ClinicalTrials.gov record
Age-Related Eye Disease Study 2 (AREDS2)
ClinicalTrials.gov ID: NCT00345176
Public ClinicalTrials.gov record NCT00345176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 21, 2026, 1:21 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Age-Related Eye Disease Study 2 (AREDS2): A Multi-center, Randomized Trial of Lutein, Zeaxanthin and Omega-3 Long-Chain Polyunsaturated Fatty Acids (Docosahexaenoic Acid [DHA] and Eicosapentaenoic Acid [EPA]) in Age-Related Macular Degeneration
Study identification
- NCT ID
- NCT00345176
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- National Eye Institute (NEI)
- NIH
- Enrollment
- 4,203 participants
Conditions and interventions
Conditions
Interventions
- DHA/EPA Dietary Supplement
- Lutein/zeaxanthin Dietary Supplement
- Lutein/zeaxanthin and DHA/EPA Drug
Dietary Supplement · Drug
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2006
- Primary completion
- Sep 30, 2012
- Completion
- Sep 30, 2012
- Last update posted
- May 4, 2015
2006 – 2012
United States locations
- U.S. sites
- 91
- U.S. states
- 30
- U.S. cities
- 75
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Jones Eye Institute - UAMS | Little Rock | Arkansas | 72205 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Shiley Eye Center - UCSD | La Jolla | California | 92093 | — |
| Loma Linda University | Loma Linda | California | 92354 | — |
| Doheny Eye Institute | Los Angeles | California | 90033 | — |
| Jules Stein Eye Institute | Los Angeles | California | 90095 | — |
| VA Northern California Health Care System | Martinez | California | 94553 | — |
| Southern California Desert Retina Consultants, MC | Palm Springs | California | 92262 | — |
| University of California, Davis | Sacramento | California | 95817 | — |
| West Coast Retina Medical Group, Inc | San Francisco | California | 94107 | — |
| Pacific Eye Associates | San Francisco | California | 94115 | — |
| Colorado Retina Associates | Denver | Colorado | 80218 | — |
| Eldorado Retina Associates, PC | Louisville | Colorado | 80027 | — |
| Yale University Eye Center | New Haven | Connecticut | 06510 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33334 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Sarasota Retina Institute | Sarasota | Florida | 34239 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Emory University Eye Center | Atlanta | Georgia | 30322 | — |
| Georgia Retina, PC | Decatur | Georgia | 30030 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| The University of Illinois | Chicago | Illinois | 60612 | — |
| NorthShore University HealthSystems | Glenview | Illinois | 60026 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Elman Retina Group | Baltimore | Maryland | 21237 | — |
| Wilmer Eye Institute, Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| National Eye Institute | Bethesda | Maryland | 20892 | — |
| The Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Massachusetts Eye and Ear Infirmary | Boston | Massachusetts | 02114 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Kresge Eye Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Health System - Eye Care Services | Detroit | Michigan | 48202 | — |
| Vision Research Foundation | Grand Rapids | Michigan | 49546 | — |
| Vision Research Foundation | Royal Oak | Michigan | 48073 | — |
| Vision Research Foundation | Traverse City | Michigan | 49686 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University Health Care - Mason Eye Institute | Columbia | Missouri | 65212 | — |
| Eye Foundation of Kansas City | Kansas City | Missouri | 64108 | — |
| Mid-America Retina Consultants, PA | Kansas City | Missouri | 64111 | — |
| The Retina Institute | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Delaware Valley Retina Associates | Lawrenceville | New Jersey | 08648 | — |
| UMDNJ | Newark | New Jersey | 07103 | — |
| Ophthalmic Consultants of Long Island | Lynbrook | New York | 11563 | — |
| New York Eye and Ear Infirmary | New York | New York | 10003 | — |
| Manhattan Eye, Ear and Throat Hospital | New York | New York | 10021 | — |
| University of Rochester Eye Institute | Rochester | New York | 14642 | — |
| Retina Consultants, PLLC | Slingerlands | New York | 12159 | — |
| The Research Foundation of SUNY/Stony Brook | Stony Brook | New York | 11794 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | — |
| UNC Department of Ophthalmology | Chapel Hill | North Carolina | 27599 | — |
| Charlotte Eye Ear Nose and Throat Associates | Charlotte | North Carolina | 28210 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Wake Forest University Eye Center | Winston-Salem | North Carolina | 27157 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Retina Associates of Cleveland | Cleveland | Ohio | 44122 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Retina Associates of Cleveland | Middleburg Heights | Ohio | 44130 | — |
| Retina Associates of Cleveland | Youngstown | Ohio | 44505 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| Devers Eye Institute | Portland | Oregon | 97210 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Pennsylvania Retina Specialists, PC | Camp Hill | Pennsylvania | 17011 | — |
| Penn State M.S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Scheie Eye Institute | Philadelphia | Pennsylvania | 19104 | — |
| Wills Eye Hospital/Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| Retina Vitreous Consultants | Pittsburgh | Pennsylvania | 15213 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Palmetto Retina Center | Columbia | South Carolina | 29204 | — |
| Carolina Retina Center | Columbia | South Carolina | 29223 | — |
| Southeastern Retina Associates, PC | Knoxville | Tennessee | 37909 | — |
| University of Tennessee | Memphis | Tennessee | 38163 | — |
| Vanderbilt Eye Institute | Nashville | Tennessee | 37232 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| John Moran Eye Center | Salt Lake City | Utah | 84132 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| The Retina Group of Washington | Fairfax | Virginia | 22031 | — |
| Retina Center Northwest | Silverdale | Washington | 98383 | — |
| University of Wisconsin | Madison | Wisconsin | 53705 | — |
| The Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00345176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2015 · Synced May 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00345176 live on ClinicalTrials.gov.