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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Ventilation Therapy; Complications Clear all
Completed Phase 2Phase 3 Interventional

Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome

NCT01203358
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia
Interventions
Exosurf, Survanta
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Hours
Enrollment
617 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1991 – 1992
U.S. locations
13
States / cities
Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Jul 22, 2026, 3:36 AM EDT
No Longer Available No phase listed Expanded access

Aerosolized Infasurf Treatment Protocol: Aerosolized Infasurf for Spontaneously Breathing Patients With Early RDS (AERO-03)

NCT03582930
View directory record Official record
Conditions
Neonatal Respiratory Distress
Interventions
Infasurf Aero
Combination Product
Lead sponsor
ONY
Industry
Eligibility
Up to 42 Weeks
U.S. locations
5
States / cities
Jackson, Mississippi • Buffalo, New York • Greenville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Phase 2 Interventional

Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury

NCT00448045
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Manual and mechanical assisted cough, Incentive spirometry
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 14, 2013 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit

NCT00282594
View directory record Official record
Conditions
Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions
Novolin R (human recombinant Insulin)
Drug
Lead sponsor
Genesys
Other
Eligibility
18 Years and older
Enrollment
317 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 26, 2006 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional

Cognitive Behavioral Therapy for Mechanical Ventilation Wean

NCT04763590
View directory record Official record
Conditions
Anxiety, Cognitive Behavioral Therapy, Mechanical Ventilation Complication
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
Up to 100 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Jul 22, 2026, 3:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

NCT07464860
View directory record Official record
Conditions
Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological, Breathing Techniques, Breathing Exercises, Hypothalamic Pituitary Adrenal, Relaxation, Relaxation Therapy, Cortisol, Postoperative Pain, Postoperative Anxiety, Postoperative Depression, Quality of Recovery (QoR-15)
Interventions
A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
65 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional

Manually Operated Communication System

NCT03630003
View directory record Official record
Conditions
Communication, Ventilation Therapy; Complications
Interventions
MOCS, Post-use interview
Device · Other
Lead sponsor
J. Matthias Walz
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Jul 22, 2026, 3:36 AM EDT
Recruiting Phase 3 Interventional

InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS

NCT05960929
View directory record Official record
Conditions
Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
Interventions
Infasurf Aero™
Combination Product
Lead sponsor
ONY
Industry
Eligibility
29 Weeks to 36 Weeks
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
10
States / cities
Phoenix, Arizona • San Diego, California • Jacksonville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Jul 22, 2026, 3:36 AM EDT
Completed No phase listed Observational

Comparison of Dialysis Therapies on Cognitive Function

NCT00597103
View directory record Official record
Conditions
End Stage Renal Disease, Chronic Kidney Disease
Interventions
Cognitive Function Testing-10 Tests, Sleep Assessment Testing, Periodic Leg Movement Syndrome Assessment
Other
Lead sponsor
Satellite Healthcare
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
Mountain View, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional

Intraoperative Protective Ventilation and Postoperative Pulmonary Complications

NCT02671721
View directory record Official record
Conditions
Complication of Ventilation Therapy, Postoperative Respiratory Complications
Interventions
Maximal Compliance, Transpulmonary Pressure
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2019 · Synced Jul 22, 2026, 3:36 AM EDT
Terminated Phase 3 Interventional

Inhaled Nitric Oxide Study for Respiratory Failure in Newborns

NCT00005776
View directory record Official record
Conditions
Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration, Respiratory Distress Syndrome, Newborn, Respiratory Insufficiency
Interventions
Inhaled nitric oxide, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 14 Days
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 1998
U.S. locations
11
States / cities
Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Jul 22, 2026, 3:36 AM EDT
Terminated No phase listed Observational

Observational Study of Blood Pressure Measurements and Continuous Dialysis

NCT01286506
View directory record Official record
Conditions
Kidney Failure, Respiratory Failure, Critical Illness, Shock
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 30, 2016 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional Results available

Comparison of Effectiveness of Mask Ventilation and Endotracheal Tube in Pharynx (TTIP) in Patients With Potential Difficult Airway

NCT05005390
View directory record Official record
Conditions
Ventilation Therapy; Complications
Interventions
TTIP ventilation, Mask Ventilation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 23, 2024 · Synced Jul 22, 2026, 3:36 AM EDT
Terminated Phase 3 Interventional Results available

Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome

NCT00004500
View directory record Official record
Conditions
Meconium Aspiration
Interventions
Lucinactant, Standard Care
Drug · Other
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
Up to 48 Hours
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
1
States / cities
Warrington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 2, 2012 · Synced Jul 22, 2026, 3:36 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Little Lungs Study

NCT06855043
View directory record Official record
Conditions
Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome
Interventions
Calfactant, Budesonide
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
7 Days to 14 Days
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional

Testing a Novel Manual Communication System for Mechanically Ventilated ICU Patients

NCT04105751
View directory record Official record
Conditions
Communication, Ventilation Therapy; Complications
Interventions
Novel Communication System
Device
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Jul 22, 2026, 3:36 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Prophylactic Minimally Invasive Surfactant Evaluation

NCT06007547
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Premature Birth
Interventions
Poractant Alfa
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
Up to 15 Minutes
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jul 22, 2026, 3:36 AM EDT
Withdrawn Not applicable Interventional

Effectiveness of Jamboxx Respiratory Therapy Device: Study 1

NCT03533400
View directory record Official record
Conditions
Spinal Cord Injuries, Respiratory Complication
Interventions
Jamboxx Respiratory Therapy Device, Jamboxx Musical Device
Device
Lead sponsor
My Music Machines Inc.
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Jul 22, 2026, 3:36 AM EDT
Terminated Phase 2 Interventional Results available

SURFAXIN® Treatment for Prevention of Bronchopulmonary Dysplasia (BPD) in Very Low Birth Weight (VLBW) Infants.

NCT00215540
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Premature Birth, Bronchopulmonary Dysplasia
Interventions
Lucinactant 175 mg/kg, Lucinactant 90 mg/kg, Placebo
Drug
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
3 Days to 10 Days
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Warrington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Jul 22, 2026, 3:36 AM EDT
Completed No phase listed Observational

Post-extubation Assessment of Laryngeal Symptoms and Severity

NCT03726086
View directory record Official record
Conditions
Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
Interventions
laryngoscopy
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Jul 22, 2026, 3:36 AM EDT
Completed No phase listed Observational

Ketamine Infusion as Sedative Analgesic in Severe ARDS

NCT04818827
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions
Not listed
Lead sponsor
Interfaith Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 22, 2026, 3:36 AM EDT
Completed No phase listed Observational

Parental Perception of COVID-19 Vaccine in Technology Dependent Patients

NCT05084976
View directory record Official record
Conditions
Chronic Respiratory Failure, Tracheostomy Complication, Mechanical Ventilation Complication
Interventions
COVID 19 vaccine counseling
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
Up to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Jul 22, 2026, 3:36 AM EDT
Completed Not applicable Interventional Results available

Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function

NCT04295564
View directory record Official record
Conditions
Neonatal, Premature Birth, Respiratory Distress Syndrome
Interventions
Additional 2 weeks of CPAP
Other
Lead sponsor
Cynthia McEvoy
Other
Eligibility
1 Day to 12 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 22, 2026, 3:36 AM EDT
Not yet recruiting Phase 2 Interventional

Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy

NCT07212595
View directory record Official record
Conditions
Acute Kidney Injury, Mechanical Ventilation
Interventions
Amino Acid infusion, Lactated ringers solution
Drug
Lead sponsor
Dana Fuhrman
Other
Eligibility
Up to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 3:36 AM EDT