Trial With HuMax-CD4 in Participants With Rheumatoid Arthritis (RA) Failing Treatment With Methotrexate (MTX) and a TNF-alpha Blocker
Public ClinicalTrials.gov record NCT00042406. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Randomized, Parallel Group Clinical Trial of Anti-CD4 Receptor Human Monoclonal Antibody (HuMax-CD4) in Patients With Active Rheumatoid Arthritis Failing Treatment With Methotrexate and TNF-alpha Blocking Agents
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether HuMax-CD4 is effective in the treatment of active RA in participants who have failed treatment with MTX and at least one TNF-alpha blocking agent.
Study identification
- NCT ID
- NCT00042406
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 83 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2002 (Actual)
- Primary completion
- Mar 31, 2003 (Actual)
- Completion
- Mar 31, 2003 (Actual)
- Last update posted
- Apr 28, 2023
2002 – 2003
United States locations
- U.S. sites
- 50
- U.S. states
- 25
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheumatology Associates | Montgomery | Alabama | 36111-2654 | — |
| Pro Health Partners, Inc. | Long Beach | California | 90813-3412 | — |
| Rheumatology & Internal Medicine, Boling Clinical Trials | Rancho Cucamonga | California | 91730 | — |
| Advances in Medicine | Rancho Mirage | California | 92270 | — |
| Radiant Research, Inc. | San Diego | California | 92108 | — |
| West Coast Clinical Research | Van Nuys | California | 91405 | — |
| Arthritis Center of CT | Waterbury | Connecticut | 06708 | — |
| Arthritis Associates of South Florida | Delray Beach | Florida | 33484 | — |
| Ocala Rheumatology Research Center | Ocala | Florida | 34474 | — |
| nTouch Research | St. Petersburg | Florida | 33707 | — |
| Radiant Research, Inc. | Stuart | Florida | 34996 | — |
| Tampa Medical Group Research | Tampa | Florida | 33614 | — |
| nTouch Research | Decatur | Georgia | 30033 | — |
| North Western Center for Clinical Research | Chicago | Illinois | 60611 | — |
| Rheumatology Associates, P.C. | Chicago | Illinois | 60612 | — |
| Advocate Medical Group | Park Ridge | Illinois | 60068 | — |
| The Arthritis Center | Springfield | Illinois | 62704 | — |
| Deerbrook Medical Associates | Vernon Hills | Illinois | 60061 | — |
| West Pharmaceutical Services | Evansville | Indiana | 47714 | — |
| Idaho Arthritis & Osteoporosis Center | Meridian Hills | Indiana | 83642 | — |
| Mercy Arthritis Center | Des Moines | Iowa | 50322 | — |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| Osteoporosis and Clinical Trials Center | Hagerstown | Maryland | 21740 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Arthritis Education and Treatment Center | Grand Rapids | Michigan | 49503 | — |
| Midwest Arthritis Center | Kalamazoo | Michigan | 49001 | — |
| Fiechtner Research | Lansing | Michigan | 48910 | — |
| Westroads Medical Group | Omaha | Nebraska | 68114 | — |
| Arthritis Center of Reno | Reno | Nevada | 89502 | — |
| One Crouse Medical Plaza | Syracuse | New York | 13210 | — |
| C.A.R.E. Center | Raleigh | North Carolina | 27609 | — |
| DataPharm, Inc. | Canfield | Ohio | 44406 | — |
| Disease Study Group / Deaconess Hospital | Cincinnati | Ohio | 45219 | — |
| Lynn Health Science | Oklahoma City | Oklahoma | 73112 | — |
| Bend Memorial Clinic | Bend | Oregon | 97701 | — |
| Rheumatology Clinic | Medford | Oregon | 97504 | — |
| Providence Arthritis Center | Portland | Oregon | 97213 | — |
| Northwest Rheumatology Associates, PC | Portland | Oregon | 97225 | — |
| East Pennsylvania Rheumatology | Bethlehem | Pennsylvania | 18015 | — |
| Altoona Arthritis & Osteoporosis Center | Duncansville | Pennsylvania | 16635-0909 | — |
| Clinical Research Center of Reading | West Reading | Pennsylvania | 19611 | — |
| Presbyterian Hospital of Dallas | Dallas | Texas | 75231 | — |
| IHC Clinical Research Foundation | Salt Lake City | Utah | 84102 | — |
| Medical College of Virginia, Div. of Rheum. | Richmond | Virginia | 23298-0647 | — |
| Lewis Gayle Clinic | Salem | Virginia | 24153 | — |
| Evergreen Medical & Dental Center | Kirkland | Washington | 98034 | — |
| South Puget Sound Clinical Research Center | Olympia | Washington | 98502 | — |
| Minor & James Med., First Hill Medical Building | Seattle | Washington | 98104 | — |
| Internal Medicine Association of Yakima, Inc., P.S. | Yakima | Washington | 98902 | — |
| Medical Arts Center | Milwaukee | Wisconsin | 53211 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00042406, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2023 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00042406 live on ClinicalTrials.gov.