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ClinicalTrials.gov public records Last synced May 21, 2026, 11:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 271 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Wrinkles Clear all
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Wrinkle
Interventions
Venus Aime
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced May 21, 2026, 11:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Wrinkle, Skin Pigmentation
Interventions
THDA + Acetyl Zingerone Topical Product, THDA
Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
30 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Cosmetic Techniques
Interventions
Onabotulinumtoxina for Injection, Abobotulinumtoxina for Injection, IncobotulinumtoxinA for Injection, PrabotulinumtoxinA for Injection
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 65 Years · Female only
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced May 21, 2026, 11:23 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Aging, Wrinkle, Rhytides
Interventions
Restylane Refyne
Device
Lead sponsor
Siperstein Dermatology
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced May 21, 2026, 11:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel
Device
Lead sponsor
Eric Bernstein, MD
Other
Eligibility
25 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ardmore, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2022 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Skin Rejuvenation, Skin Quality, Wrinkle, Nasolabial Fold
Interventions
PRFM injection, Saline injection
Procedure
Lead sponsor
New York Medical College
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced May 21, 2026, 11:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rockville, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Restylane and Restylane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Benign Pigmented Lesions, Facial Wrinkles
Interventions
PicoWay™ 532nm fractional handpiece, PicoWay™ 730nm wavelength, PicoWay™ 1064nm fractional handpiece
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
21 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Wayland, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Skin Wrinkling
Interventions
Topical 17-beta estradiol in ethanol/propylene glycol (ETOH/PG)
Drug
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 20, 2015 · Synced May 21, 2026, 11:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Unwanted Wrinkles
Interventions
PicoWayTM
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years to 75 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
4
States / cities
Chicago, Illinois • New York, New York • Ardmore, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced May 21, 2026, 11:23 PM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Wrinkle
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Global Aesthetics LLC
Other
Eligibility
20 Years to 65 Years
Enrollment
500 participants
Timeline
2024 – 2027
U.S. locations
2
States / cities
Cisco, Texas • Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Wrinkle, Photoaging, Dyschromia
Interventions
RF device, Microneedling device
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
40 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
3
States / cities
Sacramento, California • Montclair, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Wrinkles, Rhytides
Interventions
TriActive+ RF
Device
Lead sponsor
El. En. SpA
Industry
Eligibility
30 Years to 60 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Indianapolis, Indiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Fine Lines, Wrinkles, Laxity; Skin
Interventions
Gentle Cleanser, Facial Moisturizer, sunscreen SPF 30
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Wrinkle
Interventions
GAL1906
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older · Female only
Enrollment
211 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
14
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Redondo Beach, California + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Periorbital Wrinkles
Interventions
Ulthera® System treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Hunt Valley, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced May 21, 2026, 11:23 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Skin Wrinkles on Face and Neck Areas
Interventions
Activation Mist
Other
Lead sponsor
California Allergy and Asthma Medical Group, Inc.
Other
Eligibility
30 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 10, 2013 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Wrinkle, Benign Pigmented Lesions, Benign Vascular Lesions
Interventions
TempSure, Icon
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
3
States / cities
Westford, Massachusetts • Portsmouth, New Hampshire • Huntersville, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Fine Lines, Wrinkle, Photoaging
Interventions
Anti-aging Serum, Facial Moisturizer, Cleansing Lotion, Sunscreen
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
30 Years to 60 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced May 21, 2026, 11:23 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Glabellar Frown Lines
Interventions
onabotulinumtoxinA at a depth of 2mm, onabotulinumtoxinA at a depth of 4mm
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced May 21, 2026, 11:23 PM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Décolleté Wrinkles
Interventions
Radiesse
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
40 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Alpharetta, Georgia
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced May 21, 2026, 11:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Lateral Canthal Lines
Interventions
RT001, Placebo
Drug · Other
Lead sponsor
Revance Therapeutics, Inc.
Industry
Eligibility
30 Years to 60 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
9
States / cities
Birmingham, Alabama • San Francisco, California • Coral Gables, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2014 · Synced May 21, 2026, 11:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Wrinkle
Interventions
BTL-785-2, No Treatment
Device · Other
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced May 21, 2026, 11:23 PM EDT