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Completed Phase 1 Interventional

Tipifarnib in Treating Young Patients With Refractory Leukemia

ClinicalTrials.gov ID: NCT00022451

Public ClinicalTrials.gov record NCT00022451. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Nov 4, 2026, 7:06 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I Trial and Pharmacokinetic Study of R115777 in Pediatric Patients With Refractory Leukemia

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

RATIONALE: Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase I trial to study the effectiveness of tipifarnib in treating young patients who have refractory leukemia.

Study identification

NCT ID
NCT00022451
Recruitment status
Completed
Study type
Interventional
Phase
Phase 1
Enrollment
Not listed

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range
Up to 21 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 2001 (Type not available)
Primary completion
Not listed
Completion
Mar 2005 (Actual)
Last update posted
Mar 15, 2012

2001 – 2005

United States locations

U.S. sites
56
U.S. states
28
U.S. cities
49
Facility City State ZIP Site status
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock Arkansas 72205 —
City of Hope Comprehensive Cancer Center Duarte California 91010-3000 —
Rebecca and John Moores UCSD Cancer Center La Jolla California 92093-0658 —
Children's Hospital Los Angeles Los Angeles California 90027-0700 —
Jonsson Comprehensive Cancer Center, UCLA Los Angeles California 90095-1781 —
Children's Hospital of Orange County Orange California 92868 —
UCSF Comprehensive Cancer Center San Francisco California 94143 —
Stanford Cancer Center at Stanford University Medical Center Stanford California 94305-5208 —
Children's National Medical Center Washington D.C. District of Columbia 20010-2970 —
Shands Cancer Center at the University of Florida Health Science Center Gainesville Florida 32610-0296 —
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus Atlanta Georgia 30342 —
MBCCOP-Medical College of Georgia Cancer Center Augusta Georgia 30912-4000 —
Children's Memorial Hospital - Chicago Chicago Illinois 60614 —
Riley Children Cancer Center at Riley Hospital for Children Indianapolis Indiana 46202-5225 —
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City Kansas 66160-7357 —
MBCCOP - LSU Health Sciences Center New Orleans Louisiana 70112 —
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore Maryland 21231-7223 —
Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda Maryland 20892-1182 —
Floating Hospital for Children Boston Massachusetts 02111 —
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston Massachusetts 02115 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109-0914 —
Children's Hospital of Michigan Detroit Michigan 48201 —
University of Minnesota Cancer Center Minneapolis Minnesota 55455 —
Mayo Clinic Cancer Center Rochester Minnesota 55905 —
University of Mississippi Medical Center Jackson Mississippi 39216-4505 —
Children's Mercy Hospital Kansas City Missouri 64108 —
Cardinal Glennon Children's Hospital St Louis Missouri 63104 —
St. Louis Children's Hospital St Louis Missouri 63110 —
Cancer Center at Hackensack University Medical Center Hackensack New Jersey 07601 —
Cancer Institute of New Jersey at Robert Wood Johnson University Hospital New Brunswick New Jersey 08901 —
NYU School of Medicine's Kaplan Comprehensive Cancer Center New York New York 10016 —
Memorial Sloan-Kettering Cancer Center New York New York 10021 —
Herbert Irving Comprehensive Cancer Center at Columbia University New York New York 10032 —
SUNY Upstate Medical University Hospital Syracuse New York 13210 —
Duke Comprehensive Cancer Center Durham North Carolina 27710 —
Cincinnati Children's Hospital Medical Center Cincinnati Ohio 45229-3039 —
Columbus Children's Hospital Columbus Ohio 43205-2696 —
Oklahoma University Medical Center Oklahoma City Oklahoma 73126 —
CCOP - Columbia River Oncology Program Portland Oregon 97225 —
Children's Hospital of Philadelphia Philadelphia Pennsylvania 19104-4318 —
Children's Hospital of Pittsburgh Pittsburgh Pennsylvania 15213-2583 —
Hollings Cancer Center at Medical University of South Carolina Charleston South Carolina 29425-0721 —
St. Jude Children's Research Hospital Memphis Tennessee 38105-2794 —
Vanderbilt Children's Hospital Nashville Tennessee 37232-6310 —
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas Texas 75390-9063 —
Cook Children's Medical Center - Fort Worth Fort Worth Texas 76104 —
Texas Children's Cancer Center Houston Texas 77030-2399 —
University of Texas - MD Anderson Cancer Center Houston Texas 77030-4009 —
University of Texas Health Science Center at San Antonio San Antonio Texas 78207 —
MBCCOP - South Texas Pediatrics San Antonio Texas 78229-3900 —
CCOP - Scott and White Hospital Temple Texas 76508 —
Huntsman Cancer Institute Salt Lake City Utah 84112 —
Children's Hospital and Regional Medical Center - Seattle Seattle Washington 98105 —
University of Wisconsin Comprehensive Cancer Center Madison Wisconsin 53792-6164 —
CCOP - Marshfield Clinic Research Foundation Marshfield Wisconsin 54449 —
Midwest Children's Cancer Center Milwaukee Wisconsin 53226 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00022451, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 15, 2012 · Synced Nov 4, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00022451 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →