CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy
Public ClinicalTrials.gov record NCT00383305. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Brain-Cooling for the Treatment of Perinatal Hypoxic-Ischemic Encephalopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a research study of head cooling. Its goal is to determine whether cooling babies' heads can reduce or prevent brain damage that may have resulted from temporarily reduced oxygen supply to the brain. In this study, half of the babies (selected at random) will have a special cooling cap with circulating water placed on their head for 72 hours to lower the temperature of their brain. The rest of the baby's body will be maintained at a defined temperature by a standard overhead radiant heater. The study protocol includes the taking and analysis of blood samples, performance of brain wave tests, imaging of the brain by ultrasound, and other tests as clinically indicated. Neurodevelopmental outcome will also be assessed at 18 months of age.
Study identification
- NCT ID
- NCT00383305
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 235 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 1 Hour to 6 Hours
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1999 (Type not available)
- Primary completion
- Not listed
- Completion
- Sep 2003 (Type not available)
- Last update posted
- Oct 3, 2006
1999 – 2003
United States locations
- U.S. sites
- 19
- U.S. states
- 12
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Children's Hospital and Research Center at Oakland | Oakland | California | 94609 | — |
| University of California San Diego Medical Center (Hillcrest) | San Diego | California | 92103 | — |
| University of California San Francisco Children's Hospital | San Francisco | California | 94110 | — |
| Children's Hospital of Denver | Denver | Colorado | 80262 | — |
| Children's Memorial Hospital / Prentice Women's Hospital | Chicago | Illinois | 60611 | — |
| University of Illinois at Chicago Medical Center | Chicago | Illinois | 60612 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| University of Michigan Medical Center - Mott Children's Hospital | Ann Arbor | Michigan | 48109 | — |
| Children's Hospital and Clinics of Minneapolis | Minneapolis | Minnesota | 55404 | — |
| Schneider Children's Hospital | New Hyde Park | New York | 11040 | — |
| Children's Hospital of new York - Presbyterian (Columbia University) | New York | New York | 10032 | — |
| Golisano Children's Hospital at Strong | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Children's Hospital of Oklahoma | Oklahoma City | Oklahoma | 73190 | — |
| AI Dupont Children's Hospital at Thomas Jefferson University Medical Center | Philadelphia | Pennsylvania | 19107 | — |
| Magee Women's Hospital / Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00383305, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 3, 2006 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00383305 live on ClinicalTrials.gov.