Age-Related Eye Disease Study 2 (AREDS2)
Public ClinicalTrials.gov record NCT00345176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Age-Related Eye Disease Study 2 (AREDS2): A Multi-center, Randomized Trial of Lutein, Zeaxanthin and Omega-3 Long-Chain Polyunsaturated Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). Observational data suggest that increased dietary intake of lutein + zeaxanthin (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid \[DHA\] + eicosapentaenoic acid \[EPA\]), or both might further reduce this risk. AREDS2 was designed to test whether adding lutein + zeaxanthin, DHA + EPA, or lutein + zeaxanthin and DHA + EPA to the AREDS formulation might further reduce the risk of progression to advanced AMD. A secondary goal was to test the effects of eliminating beta carotene and reducing zinc dose in the AREDS formulation.
Study identification
- NCT ID
- NCT00345176
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,203 participants
Conditions and interventions
Conditions
Interventions
- Lutein/zeaxanthin Dietary Supplement
- DHA/EPA Dietary Supplement
- Lutein/zeaxanthin and DHA/EPA Drug
Dietary Supplement · Drug
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2006 (Type not available)
- Primary completion
- Oct 2012 (Actual)
- Completion
- Oct 2012 (Actual)
- Last update posted
- May 5, 2015
2006 – 2012
United States locations
- U.S. sites
- 91
- U.S. states
- 30
- U.S. cities
- 75
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Jones Eye Institute - UAMS | Little Rock | Arkansas | 72205 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Shiley Eye Center - UCSD | La Jolla | California | 92093 | — |
| Loma Linda University | Loma Linda | California | 92354 | — |
| Doheny Eye Institute | Los Angeles | California | 90033 | — |
| Jules Stein Eye Institute | Los Angeles | California | 90095 | — |
| VA Northern California Health Care System | Martinez | California | 94553 | — |
| Southern California Desert Retina Consultants, MC | Palm Springs | California | 92262 | — |
| University of California, Davis | Sacramento | California | 95817 | — |
| West Coast Retina Medical Group, Inc | San Francisco | California | 94107 | — |
| Pacific Eye Associates | San Francisco | California | 94115 | — |
| Colorado Retina Associates | Denver | Colorado | 80218 | — |
| Eldorado Retina Associates, PC | Louisville | Colorado | 80027 | — |
| Yale University Eye Center | New Haven | Connecticut | 06510 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33334 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Sarasota Retina Institute | Sarasota | Florida | 34239 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Emory University Eye Center | Atlanta | Georgia | 30322 | — |
| Georgia Retina, PC | Decatur | Georgia | 30030 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| The University of Illinois | Chicago | Illinois | 60612 | — |
| NorthShore University HealthSystems | Glenview | Illinois | 60026 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Elman Retina Group | Baltimore | Maryland | 21237 | — |
| Wilmer Eye Institute, Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| National Eye Institute | Bethesda | Maryland | 20892 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Massachusetts Eye and Ear Infirmary | Boston | Massachusetts | 02114 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Kresge Eye Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Health System - Eye Care Services | Detroit | Michigan | 48202 | — |
| Vision Research Foundation | Grand Rapids | Michigan | 49546 | — |
| Vision Research Foundation | Royal Oak | Michigan | 48073 | — |
| Vision Research Foundation | Traverse City | Michigan | 49686 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University Health Care - Mason Eye Institute | Columbia | Missouri | 65212 | — |
| Eye Foundation of Kansas City | Kansas City | Missouri | 64108 | — |
| Mid-America Retina Consultants, PA | Kansas City | Missouri | 64111 | — |
| The Retina Institute | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Delaware Valley Retina Associates | Lawrenceville | New Jersey | 08648 | — |
| UMDNJ | Newark | New Jersey | 07103 | — |
| Ophthalmic Consultants of Long Island | Lynbrook | New York | 11563 | — |
| New York Eye and Ear Infirmary | New York | New York | 10003 | — |
| Manhattan Eye, Ear and Throat Hospital | New York | New York | 10021 | — |
| University of Rochester Eye Institute | Rochester | New York | 14642 | — |
| Retina Consultants, PLLC | Slingerlands | New York | 12159 | — |
| The Research Foundation of SUNY/Stony Brook | Stony Brook | New York | 11794 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | — |
| UNC Department of Ophthalmology | Chapel Hill | North Carolina | 27599 | — |
| Charlotte Eye Ear Nose and Throat Associates | Charlotte | North Carolina | 28210 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Wake Forest University Eye Center | Winston-Salem | North Carolina | 27157 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Retina Associates of Cleveland | Cleveland | Ohio | 44122 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Retina Associates of Cleveland | Middleburg Heights | Ohio | 44130 | — |
| Retina Associates of Cleveland | Youngstown | Ohio | 44505 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| Devers Eye Institute | Portland | Oregon | 97210 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Pennsylvania Retina Specialists, PC | Camp Hill | Pennsylvania | 17011 | — |
| Penn State M.S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Scheie Eye Institute | Philadelphia | Pennsylvania | 19104 | — |
| Wills Eye Hospital/Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Retina Vitreous Consultants | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Palmetto Retina Center | Columbia | South Carolina | 29204 | — |
| Carolina Retina Center | Columbia | South Carolina | 29223 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37909 | — |
| University of Tennessee | Memphis | Tennessee | 38163 | — |
| Vanderbilt Eye Institute | Nashville | Tennessee | 37232 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| John Moran Eye Center | Salt Lake City | Utah | 84132 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| The Retina Group of Washington | Fairfax | Virginia | 22031 | — |
| Retina Center Northwest | Silverdale | Washington | 98383 | — |
| University of Wisconsin | Madison | Wisconsin | 53705 | — |
| The Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00345176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2015 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00345176 live on ClinicalTrials.gov.