ESCAPE Migraine Trial
Public ClinicalTrials.gov record NCT00267371. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effect of Septal Closure of Atrial PFO on Events of Migraine With Premere: ESCAPE Migraine Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this two arm controlled double-blind study is to determine the safety and effectiveness of PFO closure (closing a hole in the wall of the heart) in reducing the frequency of migraine headaches, in patients who experience migraine headaches and have a PFO, compared to medical therapy alone.
Study identification
- NCT ID
- NCT00267371
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 168 participants
Conditions and interventions
Conditions
Interventions
- PFO Closure with Premere investigational device. Device
- Medical management/current medications per standard of care by personal physician. Drug
Device · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2005 (Type not available)
- Primary completion
- Mar 2012 (Actual)
- Completion
- Mar 2012 (Actual)
- Last update posted
- Feb 4, 2019
2005 – 2012
United States locations
- U.S. sites
- 37
- U.S. states
- 19
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Scottsdale | Arizona | 85054 | — |
| Newport Beach Clinical Research Associates, Inc. | Newport Beach | California | 92660 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| Alpine Clinical Research Center | Boulder | Colorado | 80304 | — |
| Mile High Research Center | Denver | Colorado | 80218 | — |
| Advanced Neurosciences Research, LLC | Fort Collins | Colorado | 80528 | — |
| Hartford Headache Center | East Hartford | Connecticut | 06118 | — |
| Medstar Clinical Research at Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Neurology Associates | Maitland | Florida | 32751 | — |
| Intercoastal Neurology | Sarasota | Florida | 34232 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Neurology Specialists of Decatur | Decatur | Georgia | 30033 | — |
| Evanston Northwestern HealthCare | Evanston | Illinois | 60201 | — |
| Mid-Atlantic Headache Institute | Pikesville | Maryland | 21208 | — |
| Stroke + NeuroCritical Care Stroke Service | Boston | Massachusetts | 02114 | — |
| New England Regional Headache Center | Worcester | Massachusetts | 01605 | — |
| Providence Hospital & Medical Centers, Inc. | Southfield | Michigan | 48075 | — |
| Mercy Health Research-Neurology | St Louis | Missouri | 63141 | — |
| Radiant Research | St Louis | Missouri | 63141 | — |
| Shore Neurology, PA | Toms River | New Jersey | 08755 | — |
| Upstate Clinical Research, LLC | Albany | New York | 12205 | — |
| MedARK Clinical Research | Morganton | North Carolina | 28655 | — |
| Clinical Research of Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Univ. Health Sciences - BMC | Winston-Salem | North Carolina | 27157 | — |
| Guilford Neurologic Associates, Inc. | Winston-Salem | North Carolina | 27401 | — |
| Neurology and Sleep Medicine, P.C. | Bethlehem | Pennsylvania | 18015 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Clinical Trials Research Services, LLC | Pittsburgh | Pennsylvania | 15206 | — |
| HAN Neurological Associates | Upland | Pennsylvania | 19013 | — |
| Bellaire Neurology, PA | Bellaire | Texas | 77401 | — |
| Texas Neurology, PA | Dallas | Texas | 75214 | — |
| Houston Headache Clinic | Houston | Texas | 77004 | — |
| University of Virginia Neurology | Charlottesville | Virginia | 22903 | — |
| Commonwealth Clinical Research Specialists, Inc. | Richmond | Virginia | 23233 | — |
| Brighton Research Group, LLC | Virginia Beach | Virginia | 23452 | — |
| Swedish Pain & Headache Specialist | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00267371, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 4, 2019 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00267371 live on ClinicalTrials.gov.