers

NCT04817228
View directory record Official record
Conditions
Venous Leg Ulcer, Diabetic Foot Ulcer
Interventions
EscharEx (EX-02 formulation)
Drug
Lead sponsor
MediWound Ltd
Industry
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Tamarac, Florida • Las Vegas, Nevada • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Jul 21, 2026, 9:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Research Study Looking at Specific Tissue of the Umbilical Cord

NCT01166776
View directory record Official record
Conditions
Varices of Umbilical Cord
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
2
States / cities
Kansas City, Kansas • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jul 21, 2026, 9:41 PM EDT
Recruiting Not applicable Interventional

INNOVEN: Efficacy of Porcine Placental Extracellular Matrix Plus Standard of Care (SOC) Versus SOC Alone

NCT06606210
View directory record Official record
Conditions
Wound Heal, Venous Leg Ulcer
Interventions
InnovaMatrix® AC
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
North Port, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 1 Interventional

Preliminary Testing of New Treatment for Chronic Leg Wounds

NCT00000431
View directory record Official record
Conditions
Varicose Ulcer
Interventions
PDGF-B/Ad5
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2013 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Early Phase 1 Interventional

Taliderm Dressing for Venous Ulcers

NCT00720239
View directory record Official record
Conditions
Venous Stasis Ulcers, Venous Insufficiency
Interventions
Taliderm wound healing dressing
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
45 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2013 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Post Marketing Clinical Study Utilizing DermaStream and Saline in Venous Ulcers

NCT01129986
View directory record Official record
Conditions
Venous Stasis Ulcers
Interventions
DermaStream
Device
Lead sponsor
EnzySurge
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 3, 2013 · Synced Jul 21, 2026, 9:41 PM EDT
Withdrawn Phase 4 Interventional

Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs

NCT02988063
View directory record Official record
Conditions
Leg Ulcer, Veins, Varicose, Venous Ulcer, Reflux, Venous Reflux, Venous Leg Ulcer, Varicose Veins, Varicose Ulcer, Varicose Veins Leg
Interventions
Polidocanol Endovenous Microfoam (PEM)
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Jul 21, 2026, 9:41 PM EDT
Withdrawn Not applicable Interventional

Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting

NCT02936271
View directory record Official record
Conditions
Venous Insufficiency of Leg, Venous Reflux, Varicose Veins, Lower Extremity Edema Chronic
Interventions
Vasculera, Placebo
Other
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 22, 2022 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 3 Interventional

Prevention of Esophageal Varices by Beta-Adrenergic Blockers

NCT00006398
View directory record Official record
Conditions
Esophageal and Gastric Varices, Liver Cirrhosis, Portal Hypertension
Interventions
Timolol Maleate, Placebo
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 75 Years
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2002
U.S. locations
3
States / cities
New Haven, Connecticut • West Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 3 Interventional

Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding

NCT00331188
View directory record Official record
Conditions
Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
Interventions
Sanvar® (vapreotide)
Drug
Lead sponsor
Debiovision
Industry
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
19
States / cities
Birmingham, Alabama • Montgomery, Alabama • Scottsdale, Arizona + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2008 · Synced Jul 21, 2026, 9:41 PM EDT
Terminated Not applicable Interventional

An Open, Non-comparative, Multicenter Investigation to Evaluate the Safety and Performance of Exufiber Ag+, a Gelling Fiber Silver Dressing, When Used in Medium to High Exuding Chronic Wounds

NCT05494450
View directory record Official record
Conditions
Pressure Ulcer, Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
ExufiberAG+
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
2
States / cities
San Francisco, California • Miamisburg, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Jul 21, 2026, 9:41 PM EDT
Terminated Not applicable Interventional Results available

Efficacy Study of the Application of Low Level Laser Light to Treat Venous Stasis Ulcers

NCT01376050
View directory record Official record
Conditions
Venous Stasis Ulcer
Interventions
Erchonia ML Scanner (MLS), Placebo Laser
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
40 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2015 · Synced Jul 21, 2026, 9:41 PM EDT
Completed Phase 3 Interventional Results available

Endovenous Ablation With and Without Polidocanol Endovenous Microfoam Treatment for Patients With Great Saphenous Vein Incompetence and Visible Varicosities

NCT01197833
View directory record Official record
Conditions
Great Saphenous Vein Incompetence, Visible Varicosities
Interventions
endovenous ablation+polidocanol injectable microfoam 0.125%, Endovenous ablation+polidocanol injectable microfoam 1.0%, Endovenous ablation+polidocanol injectable foam 2.0%
Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
7
States / cities
Scottsdale, Arizona • Bradenton, Florida • Oak Brook, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Jul 21, 2026, 9:41 PM EDT
Withdrawn Phase 3 Interventional

Carvedilol vs Band Ligation vs Combination Therapy for Primary Prophylaxis of Variceal Bleeding

NCT02066649
View directory record Official record
Conditions
Portal Hypertension Related to Cirrhosis
Interventions
Carvedilol, Variceal band ligation
Drug · Procedure
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Jul 21, 2026, 9:41 PM EDT