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ClinicalTrials.gov public records Last synced Sep 17, 2026, 4:09 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Venous Leg Ulcers Clear all
Active, not recruiting Not applicable Interventional

Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the Periphery

NCT06642051
View directory record Official record
Conditions
Chronic Venous Insufficiency, CVI, Venous Malformations, Venous Leg Ulcers, Klippel-Trenaunay Syndrome, CLOVES Syndrome, Blue Rubber Bleb Nevus Syndrome
Interventions
High Intensity focused ultrasound
Device
Lead sponsor
Sonablate
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Darien, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 17, 2026, 4:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers

NCT02838784
View directory record Official record
Conditions
Venous Ulcer, Foot Ulcer, Diabetic
Interventions
Artacent Human Amniotic Membrane, Standard of Care
Other · Procedure
Lead sponsor
Tides Medical
Industry
Eligibility
18 Years and older
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
7
States / cities
Arcadia, California • New Iberia, Louisiana • New Orleans, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2017 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional

Study Assessing Complete Wound Healing by Comparing Surgenex® PelloGraft in Treating DFU and SanoGraft® in Treating VLU to SOC

NCT06515093
View directory record Official record
Conditions
Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
PelloGraft, SanoGraft
Other
Lead sponsor
Surgenex
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Vista, California • Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 17, 2026, 4:09 AM EDT
Terminated Not applicable Interventional Results available

VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

NCT03820947
View directory record Official record
Conditions
Venous Reflux
Interventions
VenaSeal™ System, Endothermal Ablation (ETA), Surgical Stripping
Device · Procedure
Lead sponsor
Medtronic Endovascular
Industry
Eligibility
18 Years and older
Enrollment
506 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
12
States / cities
Prescott Valley, Arizona • Tucson, Arizona • Fresno, California + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of the OsciPulse Rapid Cycling Compression Device Effects on Venous Blood Flow

NCT05087108
View directory record Official record
Conditions
Venous Thromboses, Venous Stasis
Interventions
OsciPulse system, Reference Therapy 1, Refence Therapy 2
Device
Lead sponsor
OsciFlex LLC
Industry
Eligibility
40 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 17, 2026, 4:09 AM EDT
Suspended Not applicable Interventional

Effect of Hyaluronic Acid ECM on Venous Ulcers

NCT02930499
View directory record Official record
Conditions
Venous Ulcers
Interventions
Hyalomatrix extra-cellular matrix, Mepilex wound dressing
Device
Lead sponsor
Calvary Hospital, Bronx, NY
Other
Eligibility
21 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Sep 17, 2026, 4:09 AM EDT
Not yet recruiting Phase 1 Interventional

LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults

NCT07463365
View directory record Official record
Conditions
Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds, VLU
Interventions
LUT017 gel
Drug
Lead sponsor
Antoni Ribas
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Phase 4 Interventional

A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers

NCT00235209
View directory record Official record
Conditions
Leg Ulcer
Interventions
Collagen ORC Antimicrobial Matrix (CAM)
Device
Lead sponsor
Ethicon, Inc.
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Timeline
2004 – 2005
U.S. locations
3
States / cities
Fort Lauderdale, Florida • South Miami, Florida • Warren, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2011 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional

A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

NCT05588583
View directory record Official record
Conditions
Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
Interventions
Mepilex Up
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Castro Valley, California • Los Angeles, California • Miami, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Phase 2 Interventional

Adipose Derived Regenerative Cellular Therapy of Chronic Wounds

NCT02092870
View directory record Official record
Conditions
Diabetic Foot, Venous Ulcer, Pressure Ulcer
Interventions
Adipose derived stem cells
Drug
Lead sponsor
Tower Outpatient Surgical Center
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Sep 17, 2026, 4:09 AM EDT
Enrolling by invitation No phase listed Observational

Kerecis Real-World Fish Skin Graft Registry

NCT06384183
View directory record Official record
Conditions
Wounds, Pressure Ulcer, Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound, Soft Tissue Reinforcement
Interventions
Kerecis Fish Skin Graft
Device
Lead sponsor
Kerecis Ltd.
Industry
Eligibility
Not listed
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Sarasota, Florida • Greensboro, North Carolina • Beavercreek, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2024 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Implications of Genetic Variations of Venous Stasis Ulceration

NCT02034396
View directory record Official record
Conditions
Venous Ulcers
Interventions
Blood Draw
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
377 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2022 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting No phase listed Observational

Evaluating the Durability of Closure for Venous Leg Ulcers

NCT06697925
View directory record Official record
Conditions
Venous Leg, Venous Leg Ulcer (VLU), Venous Leg Ulcer, Venous Ulcer, VLU
Interventions
Not listed
Lead sponsor
Kerecis Ltd.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Monroeville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional

A Clinical Investigation to Follow the Progress of Exuding Chronic Venous Leg Ulcers Using a Non-Bordered Foam Dressing

NCT05608317
View directory record Official record
Conditions
Wounds, Wound of Skin, Wound Leg, Venous Leg Ulcer
Interventions
ALLEVYN Non-Adhesive
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
San Francisco, California • Miami, Florida • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2024 · Synced Sep 17, 2026, 4:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Non-Invasive Management of Chronic Venous Insufficiency

NCT00950378
View directory record Official record
Conditions
Venous Insufficiency
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 28, 2013 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Not applicable Interventional

Use of dHACM in the Treatment of Venous Leg Ulcers

NCT02011503
View directory record Official record
Conditions
Leg Ulcer
Interventions
Multi-layer compression therapy, Application of dHACM
Procedure · Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
15
States / cities
Phoenix, Arizona • Carlsbad, California • Castro Valley, California + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2018 · Synced Sep 17, 2026, 4:09 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Natrox Oxygen Wound Therapy on Non-healing Wounds and Implication of Remote Monitoring and Telehealth for Management in the Home.

NCT04746573
View directory record Official record
Conditions
Non-healing Wounds
Interventions
Natrox Topical Oxygen Therapy
Device
Lead sponsor
Inotec AMD Limited
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 17, 2026, 4:09 AM EDT
Completed No phase listed Observational Results available

Safety Follow-Up to HP 802-247-09-015

NCT00900029
View directory record Official record
Conditions
Venous Leg Ulcer, Venous Stasis Ulcer
Interventions
No HP802 Treatment, No HP802 Vehicle Treatment
Biological · Other
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
29
States / cities
Tucson, Arizona • Castro Valley, California • Encinitas, California + 26 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Sep 17, 2026, 4:09 AM EDT
Completed Phase 1 Interventional

Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers

NCT02652572
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Granexin
Drug
Lead sponsor
Xequel Bio, Inc.
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
3
States / cities
Augusta, Georgia • Spartanburg, South Carolina • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Sep 17, 2026, 4:09 AM EDT
Terminated Phase 2 Interventional Results available

A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers

NCT02154087
View directory record Official record
Conditions
Venous Leg Ulcers
Interventions
HP802-247
Biological
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2016 · Synced Sep 17, 2026, 4:09 AM EDT
Terminated Not applicable Interventional

Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds

NCT02071979
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
Interventions
Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections, Standard Wound Care
Device · Procedure
Lead sponsor
Arteriocyte, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
6
States / cities
Bakersfield, California • Idaho Falls, Idaho • Englewood, New Jersey + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 17, 2026, 4:09 AM EDT
Terminated Phase 2 Interventional Results available

Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers

NCT00545298
View directory record Official record
Conditions
Venous Ulcers
Interventions
Nitric Oxide - same dose 6 wks, Nitric Oxide modified treatment
Drug
Lead sponsor
Nitric BioTherapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2012 · Synced Sep 17, 2026, 4:09 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy

NCT03716167
View directory record Official record
Conditions
Venous Leg Ulcer
Interventions
Summus Laser, Summus Laser Sham
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 17, 2026, 4:09 AM EDT