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Showing 1–24 of 276 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Wrinkles Clear all
Not listed No phase listed Observational Accepts healthy volunteers

A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines

NCT02626598
View directory record Official record
Conditions
Rhytidosis Facialis
Interventions
Blended Belotero
Device
Lead sponsor
Skin Care and Laser Physicians of Beverly Hills
Other
Eligibility
25 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2015 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

TriActive+ Radiofrequency (RF) for Non-Invasive Treatment of Wrinkles and Rhytides

NCT01859611
View directory record Official record
Conditions
Wrinkles, Rhytides
Interventions
TriActive+ RF
Device
Lead sponsor
El. En. SpA
Industry
Eligibility
30 Years to 60 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Indianapolis, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Evaluation of the PlasmaJet Neutral Argon Plasma System to Treat Skin Ageing

NCT00761878
View directory record Official record
Conditions
Skin Aging
Interventions
Exposure to plasma energy
Procedure
Lead sponsor
Plasma Surgical Inc
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Fayetteville, New York
Source: ClinicalTrials.gov public record
Updated Jul 6, 2009 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Poly-L-lactic Acid for Skin Quality

NCT02003833
View directory record Official record
Conditions
Skin Aging
Interventions
Poly-L-lactic acid, Placebo comparator
Device
Lead sponsor
Sadick Research Group
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Carmel, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2015 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Identify if Chemist Confessions Retinol Cream Works to Improve the Appearance of Early Signs of Aging.

NCT05039476
View directory record Official record
Conditions
Wrinkle, Aging
Interventions
Retinol face cream, Placebo face cream
Dietary Supplement
Lead sponsor
Chemist Confessions, Inc.
Industry
Eligibility
30 Years to 50 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 5, 2026, 4:17 PM EDT
Active, not recruiting Not applicable Interventional

A Study to Determine if RADIESSE® Dilute Treatment in Décolleté of Adult Women Affects Radiographic Imaging Assessments

NCT07086248
View directory record Official record
Conditions
Décolleté Wrinkles
Interventions
Radiesse
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
40 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Alpharetta, Georgia
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fractional Radiofrequency for Treatment of Acne Scars and Wrinkles

NCT05827510
View directory record Official record
Conditions
Acne, Wrinkle
Interventions
BTL-585F
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
2
States / cities
Davie, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 5, 2026, 4:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy and Safety of the triLift™ System

NCT05773924
View directory record Official record
Conditions
Skin Laxity, Wrinkle
Interventions
triLift system
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
35 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health

NCT03769779
View directory record Official record
Conditions
Aging, Wrinkle, Skin Elasticity, Healthy, Hydration
Interventions
FloraGLO Lutein, Safflower Oil
Dietary Supplement
Lead sponsor
Kemin Foods LC
Industry
Eligibility
30 Years to 65 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Port Chester, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 5, 2026, 4:17 PM EDT
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

Assess Impact of Microdroplet Hyaluronic Acid Filler on Skin Quality in Patients on Glucagon-like Peptide-1 Agonists

NCT07221461
View directory record Official record
Conditions
Wrinkle
Interventions
Skinvive
Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
25 Years to 50 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color

NCT01012388
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • Chevy Chase, Maryland • Ypsilanti, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Sep 5, 2026, 4:17 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

A Study Assessing KB304 for the Treatment of Wrinkles in Women

NCT06724900
View directory record Official record
Conditions
Wrinkles in Decolletage, Pigmentation, Décolleté Wrinkles
Interventions
KB304, 0.9% Normal Saline (NS)
Biological · Drug
Lead sponsor
Krystal Biotech, Inc.
Industry
Eligibility
18 Years to 75 Years · Female only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 5, 2026, 4:17 PM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines

NCT07421544
View directory record Official record
Conditions
Fine Lines, Wrinkle, Facial Laxity, Volume Loss
Interventions
Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid
Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 5, 2026, 4:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Epidermal Delivery of Ani-Aging Ingredients

NCT01847066
View directory record Official record
Conditions
Wrinkles, Acne Scars, Pigmentation
Interventions
Erbium 2940 plus cosmetics plus Impact, Erbium 2940 plus cosmetics
Device
Lead sponsor
Alma Lasers Inc.
Industry
Eligibility
35 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2013 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical and Histological Evaluation of BTL-785F Device for Non-invasive Treatment of Face

NCT05524662
View directory record Official record
Conditions
Wrinkle
Interventions
BTL-785-7
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

NCT03878381
View directory record Official record
Conditions
Skin Care
Interventions
Skin Care Cream, Placebo
Combination Product · Drug
Lead sponsor
Wayne State University
Other
Eligibility
20 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Jowl Improvement With Injectable Fillers

NCT04389866
View directory record Official record
Conditions
Jowls
Interventions
JUVÉDERM VOLUMA™ XC
Device
Lead sponsor
Advanced Dermatology
Other
Eligibility
35 Years to 75 Years · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lincolnshire, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 14, 2024 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes

NCT00747422
View directory record Official record
Conditions
Periorbital Wrinkles
Interventions
Ulthera™ System
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
40 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
4
States / cities
San Diego, California • Chicago, Illinois • Chestnut Hill, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 5, 2026, 4:17 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Xeomin Treatment of Glabellar Lines Using OLD Versus COLD

NCT05305768
View directory record Official record
Conditions
Glabellar Frown Lines
Interventions
IncobotulinumtoxinA
Drug
Lead sponsor
Clinical Testing of Beverly Hills
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Encino, California • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging

NCT05423873
View directory record Official record
Conditions
Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
Interventions
Gentle Cleansing Lotion, Revision Skincare
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
Solana Beach, California • Greenwood Village, Colorado • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Assessment of the Safety and Effectiveness of a Micro-RF Skin Treatment Device (nebulyft）

NCT06623214
View directory record Official record
Conditions
Wrinkle Reduction
Interventions
nebulyft
Device
Lead sponsor
Hangzhou Rebecca Medical Science and Technology Ltd.
Industry
Eligibility
25 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Gabriel, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Spread of PrabotulinumtoxinA-xvfs Versus OnabotulinumtoxinA in the Treatment of Forehead Rhytides

NCT05807412
View directory record Official record
Conditions
Rhytides
Interventions
PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA
Drug
Lead sponsor
Lupo Center for Aesthetic and General Dermatology
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Sep 5, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BTL-785F Device for Non-invasive Treatment of Wrinkles and Improvement of the Face Appearance

NCT05524805
View directory record Official record
Conditions
Wrinkle
Interventions
BTL-785-7 Treatment
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Greenwood Village, Colorado • Spring Hill, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 5, 2026, 4:17 PM EDT