A Randomized Study Comparing the Safety and Efficacy of Two Regimens of Oral Ganciclovir to Intravenous Ganciclovir Maintenance Therapy for Cytomegalovirus Retinitis in People With AIDS Who Have Received Prior Ganciclovir Therapy
Public ClinicalTrials.gov record NCT00002247. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To compare the safety and tolerance of oral ganciclovir at a double dose 3 times/day or a single dose 6 times/day to IV ganciclovir given for 20 weeks of maintenance therapy. To compare the time to progression of cytomegalovirus (CMV) retinitis between two regimens of oral ganciclovir and IV ganciclovir therapy given for 20 weeks of maintenance therapy. To describe the efficacy and safety of double dose versus single dose oral ganciclovir in patients who have a progression of retinitis while on the originally assigned maintenance treatment. To describe the safety, tolerance, and time to progression of retinitis during the 52 weeks of oral ganciclovir maintenance therapy in people with AIDS. To describe the safety and tolerance of oral ganciclovir maintenance therapy when given concurrently with antiretroviral treatment (e.g., zidovudine, ddI, or ddC). To describe survival of people with AIDS and CMV retinitis.
Study identification
- NCT ID
- NCT00002247
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 225 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 13 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Not listed
- Primary completion
- Not listed
- Completion
- Not listed
- Last update posted
- Jun 24, 2005
United States locations
- U.S. sites
- 19
- U.S. states
- 11
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East Bay AIDS Ctr | Berkeley | California | 94704 | — |
| AIDS Clinical Research Ctr / UCLA Med Ctr | Los Angeles | California | 900951793 | — |
| UCSD Med Ctr / Pediatrics | San Diego | California | 92103 | — |
| San Francisco Gen Hosp | San Francisco | California | 941102859 | — |
| Davies Med Ctr / c/o HIV Institute | San Francisco | California | 94114 | — |
| Mount Zion Med Ctr | San Francisco | California | 94115 | — |
| Dr David Busch | San Francisco | California | 94118 | — |
| Georgetown Univ Med Ctr | Washington D.C. | District of Columbia | 20007 | — |
| Miami Veterans Administration Med Ctr | Miami | Florida | 33125 | — |
| AIDS Research Consortium of Atlanta | Atlanta | Georgia | 30308 | — |
| Margo Heath - Chiozzi | Honolulu | Hawaii | 96816 | — |
| Rush Presbyterian - Saint Luke's Med Ctr / Rush Med Coll | Chicago | Illinois | 60612 | — |
| Beth Israel Hosp | Boston | Massachusetts | 02215 | — |
| Dr Dorothy Friedberg | New York | New York | 10016 | — |
| Cornell Univ Med College | New York | New York | 10021 | — |
| Buckley Braffman Stern Med Associates | Philadelphia | Pennsylvania | 19107 | — |
| Oak Lawn Physicians Group | Dallas | Texas | 75219 | — |
| Univ TX Galveston Med Branch | Galveston | Texas | 77550 | — |
| Univ of Washington / Pacific Med Ctr | Seattle | Washington | 98144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00002247, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 24, 2005 · Synced Nov 6, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00002247 live on ClinicalTrials.gov.