Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
Public ClinicalTrials.gov record NCT00003070. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
Afterload Reduction Therapy for Late Anthracycline Cardiotoxicity: A Pediatric Oncology Group Cancer Control Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy. It is not known whether enalapril is more effective than a placebo in treating heart damage in patients who received anthracycline chemotherapy for childhood cancer. PURPOSE: Randomized double-blinded phase III trial to compare the effectiveness of enalapril with a placebo in treating heart damage in patients who received anthracycline chemotherapy for childhood cancer.
Study identification
- NCT ID
- NCT00003070
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 13 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 8 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2000 (Type not available)
- Primary completion
- Jul 2003 (Actual)
- Completion
- Mar 2007 (Actual)
- Last update posted
- Aug 5, 2014
2000 – 2007
United States locations
- U.S. sites
- 55
- U.S. states
- 27
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | 35294-3300 | — |
| MBCCOP - Gulf Coast | Mobile | Alabama | 36688 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| University of California San Diego Cancer Center | La Jolla | California | 92093-0658 | — |
| Lucile Packard Children's Hospital at Stanford | Palo Alto | California | 94304 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Yale Comprehensive Cancer Center | New Haven | Connecticut | 06520-8028 | — |
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307-5000 | — |
| Shands Hospital and Clinics, University of Florida | Gainesville | Florida | 32610-100277 | — |
| Sylvester Cancer Center, University of Miami | Miami | Florida | 33136 | — |
| Miami Children's Hospital | Miami | Florida | 33155 | — |
| CCOP - Florida Pediatric | Tampa | Florida | 33682-7757 | — |
| Emory University Hospital - Atlanta | Atlanta | Georgia | 30322 | — |
| Cancer Research Center of Hawaii | Honolulu | Hawaii | 96813 | — |
| Children's Memorial Hospital, Chicago | Chicago | Illinois | 60614 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160-7357 | — |
| CCOP - Wichita | Wichita | Kansas | 67214-3882 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| CCOP - Ochsner | New Orleans | Louisiana | 70121 | — |
| Ochsner Clinic | New Orleans | Louisiana | 70121 | — |
| Marlene & Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | 21201 | — |
| Johns Hopkins Oncology Center | Baltimore | Maryland | 21231-2410 | — |
| Boston Floating Hospital Infants and Children | Boston | Massachusetts | 02111 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Children's Hospital of Michigan | Detroit | Michigan | 48201 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| Cardinal Glennon Children's Hospital | St Louis | Missouri | 63104 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| CCOP - Northern New Jersey | Hackensack | New Jersey | 07601 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263-0001 | — |
| Schneider Children's Hospital | New Hyde Park | New York | 11042 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| University of Rochester Cancer Center | Rochester | New York | 14642 | — |
| State University of New York - Upstate Medical University | Syracuse | New York | 13210 | — |
| Mission Saint Joseph's Health System | Asheville | North Carolina | 28801 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28232-2861 | — |
| Presbyterian Healthcare | Charlotte | North Carolina | 28233-3549 | — |
| Duke Comprehensive Cancer Center | Durham | North Carolina | 27710 | — |
| East Carolina University School of Medicine | Greenville | North Carolina | 27858-4354 | — |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | 27157-1082 | — |
| Oklahoma Memorial Hospital | Oklahoma City | Oklahoma | 73126-0307 | — |
| CCOP - Columbia River Program | Portland | Oregon | 97213 | — |
| St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | 19134-1095 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425-0721 | — |
| Children's Hospital of Greenville Hospital System | Greenville | South Carolina | 29605 | — |
| Saint Jude Children's Research Hospital | Memphis | Tennessee | 38105-2794 | — |
| Simmons Cancer Center - Dallas | Dallas | Texas | 75235-9154 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| MBCCOP - South Texas Pediatric | San Antonio | Texas | 78229-3900 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78284-7811 | — |
| Naval Medical Center, Portsmouth | Portsmouth | Virginia | 23708-2197 | — |
| Massey Cancer Center | Richmond | Virginia | 23298-0037 | — |
| Midwest Children's Cancer Center | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00003070, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2014 · Synced Nov 10, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00003070 live on ClinicalTrials.gov.