Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD)
Public ClinicalTrials.gov record NCT00366145. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Prochymal® (Ex-vivo Cultured Adult Human Mesenchymal Stem Cells) Infusion for the Treatment of Patients Who Have Failed to Respond to Steroid Treatment for Acute GVHD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and gather additional safety information for Prochymal® in participants who have failed to respond to steroid treatment of Grades B-D acute GVHD.
Study identification
- NCT ID
- NCT00366145
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 260 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 6 Months to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 17, 2006 (Actual)
- Primary completion
- Dec 26, 2008 (Actual)
- Completion
- May 28, 2009 (Actual)
- Last update posted
- Feb 10, 2022
2006 – 2009
United States locations
- U.S. sites
- 47
- U.S. states
- 28
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| Arizona Cancer Center | Tucson | Arizona | 85724 | — |
| City of Hope | Duarte | California | 91010 | — |
| Univeristy of California San Francisco | San Francisco | California | 94143 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06520 | — |
| University of Miami | Miami | Florida | 33136 | — |
| All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Northwestern Center for Clinical Research | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Illinois - Chicago | Chicago | Illinois | 60612 | — |
| Indiana Blood and Bone Marrow Transplant Center | Beech Grove | Indiana | 46107 | — |
| Univeristy of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Louisiana State University | Shreveport | Louisiana | 71130 | — |
| University of Maryland/Greenbaum | Baltimore | Maryland | 21201 | — |
| Tufts-New England Medical Center | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos/Wayne State University | Detroit | Michigan | 48201 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Univeristy of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| University of Nebraska | Omaha | Nebraska | 68198 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Roswell Park | Buffalo | New York | 14263 | — |
| New York Presbyterian Hospital | New York | New York | 10021 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University/New York Presbyterian Hospital | New York | New York | 10032 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Wake Forest Univeristy School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Western Pennsylvania Cancer Institute | Pittsburgh | Pennsylvania | 15224 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Texas Cancer Center at Medical City | Dallas | Texas | 75230 | — |
| Baylor University | Dallas | Texas | 75246 | — |
| Univeristy of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Research Center | San Antonio | Texas | 78229 | — |
| Virginia Commonwealth/Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109-1024 | — |
| University of Wisconsin Madison | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00366145, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 10, 2022 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00366145 live on ClinicalTrials.gov.