A Study of Bevacizumab (Avastin) in Combination With Rituximab (MabThera) and CHOP (Cyclophosphamide, Hydroxydaunorubicin [Doxorubicin], Oncovin [Vincristine], Prednisone) Chemotherapy in Patients With Diffuse Large B-cell Lymphoma
Public ClinicalTrials.gov record NCT00486759. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Trial Comparing the Efficacy of Bevacizumab in Combination With Rituximab and CHOP (R-CHOP + Bevacizumab) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients With CD20-positive Diffuse Large B-cell Lymphoma (DLBCL)
Study identification
- NCT ID
- NCT00486759
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 787 participants
Conditions and interventions
Conditions
Interventions
- Bevacizumab Drug
- CHOP Drug
- Placebo Drug
- Rituximab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 25, 2007
- Primary completion
- Nov 29, 2011
- Completion
- Nov 29, 2011
- Last update posted
- Jul 24, 2017
2007 – 2011
United States locations
- U.S. sites
- 17
- U.S. states
- 11
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of California - San Diego; Cancer Center & Dept of Medicine | La Jolla | California | 92093 | — |
| Kenmar Research Inst. | Whittier | California | 90603 | — |
| University of Colorado Cancer Center Department of Hematology | Aurora | Colorado | 80045 | — |
| Uni Medical Center; Division Of Hemotology/Oncology | Jacksonville | Florida | 32207 | — |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | — |
| Northwest Georgia Oncology Centers | Marietta | Georgia | 30060 | — |
| University of Kansas Medical Center; Department of Hematology | Kansas City | Kansas | 66160 | — |
| St. Joseph Mercy Hospital; Department of Oncology | Ann Arbor | Michigan | 48106 | — |
| Northeast Oncology Associates | Concord | North Carolina | 28025 | — |
| Forsyth Regional Cancer Center; Piedmont Hematology/Oncology Associates | Winston-Salem | North Carolina | 27103 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Charleston Cancer Center | Charleston | South Carolina | 29406 | — |
| Uni of Texas Southwestern Medical Center | Dallas | Texas | 75390-9063 | — |
| Cancer Therapy & Research Center | San Antonio | Texas | 78229 | — |
| Northwest Medical Specialties B | Federal Way | Washington | 98003 | — |
| Rainier Physicians | Puyallup | Washington | 98372 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 249 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00486759, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 24, 2017 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00486759 live on ClinicalTrials.gov.