DORADO-EX: Long-Term Safety Extension Study to the Phase 3 DORADO Study (Protocol DAR-311) of Darusentan in Resistant Hypertension
Public ClinicalTrials.gov record NCT00353574. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
DORADO-EX - A Dose-Blinded, Long-Term Safety Extension Study of Fixed Doses of Darusentan in Subjects With Resistant Systolic Hypertension Receiving Combination Therapy With Three or More Antihypertensive Drugs, Including a Diuretic (Protocol DAR-311-E)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a research study of a new experimental drug called darusentan. Darusentan is not currently approved by the United States (U.S.) Food and Drug Administration (FDA) for use in the U.S., which means that a doctor cannot prescribe this drug. The purpose of this study is to evaluate the long-term safety of darusentan in subjects with resistant systolic hypertension despite treatment with full doses of three or more antihypertensive medications, including a diuretic.
Study identification
- NCT ID
- NCT00353574
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 282 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2006 (Type not available)
- Primary completion
- Feb 2010 (Actual)
- Completion
- Apr 2010 (Actual)
- Last update posted
- Mar 18, 2014
2006 – 2010
United States locations
- U.S. sites
- 53
- U.S. states
- 25
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Heart Failure Center | Mobile | Alabama | 36608 | — |
| Canyon Clinical Research | Tucson | Arizona | 85712 | — |
| Chrishard Medical Group | Inglewood | California | 90301 | — |
| VA Medical Center - WLA | Los Angeles | California | 90073 | — |
| Sacramento Heart and Vascular | Sacramento | California | 95825 | — |
| Apex Research Institute | Santa Ana | California | 92705 | — |
| Complete Renal Care | Denver | Colorado | 80220 | — |
| Connecticut Clinical Research, LLC | Bridgeport | Connecticut | 06606 | — |
| MedStar Diabetes Institute at Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| White-Wilson Medical Center | Fort Walton Beach | Florida | 32569 | — |
| A.G.A. Clinical Trials | Hialeah | Florida | 33012 | — |
| Jacksonville Center for Clinical | Jacksonville | Florida | 32216 | — |
| Ricardo A. Bedoya, Cardiology | Jupiter | Florida | 33458 | — |
| International Research Association | Miami | Florida | 33156 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34231 | — |
| Tampa Bay Nephrology Associates, PL | Tampa | Florida | 33603 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Global Research Partners | Calhoun | Georgia | 30701 | — |
| Kula Research | Honolulu | Hawaii | 96816 | — |
| Chicago Heart & Vein Clinic | Elk Grove Village | Illinois | 60007 | — |
| Evanston Northwestern Healthcare | Evanston | Illinois | 60201 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Midwest Heart Foundation | Lombard | Illinois | 60148 | — |
| Medical Research Institute | Slidell | Louisiana | 70458 | — |
| Androscoggin Cardiology Associates | Auburn | Maine | 04210 | — |
| Maine Research Associate | Auburn | Maine | 04210 | — |
| Cardiovascular Consultants of Maine | Scarborough | Maine | 04074 | — |
| Clinical Associates | Reisterstown | Maryland | 21136 | — |
| Rockville Internal Medicine Group | Rockville | Maryland | 20854 | — |
| Professional Clinical Research | Benzonia | Michigan | 49616 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Professional Clinical Research | Interlochen | Michigan | 49643 | — |
| Specialty Medical Center | Pahrump | Nevada | 89048 | — |
| Physicians East, PA | Greenville | North Carolina | 27834 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| COR Clinical Research | Oklahoma City | Oklahoma | 73003 | — |
| Southwest Cardiology Associates | Oklahoma City | Oklahoma | 73109 | — |
| Castlerock Clinical Research Consultants | Tulsa | Oklahoma | 74136 | — |
| Hillsboro Cardiology, PC | Hillsboro | Oregon | 97123 | — |
| Northeast Clinical Research Centers, Inc. | Allentown | Pennsylvania | 18103 | — |
| Heritage Cardiology Associates | Camp Hill | Pennsylvania | 17011 | — |
| Brandywine Clinical Research | Downingtown | Pennsylvania | 19335 | — |
| Green and Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| RI Hospital | Providence | Rhode Island | 02903 | — |
| Neem Research Group, Inc. | Columbia | South Carolina | 29201 | — |
| Internal Medicine & Industrial Medicine | DeSoto | Texas | 75115 | — |
| T&R Clinical, P.A. | Fort Worth | Texas | 76117 | — |
| Pri-Med Care | Lewisville | Texas | 75067 | — |
| Innovative Clinical Trials | San Antonio | Texas | 78229 | — |
| Burke Internal Medicine, Inc. | Burke | Virginia | 22015 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Liberty Research Center | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00353574, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2014 · Synced Nov 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00353574 live on ClinicalTrials.gov.