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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Venous Insufficiency of Leg Clear all
Completed Not applicable Interventional Results available

Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)

NCT02395302
View directory record Official record
Conditions
Venous Leg Ulcer, Chronic Venous Insufficiency, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
Interventions
Dual Action Pneumatic Compression
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
6
States / cities
San Francisco, California • Miami, Florida • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2017 · Synced Sep 22, 2026, 6:49 AM EDT
Not listed Phase 1Phase 2 Interventional

Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis

NCT04833764
View directory record Official record
Conditions
Post-thrombotic Syndrome, Deep Vein Thrombosis Leg
Interventions
Rosuvastatin
Drug
Lead sponsor
Khanh Nguyen
Federal
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Sep 22, 2026, 6:49 AM EDT
Active, not recruiting Phase 2 Interventional

Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers

NCT03154619
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
0.1% TR 987, Placebo gel
Drug
Lead sponsor
SerenaGroup, Inc.
Network
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
9
States / cities
Los Angeles, California • North Miami Beach, Florida • Pembroke Pines, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers

NCT01549860
View directory record Official record
Conditions
Venous Insufficiency, Venous Reflux, Lower Extremity Ulcer
Interventions
MIST Therapy
Device
Lead sponsor
Celleration, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Weymouth, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 29, 2015 · Synced Sep 22, 2026, 6:49 AM EDT
Completed No phase listed Observational Results available

Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)

NCT03257254
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Varithena
Drug
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
76 participants
Timeline
2017 – 2020
U.S. locations
13
States / cities
Palo Alto, California • Sacramento, California • Darien, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)

NCT03075761
View directory record Official record
Conditions
Post Thrombotic Syndrome, Deep Vein Thrombosis
Interventions
Fitbit, 30-minute education session
Device · Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
7 Years to 21 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 17, 2021 · Synced Sep 22, 2026, 6:49 AM EDT
Terminated Not applicable Interventional Results available

The GORE Viabahn Endoprosthesis for the Treatment of Venous Occlusions and Stenoses

NCT01406795
View directory record Official record
Conditions
Venous Thrombosis
Interventions
Gore Viabahn Heparin Coated Stent
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Treatment Trial for Post-Thrombotic Syndrome

NCT00633971
View directory record Official record
Conditions
Post Thrombotic Syndrome
Interventions
complex lymphedema therapy
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Sep 22, 2026, 6:49 AM EDT
Not listed Not applicable Interventional

The Evaluation of OrCel for the Treatment of Venous Ulcers

NCT00270972
View directory record Official record
Conditions
Venous Insufficiency, Leg Ulcer
Interventions
Bilayered Cellular Matrix (OrCel)
Device
Lead sponsor
Ortec International
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
10
States / cities
Montgomery, Alabama • Phoenix, Arizona • Castro Valley, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2006 · Synced Sep 22, 2026, 6:49 AM EDT
Terminated Phase 4 Interventional Results available

Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations

NCT02929056
View directory record Official record
Conditions
Varicose Ulcer, Venous Insufficiency
Interventions
AmnioExCel dressing and compression therapy, SOC alginate dressing and compression therapy
Biological · Procedure
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 15, 2021 · Synced Sep 22, 2026, 6:49 AM EDT
Terminated Not applicable Interventional Results available

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

NCT03820947
View directory record Official record
Conditions
Venous Reflux
Interventions
VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
Device · Procedure
Lead sponsor
Medtronic Endovascular
Industry
Eligibility
18 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Prescott Valley, Arizona • Tucson, Arizona • Fresno, California + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort

NCT02015221
View directory record Official record
Conditions
Chronic Venous Insufficiency
Interventions
Dual Action Pneumatic Compression Device, Standard Compression Garments
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
11
States / cities
Phoenix, Arizona • Colton, California • La Jolla, California + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 14, 2016 · Synced Sep 22, 2026, 6:49 AM EDT
Completed No phase listed Observational

Evaluating the Occurence of New and Progression of Existing Peripheral Venous Disease in Leg Veins

NCT00508079
View directory record Official record
Conditions
Peripheral Vascular Diseases
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
Not listed
Enrollment
1,103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Sep 22, 2026, 6:49 AM EDT
Recruiting Not applicable Interventional

The ROle of Compression StocKings in Heart Failure Patients

NCT06350695
View directory record Official record
Conditions
Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
Interventions
low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema

NCT01079299
View directory record Official record
Conditions
Lymphedema
Interventions
Intermittent, gradient, pneumatic compression device
Device
Lead sponsor
Calvary Hospital, Bronx, NY
Other
Eligibility
21 Years to 95 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2012 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Phase 3 Interventional Results available

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2

NCT01737762
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP802-247, Vehicle
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
37
States / cities
Phoenix, Arizona • Carlsbad, California • Castro Valley, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Sep 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional

The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

NCT05489588
View directory record Official record
Conditions
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
Interventions
GORE® VIAFORT Vascular Stent
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
24
States / cities
Stanford, California • Darien, Connecticut • New Haven, Connecticut + 20 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 22, 2026, 6:49 AM EDT
Not listed Not applicable Interventional

Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections

NCT05633277
View directory record Official record
Conditions
Venous Reflux, Venous Insufficiency, Venous Ulcer, Venous Disease
Interventions
Polidocanol
Procedure
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional

Game-Based Foot & Ankle Exercise for Those With Lower Extremity Edema

NCT05520008
View directory record Official record
Conditions
Lower Extremity Swelling, Lower Extremity Edema, Venous Insufficiency of Leg
Interventions
Game-based exercise
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional

Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC

NCT06811909
View directory record Official record
Conditions
Non-infected Venous Leg Ulcer, Venous Leg Ulcer, Venous Insufficiency, Venous Stasis, Venous Reflux
Interventions
BR-AC, Standard Care
Other
Lead sponsor
BioStem Technologies
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
22
States / cities
Guntersville, Alabama • Castro Valley, California • Glendale, California + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional Results available

The GORE® VIABAHN® FORTEGRA Venous Stent IVC Study

NCT05409976
View directory record Official record
Conditions
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
Interventions
GORE® VIAFORT Vascular Stent
Device
Lead sponsor
W.L.Gore & Associates
Industry
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
8
States / cities
Stanford, California • Washington D.C., District of Columbia • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 22, 2026, 6:49 AM EDT
Not listed Phase 3 Interventional

Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers

NCT00232973
View directory record Official record
Conditions
Leg Ulcer
Interventions
ICXP007
Drug
Lead sponsor
Intercytex
Industry
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
31
States / cities
Montgomery, Alabama • Phoenix, Arizona • Tucson, Arizona + 26 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2008 · Synced Sep 22, 2026, 6:49 AM EDT
Completed Not applicable Interventional Results available

Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema

NCT04897035
View directory record Official record
Conditions
Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
Interventions
Dayspring Active Wearable Compression System
Device
Lead sponsor
Koya Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Los Altos, California • Morgan Hill, California
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 22, 2026, 6:49 AM EDT
Active, not recruiting Not applicable Interventional

Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the Periphery

NCT06642051
View directory record Official record
Conditions
Chronic Venous Insufficiency, CVI, Venous Malformations, Venous Leg Ulcers, Klippel-Trenaunay Syndrome, CLOVES Syndrome, Blue Rubber Bleb Nevus Syndrome
Interventions
High Intensity focused ultrasound
Device
Lead sponsor
Sonablate
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Darien, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 22, 2026, 6:49 AM EDT