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Filters: Condition: Xerostomia Due to Radiotherapy Clear all

Completed Phase 1 Interventional

A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia

NCT04043104

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Conditions: Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy, Head and Neck Cancer
Interventions: AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland), AAV2hAQP1: 1 x 10^11 vg/gland (both glands), AAV2hAQP1: 1 x 10^12 vg/gland (single gland), AAV2hAQP1: 3 x 10^11 vg/gland (both glands), AAV2hAQP1: 3 x 10^12 vg/gland (single gland), AAV2hAQP1: 1 x 10^12 vg/gland (both glands); Drug
Lead sponsor: MeiraGTx UK II Ltd; Industry
Eligibility: 18 Years and older

Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 5
States / cities: Stanford, California • Louisville, Kentucky • Boston, Massachusetts + 2 more

Source: ClinicalTrials.gov public record

Updated Apr 23, 2023 · Synced May 22, 2026, 12:15 AM EDT

Completed Not applicable Interventional

Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx

NCT03418792

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Conditions: Head and Neck Cancer, Oropharynx Cancer, Xerostomia Due to Radiotherapy
Interventions: Parotid-Sparing Head & Neck Radiation Guided by MRI Sialography; Other
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 18 Years and older

Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Source: ClinicalTrials.gov public record

Updated May 30, 2023 · Synced May 22, 2026, 12:15 AM EDT

Withdrawn Phase 1Phase 2 Interventional

Stromal Vascular Fraction for Treatment of Xerostomia

NCT03061110

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Conditions: Xerostomia Due to Radiotherapy (Disorder)
Interventions: Stromal Vascular Fraction, Usual Care; Biological · Other
Lead sponsor: Midwestern Regional Medical Center; Other
Eligibility: 21 Years and older

Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Zion, Illinois

Source: ClinicalTrials.gov public record

Updated Apr 29, 2018 · Synced May 22, 2026, 12:15 AM EDT