Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection
Public ClinicalTrials.gov record NCT00300274. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 24-month, Multi-center, Randomized, Open-label, Non-inferiority Study of Efficacy and Safety Comparing Two Exposures of Concentration-controlled Everolimus With Reduced Cyclosporine Versus 3.0 g Mycophenolate Mofetil With Standard Dose Cyclosporine in de Novo Heart Transplant Recipients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial was to examine the impact of everolimus and reduced dose of cyclosporine on efficacy and safety compared to mycophenolate mofetil and a standard dose of cyclosporine in heart transplant recipients.
Study identification
- NCT ID
- NCT00300274
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 721 participants
Conditions and interventions
Conditions
Interventions
- everolimus Drug
- mycophenolate mofetil Drug
- cyclosporine Drug
- corticosteroids Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2006 (Type not available)
- Primary completion
- Jul 2011 (Actual)
- Completion
- Jul 2011 (Actual)
- Last update posted
- Aug 16, 2012
2006 – 2011
United States locations
- U.S. sites
- 26
- U.S. states
- 15
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCLA Medical Center | Los Angeles | California | — | — |
| California Pacific Medical Center | San Francisco | California | — | — |
| Stanford U Sch, Falk Cardiovasular Research Ctr. | Stanford | California | — | — |
| University of Florida Shands Hospital | Gainesville | Florida | — | — |
| Emory University Hospital | Atlanta | Georgia | — | — |
| Loyola Univerisity Medical School | Maywood | Illinois | — | — |
| Massachusetts General Hospital | Boston | Massachusetts | — | — |
| Tufts Medical Center | Boston | Massachusetts | — | — |
| University of Michigan Health System | Ann Arbor | Michigan | — | — |
| Washington University School of Medicine | St Louis | Missouri | — | — |
| Columbia University Medical Center | New York | New York | — | — |
| Recanati Miller Transplant Institute | New York | New York | — | — |
| UNC Division of Cardiology | Chapel Hill | North Carolina | — | — |
| Duke University Heart Failure Research | Durham | North Carolina | — | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | — | — |
| Penn State College of Medicine | Hershey | Pennsylvania | — | — |
| Hahnemann University Hospital | Philadelphia | Pennsylvania | — | — |
| Temple University Hospital | Philadelphia | Pennsylvania | — | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | — | — |
| Medical University of South Carolina | Charleston | South Carolina | — | — |
| Texas Cardiovascular Consultants | Austin | Texas | — | — |
| University of Texas Medical Branch, Div of Cardio Thoracic | Galveston | Texas | — | — |
| Methodist Hospital/DeBakey Heart Failure Research Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | — | — |
| University of Wisconsin - Madison Medical School | Madison | Wisconsin | 53792 | — |
| St. Luke's Medical Center Cardiac Services | Milwakee | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 38 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00300274, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2012 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00300274 live on ClinicalTrials.gov.