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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Weaning Failure Clear all
Completed No phase listed Observational

CentriMag Failure-to-Wean Post Approval Study

NCT04464785
View directory record Official record
Conditions
Heart Failure
Interventions
CentriMag Circulatory Support System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
8
States / cities
Little Rock, Arkansas • Atlanta, Georgia • Oak Lawn, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Jul 22, 2026, 6:54 AM EDT
Completed No phase listed Observational

Preventing Failed Extubations

NCT06301867
View directory record Official record
Conditions
Mechanical Ventilation Complication, Weaning Failure
Interventions
Plateau Pressure
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years to 120 Years
Enrollment
248 participants
Timeline
2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Jul 22, 2026, 6:54 AM EDT
Terminated Not applicable Interventional

A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation

NCT03783884
View directory record Official record
Conditions
Ventilator Induced Diaphragm Dysfunction
Interventions
Lungpacer Diaphragm Pacing Therapy
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
22
States / cities
Stanford, California • Aurora, Colorado • Gainesville, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Not applicable Interventional Results available

Pilot Study on Pairing Sedation Strategies and Weaning

NCT02219659
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
Drug
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jul 22, 2026, 6:54 AM EDT
Terminated Not applicable Interventional

Randomized Study of the pdSTIM™ System in Failure to Wean Mechanically Ventilated Patients

NCT05998018
View directory record Official record
Conditions
Neuromodulation, Phrenic Nerve Stimulation, Ventilator Induced Diaphragm Dysfunction, Mechanical Ventilation Weaning
Interventions
pdSTIM System Therapy, Conventional Medical Management
Device · Other
Lead sponsor
Stimdia Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
21
States / cities
Mobile, Alabama • Chandler, Arizona • Goodyear, Arizona + 18 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Phase 1Phase 2 Interventional

Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support

NCT01108575
View directory record Official record
Conditions
Respiratory Failure
Interventions
IMST, Sham IMST
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 10, 2013 · Synced Jul 22, 2026, 6:54 AM EDT
Withdrawn No phase listed Observational

Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population

NCT01795196
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Jul 22, 2026, 6:54 AM EDT
Completed No phase listed Observational Results available

Third International Study on Mechanical Ventilation

NCT01093482
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Not listed
Lead sponsor
Hospital Universitario Getafe
Other
Eligibility
18 Years and older
Enrollment
8,151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
18
States / cities
Iowa City, Iowa • Louisville, Kentucky • Boston, Massachusetts + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Jul 22, 2026, 6:54 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

VentFree: A Novel Abdominal Stimulator to Assist With Ventilator Weaning

NCT02224352
View directory record Official record
Conditions
COPD, Weaning Failure
Interventions
Functional neuromuscular electrical stimulation
Device
Lead sponsor
Edward Hines Jr. VA Hospital
Federal
Eligibility
18 Years to 90 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2022
U.S. locations
2
States / cities
Hines, Illinois • Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Not applicable Interventional

Weaning From Prolonged Mechanical Ventilation

NCT01541462
View directory record Official record
Conditions
Acute Mechanical Ventilatory Failure
Interventions
Weaning
Other
Lead sponsor
RML Specialty Hospital
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2011
U.S. locations
1
States / cities
Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 29, 2012 · Synced Jul 22, 2026, 6:54 AM EDT
Terminated Not applicable Interventional Results available

Caffeine to Reduce Mechanical Ventilation in Preterm Infants

NCT01751724
View directory record Official record
Conditions
Prematurity, Apnea, Respiratory Failure
Interventions
Caffeine citrate, Normal saline
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
1 Day to 5 Days
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Not applicable Interventional Results available

Comparison Between Two Methods of Spontaneous Breathing Trial (SBT)

NCT00400881
View directory record Official record
Conditions
Respiratory Failure
Interventions
automatic tube compensation
Other
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Phase 1 Interventional

Inspiratory Muscle Training in Ventilator Dependent Patients

NCT00419458
View directory record Official record
Conditions
Failure to Wean, Respiratory Failure, Ventilator Dependent
Interventions
inspiratory muscle strength training
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
16 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 8, 2009 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Not applicable Interventional Results available

CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass

NCT00819793
View directory record Official record
Conditions
Heart Failure
Interventions
CentriMag Ventricular Assist System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
14
States / cities
Phoenix, Arizona • New Haven, Connecticut • Lexington, Kentucky + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2022 · Synced Jul 22, 2026, 6:54 AM EDT
Not yet recruiting Not applicable Interventional

Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients

NCT07452406
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Interventions
Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 22, 2026, 6:54 AM EDT
Terminated Not applicable Interventional

Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity

NCT05530434
View directory record Official record
Conditions
Respiratory Failure, Obesity
Interventions
transpulmonary pressure guided positive end expiratory pressure, standard positive end expiratory pressure
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 22, 2026, 6:54 AM EDT
Recruiting Not applicable Interventional

Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants

NCT06123143
View directory record Official record
Conditions
Neonatal Respiratory Failure
Interventions
Standardized/structured CPAP weaning protocol
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
Up to 30 Weeks
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
Escondido, California • La Jolla, California • Murrieta, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Jul 22, 2026, 6:54 AM EDT
Completed No phase listed Observational

Variability Analysis as a Predictor of Liberation From Mechanical Ventilation

NCT01140750
View directory record Official record
Conditions
Mechanical Ventilation, Autonomic Nervous System Diseases
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 8, 2010 · Synced Jul 22, 2026, 6:54 AM EDT
Completed Not applicable Interventional

Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing (RESCUE1)

NCT03107949
View directory record Official record
Conditions
Ventilator Induced Diaphragm Dysfunction
Interventions
Lungpacer DPTS (Diaphragm Pacing Therapy System)
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
4
States / cities
Gainesville, Florida • New York, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 9, 2021 · Synced Jul 22, 2026, 6:54 AM EDT