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Conditions: Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
Interventions: Infasurf Aero™; Combination Product
Lead sponsor: ONY; Industry
Eligibility: 29 Weeks to 36 Weeks
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 10
States / cities: Phoenix, Arizona • San Diego, California • Jacksonville, Florida + 6 more

Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia
Interventions: Dexamethasone Early, Dexamethasone Late; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: 13 Days to 15 Days
Enrollment: 371 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1992 – 1994
U.S. locations: 13
States / cities: Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 10 more

Conditions: Complication of Ventilation Therapy
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological, Breathing Techniques, Breathing Exercises, Hypothalamic Pituitary Adrenal, Relaxation, Relaxation Therapy, Cortisol, Postoperative Pain, Postoperative Anxiety, Postoperative Depression, Quality of Recovery (QoR-15)
Interventions: A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video; Behavioral
Lead sponsor: University of Arizona; Other
Eligibility: 65 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration, Respiratory Distress Syndrome, Newborn, Respiratory Insufficiency
Interventions: Inhaled Nitric Oxide, Standard iNO therapy; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 14 Days
Enrollment: 302 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2003
U.S. locations: 18
States / cities: Birmingham, Alabama • Phoenix, Arizona • Palo Alto, California + 14 more

Conditions: Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
Interventions: Ventilator protocol; Other
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 1 Month to 18 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 6
States / cities: Chicago, Illinois • Indianapolis, Indiana • Hershey, Pennsylvania + 3 more

Conditions: Airway Complication of Anesthesia, Ventilation Therapy; Complications, Hypoxia, Hypoventilation
Interventions: A/Z Supraglottic airway; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Obstructive Sleep Apnea
Interventions: CPAP, Pre-natal care; Device · Other
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years and older · Female only
Enrollment: 193 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: San Diego, California

Conditions: Communication, Ventilation Therapy; Complications
Interventions: Novel Communication System; Device
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Postoperative Atelectasis, Postoperative Hypoxemia, Postoperative Pneumonia, Postoperative Pulmonary Complications, Patient Adherence, Incentive Spirometry, Respiratory Therapy, Respiratory Insufficiency
Interventions: Alarms; Device
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 100 Years
Enrollment: 231 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Kidney Failure, Respiratory Failure, Critical Illness, Shock
Interventions: Not listed
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Complication of Ventilation Therapy, Postoperative Respiratory Complications
Interventions: Maximal Compliance, Transpulmonary Pressure; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 100 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration, Respiratory Distress Syndrome, Newborn, Respiratory Insufficiency
Interventions: Inhaled nitric oxide, Placebo; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 14 Days
Enrollment: 235 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1995 – 1998
U.S. locations: 11
States / cities: Palo Alto, California • New Haven, Connecticut • Washington D.C., District of Columbia + 8 more

Conditions: Anxiety, Cognitive Behavioral Therapy, Mechanical Ventilation Complication
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: Up to 100 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Ventilation Therapy; Complications
Interventions: TTIP ventilation, Mask Ventilation; Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 147 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Postoperative Cognitive Dysfunction, Postoperative Delirium, Obstructive Sleep Apnea
Interventions: Goal directed therapy (GDT); Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 45 Years to 75 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome
Interventions: Calfactant, Budesonide; Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 7 Days to 14 Days
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Madison, Wisconsin

Conditions: Meconium Aspiration
Interventions: Lucinactant, Standard Care; Drug · Other
Lead sponsor: Windtree Therapeutics; Industry
Eligibility: Up to 48 Hours
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2004
U.S. locations: 1
States / cities: Warrington, Pennsylvania

Conditions: Spinal Cord Injuries, Respiratory Complication
Interventions: Jamboxx Respiratory Therapy Device, Jamboxx Musical Device; Device
Lead sponsor: My Music Machines Inc.; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Albany, New York

Conditions: Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
Interventions: laryngoscopy; Diagnostic Test
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 365 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Obstructive Sleep Apnea, Delayed Emergence From Anesthesia
Interventions: Modafinil, Placebo; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Communication, Ventilation Therapy; Complications
Interventions: MOCS, Post-use interview; Device · Other
Lead sponsor: J. Matthias Walz; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Boston, Massachusetts • Worcester, Massachusetts

Conditions: Spinal Cord Injury
Interventions: Manual and mechanical assisted cough, Incentive spirometry; Behavioral
Lead sponsor: Kessler Foundation; Other
Eligibility: 18 Years to 70 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions: Novolin R (human recombinant Insulin); Drug
Lead sponsor: Genesys; Other
Eligibility: 18 Years and older
Enrollment: 317 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Grand Blanc, Michigan

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InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS

Dexamethasone Therapy in VLBW Infants at Risk of CLD

Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery

Feasibility of Breathwork Intervention With Older Adults After Knee Surgery

Early Inhaled Nitric Oxide for Respiratory Failure in Newborns

Clinical Decision Support Tool in PARDS Pilot Study

Structural Modification In Supraglottic Airway Device

Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy

Testing a Novel Manual Communication System for Mechanically Ventilated ICU Patients

REMINDers for Incentive Spirometry in PACU (REMIND-IS in PACU)

Observational Study of Blood Pressure Measurements and Continuous Dialysis

Intraoperative Protective Ventilation and Postoperative Pulmonary Complications

Inhaled Nitric Oxide Study for Respiratory Failure in Newborns

Cognitive Behavioral Therapy for Mechanical Ventilation Wean

Comparison of Effectiveness of Mask Ventilation and Endotracheal Tube in Pharynx (TTIP) in Patients With Potential Difficult Airway

Taking Brain Monitoring to the Next Level

Little Lungs Study

Phase III Randomized Study of Lucinactant in Full Term Newborn Infants With Meconium Aspiration Syndrome

Effectiveness of Jamboxx Respiratory Therapy Device: Study 1

Post-extubation Assessment of Laryngeal Symptoms and Severity

Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea

Manually Operated Communication System

Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit