Secondary Prevention of Small Subcortical Strokes Trial
Public ClinicalTrials.gov record NCT00059306. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Secondary Prevention of Small Subcortical Strokes (SPS3) Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to learn if combination antiplatelet therapy (aspirin and clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and cognitive decline, and if intensive blood pressure control is associated with fewer recurrent strokes and cognitive decline. On July 21, 2011 the DSMB recommended terminating the anti platelet arm of the study due to an imbalance of overall and major non-CNS hemorrhagic SAE's and total deaths in the investigational anti platelet combination of aspirin + clopidogrel and an interim statistical analysis that demonstrated futility in the investigational anti platelet arm. It was recommended that patients be continued on standard care of aspirin mono therapy until their study close-out visit. Also, recommended the continuation and completion of the plood pressure arm following the protocol.
Study identification
- NCT ID
- NCT00059306
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,020 participants
Conditions and interventions
Conditions
Interventions
- aspirin Drug
- clopidogrel Drug
- Target of Blood Pressure Other
- placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 30 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2003 (Type not available)
- Primary completion
- Apr 2012 (Actual)
- Completion
- Apr 2012 (Actual)
- Last update posted
- Apr 4, 2013
2003 – 2012
United States locations
- U.S. sites
- 39
- U.S. states
- 22
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern Alabama Stroke Center | Mobile | Alabama | 36617 | — |
| Catholic Healthcare West | Phoenix | Arizona | 85013 | — |
| Mayo Clinic Scottsdale | Scottsdale | Arizona | 85259 | — |
| University of Arizona, Department of Neurology | Tucson | Arizona | 85724 | — |
| University of California San Diego Medical Center | San Diego | California | 92103-8466 | — |
| University of California San Francisco-Fresno | San Francisco-Fresno | California | — | — |
| Denver | Englewood | Colorado | — | — |
| Melbourne | Melbourne | Florida | — | — |
| Miami-University of Miami, Miller School of Medicine | Miami | Florida | 33136 | — |
| Emory University, Grady Health System | Atlanta | Georgia | 30303 | — |
| Mercy Medical Center-Ruan Neurology Clinical Research | Des Moines | Iowa | 50314 | — |
| University of Kentucky, Aging/Stroke Program | Lexington | Kentucky | 40506-0230 | — |
| Suburban Hospital | Bethesda | Maryland | — | — |
| Boston University | Boston | Massachusetts | 02118 | — |
| Wayne State | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital, Department of Neurology | Detroit | Michigan | 48202 | — |
| Berman Center | Minneapolis | Minnesota | 55404 | — |
| Mayo Stroke Center KA-SL-13 | Rochester | Minnesota | 55905 | — |
| University of Washington | Sant Louis | Missouri | — | — |
| Tenet Health, St. Louis University | St Louis | Missouri | 63110 | — |
| St. John's Mercy | St Louis | Missouri | 63141 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Buffalo | Buffalo | New York | — | — |
| Helen Hayes Hospital | Haverstraw | New York | 10993 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Rochester General Hospital | Rochester | New York | 14621 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Wake Forest University, Sciences-Neurology | Winston-Salem | North Carolina | 27157-1078 | — |
| Case Western | Cleveland | Ohio | 44106 | — |
| Metrohealth Medical Center | Cleveland | Ohio | 44109 | — |
| Ohio State University, Division of Stroke | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern | Dallas | Texas | 75390-8897 | — |
| Scurlock Stroke Center | Houston | Texas | 77030 | — |
| University of Texas Health Science Center | San Antonio | Texas | 78229-3900 | — |
| University of Washington | Seattle | Washington | 98104-2499 | — |
| Marshfield Clinic, Department of Neurology | Marshfield | Wisconsin | 54449 | — |
| Medical College of Wisconsin-Neurology | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00059306, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 4, 2013 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00059306 live on ClinicalTrials.gov.