Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy
Public ClinicalTrials.gov record NCT00445003. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Intravitreal Ranibizumab or Triamcinolone Acetonide as Adjunctive Treatment to Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to find out if treatment with an intravitreal injection of triamcinolone or an intravitreal injection of ranibizumab can prevent loss of vision caused by panretinal photocoagulation treatment. At the present time, it is not known whether intravitreal steroid or anti-vascular endothelial growth factor (anti-VEGF) injections are beneficial in preventing vision loss after panretinal photocoagulation (PRP) treatment. It is possible that one or both of the types of injections will prevent vision loss after PRP treatment. However, it is not known whether the benefits of the injections will outweigh the risks. It is possible that because of side effects, the injections may not be as good as laser alone in treating the diabetic retinopathy.
Study identification
- NCT ID
- NCT00445003
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 333 participants
Conditions and interventions
Interventions
- Ranibizumab Drug
- Triamcinolone Acetonide Drug
- Sham injection Behavioral
- Focal/grid laser Procedure
Drug · Behavioral · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2007 (Type not available)
- Primary completion
- Oct 2009 (Actual)
- Completion
- Jul 2010 (Actual)
- Last update posted
- Aug 26, 2016
2007 – 2010
United States locations
- U.S. sites
- 56
- U.S. states
- 25
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sall Research Medical Center | Artesia | California | 90701 | — |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| Loma Linda University Health Care, Dept. of Ophthalmology | Loma Linda | California | 92354 | — |
| Southern California Desert Retina Consultants, MC | Palm Springs | California | 92262 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| Eldorado Retina Associates, P.C. | Louisville | Colorado | 80027 | — |
| Retina Vitreous Consultants | Fort Lauderdale | Florida | 33334 | — |
| Retina Consultants of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Central Florida Retina Institute | Lakeland | Florida | 33805 | — |
| Southeast Retina Center, P.C. | Augusta | Georgia | 30909 | — |
| University of Illinois at Chicago Medical Center | Chicago | Illinois | 60612 | — |
| Illinois Retina Associates | Joliet | Illinois | 60435 | — |
| Raj K. Maturi, M.D., P.C. | Indianapolis | Indiana | 46280 | — |
| John-Kenyon American Eye Institute | New Albany | Indiana | 47150 | — |
| Medical Associates Clinic, P.C. | Dubuque | Iowa | 52002 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Maine Vitreoretinal Consultants | Bangor | Maine | 04401 | — |
| Elman Retina Group, P.A. | Baltimore | Maryland | 21237 | — |
| Wilmer Ophthalmological Institute at Johns Hopkins | Baltimore | Maryland | 21287-9277 | — |
| Retina Consultants of Delmarva, P.A. | Salisbury | Maryland | 21801 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Retina Center, PA | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Eyesight Ophthalmic Services, PA | Portsmouth | New Hampshire | 03801 | — |
| The New York Eye and Ear Infirmary/Faculty Eye Practice | New York | New York | 10003 | — |
| Retina-Vitreous Surgeons of Central New York, PC | Syracuse | New York | 13224 | — |
| University of North Carolina, Dept of Ophthalmology | Chapel Hill | North Carolina | 27599-7040 | — |
| Charlotte Eye, Ear, Nose and Throat Assoc., PA | Charlotte | North Carolina | 28210 | — |
| Horizon Eye Care, PA | Charlotte | North Carolina | 28211 | — |
| Wake Forest University Eye Center | Winston-Salem | North Carolina | 27157 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| OSU Eye Physicians and Surgeons, LLC. | Dublin | Ohio | 43017 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Casey Eye Institute | Portland | Oregon | 97239 | — |
| Penn State College of Medicine | Hershey | Pennsylvania | 17033 | — |
| University of Pennsylvania Scheie Eye Institute | Philadelphia | Pennsylvania | 19104 | — |
| Retina Consultants | Providence | Rhode Island | 02903 | — |
| Palmetto Retina Center | Columbia | South Carolina | 29169 | — |
| Carolina Retina Center | Columbia | South Carolina | 29223 | — |
| Southeastern Retina Associates, PC | Kingsport | Tennessee | 37660 | — |
| Southeastern Retina Associates, P.C. | Knoxville | Tennessee | 37909 | — |
| West Texas Retina Consultants P.A. | Abilene | Texas | 79605 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Retina and Vitreous of Texas | Houston | Texas | 77025 | — |
| Vitreoretinal Consultants | Houston | Texas | 77030 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| Virginia Retina Center | Leesburg | Virginia | 20176 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| University of Wisconsin-Madison, Dept of Ophthalmology/Retina Service | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00445003, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 26, 2016 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00445003 live on ClinicalTrials.gov.