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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:09 AM EDT

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Showing 1–24 of 75 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Weaning Clear all
Terminated Not applicable Interventional

Esophageal Balloon Guided Weaning of the Morbidly Obese Patient

NCT02323009
View directory record Official record
Conditions
Morbid Obesity
Interventions
Esophageal Balloon, Cstat
Device · Other
Lead sponsor
East Carolina University
Other
Eligibility
19 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 21, 2026, 9:09 AM EDT
Completed No phase listed Observational

CentriMag Failure-to-Wean Post Approval Study

NCT04464785
View directory record Official record
Conditions
Heart Failure
Interventions
CentriMag Circulatory Support System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
8
States / cities
Little Rock, Arkansas • Atlanta, Georgia • Oak Lawn, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Oct 21, 2026, 9:09 AM EDT
Withdrawn No phase listed Observational

Electrocardiographic Autonomic Function Measures in Mechanically Ventilated Patients

NCT00844935
View directory record Official record
Conditions
Disorders of the Autonomic Nervous System, Cardiovascular Abnormalities, Respiratory Disorders
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 28, 2012 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Phase 1 Interventional

Inspiratory Muscle Training in Ventilator Dependent Patients

NCT00419458
View directory record Official record
Conditions
Failure to Wean, Respiratory Failure, Ventilator Dependent
Interventions
inspiratory muscle strength training
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
16 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 9, 2009 · Synced Oct 21, 2026, 9:09 AM EDT
Recruiting Not applicable Interventional

Optimal Timing for Spontaneous Breathing Trials

NCT06561295
View directory record Official record
Conditions
Respiration, Artificial, Weaning
Interventions
Later Morning Timing of Spontaneous Breathing Trials
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years and older
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Phase 1 Interventional

Music Therapy for Patients Being Weaned From Mechanical Ventilation

NCT00178139
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Music Therapy
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2015 · Synced Oct 21, 2026, 9:09 AM EDT
Terminated Not applicable Interventional

Weaning From Mechanical Ventilation Using Permissive Hypercarbia

NCT00357929
View directory record Official record
Conditions
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Interventions
Permissive hypercarbia
Procedure
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 21, 2026, 9:09 AM EDT
Terminated Not applicable Interventional

A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation

NCT03783884
View directory record Official record
Conditions
Ventilator Induced Diaphragm Dysfunction
Interventions
Lungpacer Diaphragm Pacing Therapy
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
22
States / cities
Stanford, California • Aurora, Colorado • Gainesville, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Oct 21, 2026, 9:09 AM EDT
Enrolling by invitation Not applicable Interventional

Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning

NCT07710469
View directory record Official record
Conditions
Ventilated Patient in Intensive Care
Interventions
Weighted blanket, Standard hospital linens
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 21, 2026, 9:09 AM EDT
Enrolling by invitation No phase listed Observational

CHAMP For the Feeder: Tube Feeding Study

NCT06052891
View directory record Official record
Conditions
Feeding Disorders
Interventions
CHAMP Application
Device
Lead sponsor
Lori Erickson
Other
Eligibility
1 Month to 6 Years
Enrollment
245 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 21, 2026, 9:09 AM EDT
Recruiting Phase 2 Interventional

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

NCT06319248
View directory record Official record
Conditions
Sepsis, Low Blood Pressure
Interventions
Midodrine, Standard of Care
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
5
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Mankato, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 21, 2026, 9:09 AM EDT
Not listed No phase listed Observational

Electrical Activity of the Diaphragm During Extubation Readiness Testing

NCT00814853
View directory record Official record
Conditions
Extubation
Interventions
NAVA (Extubation readiness testing failures)
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 18 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 4, 2009 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Not applicable Interventional

Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing (RESCUE1)

NCT03107949
View directory record Official record
Conditions
Ventilator Induced Diaphragm Dysfunction
Interventions
Lungpacer DPTS (Diaphragm Pacing Therapy System)
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
4
States / cities
Gainesville, Florida • New York, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 10, 2021 · Synced Oct 21, 2026, 9:09 AM EDT
Completed No phase listed Observational

Weaning From Mechanical Ventilation in the ICU

NCT01817608
View directory record Official record
Conditions
Quality of Life
Interventions
Not listed
Lead sponsor
Amal Jubran
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 25, 2013 · Synced Oct 21, 2026, 9:09 AM EDT
Terminated Not applicable Interventional

Auricular Acupuncture to Facilitate Outpatient Opioid Weaning

NCT02882048
View directory record Official record
Conditions
Narcotic Addiction
Interventions
NADA Protocol, Medication management
Procedure · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Oct 21, 2026, 9:09 AM EDT
Withdrawn Phase 4 Interventional

Automated Ventilator Controlled Weaning vs Daily Spontaneous Breathing Trial in Difficult to Wean ICU Patients

NCT00813839
View directory record Official record
Conditions
Mechanical Ventilation, Weaning
Interventions
daily weaning trails
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 8, 2015 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Phase 4 Interventional Results available

Embrace TDD: Post-Market Study to Evaluate Intrathecal Morphine as an Alternative to Systemic Opioids for Chronic Pain

NCT03761277
View directory record Official record
Conditions
Chronic Non-malignant Pain, Chronic Pain, Pain, Back, Pain, Leg
Interventions
Medtronic SynchroMed™ II infusion system, Preservative-free morphine sulfate (PFMS)
Device · Drug
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
16
States / cities
Anchorage, Alaska • Carlsbad, California • Napa, California + 13 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 21, 2026, 9:09 AM EDT
Terminated No phase listed Observational

Prediction of Weaning Outcomes by Using Rate of Change of Rapid Shallow Breathing Index

NCT00366197
View directory record Official record
Conditions
Rapid Shallow Breathing
Interventions
Not listed
Lead sponsor
Atlantic Health System
Other
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 16, 2014 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Not applicable Interventional

Trial of Weaning of Nasal Continuous Positive Airway Pressure (CPAP)

NCT01215591
View directory record Official record
Conditions
Preterm Neonates
Interventions
Gradual weaning from Nasal CPAP in preterm neonates
Procedure
Lead sponsor
Maimonides Medical Center
Other
Eligibility
24 Weeks to 32 Weeks
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Not applicable Interventional

Feeding Young Children Study: Bottle Weaning Intervention

NCT00756626
View directory record Official record
Conditions
Childhood Obesity
Interventions
Bottle Weaning Intervention
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
12 Months to 13 Months
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2018 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Not applicable Interventional Results available

Comparison Between Two Methods of Spontaneous Breathing Trial (SBT)

NCT00400881
View directory record Official record
Conditions
Respiratory Failure
Interventions
automatic tube compensation
Other
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2017 · Synced Oct 21, 2026, 9:09 AM EDT
Terminated No phase listed Interventional Results available

Breath Synchronized Abdominal Muscle Stimulation to Facilitate Ventilator Weaning: a Pilot Study

NCT03019107
View directory record Official record
Conditions
Electric Stimulation, Respiration, Artificial, Ventilator Weaning
Interventions
Breath synchronized abdominal NMES, Sham breath synchronized abdominal NMES
Device
Lead sponsor
Liberate Medical
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 8, 2021 · Synced Oct 21, 2026, 9:09 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children

NCT03815019
View directory record Official record
Conditions
Feeding Behavior, Feeding Disorder of Infancy or Early Childhood
Interventions
Megestrol Acetate, iKanEat Behavioral Intervention
Drug · Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
9 Months to 108 Months
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
8
States / cities
San Diego, California • Orlando, Florida • Indianapolis, Indiana + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 21, 2026, 9:09 AM EDT
Enrolling by invitation Not applicable Interventional

Parent Tube Weaning Interviews

NCT07054983
View directory record Official record
Conditions
Feeding Difficulties, Remote Patient Monitoring, Pediatric Feeding Disorders
Interventions
Qualitative Research Interview
Other
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 21, 2026, 9:09 AM EDT