ClinicalTrials.gov record
ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D
ClinicalTrials.gov ID: NCT00490139
Public ClinicalTrials.gov record NCT00490139. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomised, Multi-centre, Open-label, Phase III Study of Adjuvant Lapatinib, Trastuzumab, Their Sequence and Their Combination in Patients With HER2/ErbB2 Positive Primary Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a four-arm (parallel group) randomized, open-label, multicenter Phase 3 study to investigate the use of a combination of Lapatinib and Trastuzumab, a sequence of Trastuzumab followed by Lapatinib, and Lapatinib alone, compared to Trastuzumab alone in the adjuvant treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive early breast cancer.
Study identification
- NCT ID
- NCT00490139
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 8,381 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 15, 2007
- Primary completion
- Dec 5, 2013
- Completion
- Jun 30, 2021
- Last update posted
- Mar 20, 2025
2007 – 2021
United States locations
- U.S. sites
- 260
- U.S. states
- 48
- U.S. cities
- 224
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Mobile | Alabama | 36608 | — |
| Novartis Investigative Site | Anchorage | Alaska | 99508 | — |
| Novartis Investigative Site | Tucson | Arizona | 85715 | — |
| Novartis Investigative Site | Jonesboro | Arkansas | 72401 | — |
| Novartis Investigative Site | Duarte | California | 91010 | — |
| Novartis Investigative Site | Fairfield | California | 94533 | — |
| Novartis Investigative Site | La Jolla | California | 92093-0987 | — |
| Novartis Investigative Site | La Jolla | California | 92093 | — |
| Novartis Investigative Site | Loma Linda | California | 92534 | — |
| Novartis Investigative Site | Martinez | California | 94553-3156 | — |
| Novartis Investigative Site | Marysville | California | 95901 | — |
| Novartis Investigative Site | Mountain View | California | 94040 | — |
| Novartis Investigative Site | Oakland | California | 94609 | — |
| Novartis Investigative Site | Pleasanton | California | 94588 | — |
| Novartis Investigative Site | Sacramento | California | 95817 | — |
| Novartis Investigative Site | San Francisco | California | 94110 | — |
| Novartis Investigative Site | Aurora | Colorado | 80012 | — |
| Novartis Investigative Site | Boulder | Colorado | 80301 | — |
| Novartis Investigative Site | Colorado Springs | Colorado | 80907 | — |
| Novartis Investigative Site | Denver | Colorado | 80210 | — |
| Novartis Investigative Site | Denver | Colorado | 80218 | — |
| Novartis Investigative Site | Denver | Colorado | 80220 | — |
| Novartis Investigative Site | Fort Collins | Colorado | 80524 | — |
| Novartis Investigative Site | Fort Collins | Colorado | 80528 | — |
| Novartis Investigative Site | Thornton | Colorado | 80229 | — |
| Novartis Investigative Site | Wheat Ridge | Colorado | 80033 | — |
| Novartis Investigative Site | Hartford | Connecticut | 06105 | — |
| Novartis Investigative Site | New Haven | Connecticut | 06520 | — |
| Novartis Investigative Site | Dover | Delaware | 19901 | — |
| Novartis Investigative Site | Washington D.C. | District of Columbia | 20007 | — |
| Novartis Investigative Site | Washington D.C. | District of Columbia | 20307 | — |
| Novartis Investigative Site | Boca Raton | Florida | 33486 | — |
| Novartis Investigative Site | Fort Lauderdale | Florida | 33308 | — |
| Novartis Investigative Site | Fort Myers | Florida | 33916 | — |
| Novartis Investigative Site | Hollywood | Florida | 33021 | — |
| Novartis Investigative Site | Jacksonville | Florida | 32207 | — |
| Novartis Investigative Site | Jacksonville | Florida | 32224 | — |
| Novartis Investigative Site | Lakeland | Florida | 33805 | — |
| Novartis Investigative Site | Ocala | Florida | 34474 | — |
| Novartis Investigative Site | Orlando | Florida | 32803 | — |
| Novartis Investigative Site | Orlando | Florida | 32806 | — |
| Novartis Investigative Site | Weston | Florida | 33331 | — |
| Novartis Investigative Site | Athens | Georgia | 30607 | — |
| Novartis Investigative Site | Atlanta | Georgia | 30309 | — |
| Novartis Investigative Site | Atlanta | Georgia | 30342 | — |
| Novartis Investigative Site | Augusta | Georgia | 30912 | — |
| Novartis Investigative Site | Columbus | Georgia | 31904 | — |
| Novartis Investigative Site | Decatur | Georgia | 30033 | — |
| Novartis Investigative Site | Savannah | Georgia | 31405 | — |
| Novartis Investigative Site | Honolulu | Hawaii | 96813 | — |
| Novartis Investigative Site | Honolulu | Hawaii | 96859 | — |
| Novartis Investigative Site | Lihue | Hawaii | 96766 | — |
| Novartis Investigative Site | Boise | Idaho | 83706 | — |
| Novartis Investigative Site | Boise | Idaho | 83712 | — |
| Novartis Investigative Site | Chicago | Illinois | 60611 | — |
| Novartis Investigative Site | Evanston | Illinois | 60201 | — |
| Novartis Investigative Site | Harvey | Illinois | 60426 | — |
| Novartis Investigative Site | Kankakee | Illinois | 60901 | — |
| Novartis Investigative Site | Maywood | Illinois | 60153 | — |
| Novartis Investigative Site | Mount Vernon | Illinois | 62864 | — |
| Novartis Investigative Site | Oak Lawn | Illinois | 60453-2699 | — |
| Novartis Investigative Site | Ottawa | Illinois | 61350 | — |
| Novartis Investigative Site | Pekin | Illinois | 61554 | — |
| Novartis Investigative Site | Peoria | Illinois | 61615 | — |
| Novartis Investigative Site | Peru | Illinois | 61354 | — |
| Novartis Investigative Site | Princeton | Illinois | 61356 | — |
| Novartis Investigative Site | Rockford | Illinois | 61104 | — |
| Novartis Investigative Site | Rockford | Illinois | 61114 | — |
| Novartis Investigative Site | Skokie | Illinois | 60077 | — |
| Novartis Investigative Site | Springfield | Illinois | 62781-0001 | — |
| Novartis Investigative Site | Urbana | Illinois | 61801 | — |
| Novartis Investigative Site | Beech Grove | Indiana | 46107 | — |
| Novartis Investigative Site | Fort Wayne | Indiana | 46815 | — |
| Novartis Investigative Site | Indianapolis | Indiana | 46202 | — |
| Novartis Investigative Site | Kokomo | Indiana | 46904 | — |
| Novartis Investigative Site | Mishawaka | Indiana | 46545 | — |
| Novartis Investigative Site | Muncie | Indiana | 47303 | — |
| Novartis Investigative Site | South Bend | Indiana | 46601 | — |
| Novartis Investigative Site | South Bend | Indiana | 46617 | — |
| Novartis Investigative Site | Ames | Iowa | 50010 | — |
| Novartis Investigative Site | Bettendorf | Iowa | 52722 | — |
| Novartis Investigative Site | Cedar Rapids | Iowa | 52402 | — |
| Novartis Investigative Site | Des Moines | Iowa | 50309 | — |
| Novartis Investigative Site | Des Moines | Iowa | 50314 | — |
| Novartis Investigative Site | Mason City | Iowa | — | — |
| Novartis Investigative Site | Sioux City | Iowa | 51101-1733 | — |
| Novartis Investigative Site | Waterloo | Iowa | 50702 | — |
| Novartis Investigative Site | Chanute | Kansas | 66720 | — |
| Novartis Investigative Site | El Dorado | Kansas | 67042 | — |
| Novartis Investigative Site | Independence | Kansas | 67301 | — |
| Novartis Investigative Site | Lawrence | Kansas | 66044 | — |
| Novartis Investigative Site | Prairie Village | Kansas | 66208 | — |
| Novartis Investigative Site | Pratt | Kansas | 67124 | — |
| Novartis Investigative Site | Topeka | Kansas | 66604 | — |
| Novartis Investigative Site | Topeka | Kansas | 66606 | — |
| Novartis Investigative Site | Wichita | Kansas | 67214 | — |
| Novartis Investigative Site | Louisville | Kentucky | 40292 | — |
| Novartis Investigative Site | Baton Rouge | Louisiana | 70809 | — |
| Novartis Investigative Site | New Orleans | Louisiana | 70112 | — |
| Novartis Investigative Site | New Orleans | Louisiana | 70121 | — |
| Novartis Investigative Site | Portland | Maine | 04101 | — |
| Novartis Investigative Site | Scarborough | Maine | 04074 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21201 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21287-8936 | — |
| Novartis Investigative Site | Bethesda | Maryland | 20889-5600 | — |
| Novartis Investigative Site | Frederick | Maryland | 21701 | — |
| Novartis Investigative Site | Silver Spring | Maryland | 20910 | — |
| Novartis Investigative Site | Towson | Maryland | 21204 | — |
| Novartis Investigative Site | Westminster | Maryland | 21157 | — |
| Novartis Investigative Site | Boston | Massachusetts | 02135 | — |
| Novartis Investigative Site | Hyannis | Massachusetts | 02601 | — |
| Novartis Investigative Site | Peabody | Massachusetts | 01960 | — |
| Novartis Investigative Site | Adrian | Michigan | 49221 | — |
| Novartis Investigative Site | Ann Arbor | Michigan | 48106-0995 | — |
| Novartis Investigative Site | Dearborn | Michigan | 48123 | — |
| Novartis Investigative Site | Detroit | Michigan | 48202 | — |
| Novartis Investigative Site | Flint | Michigan | 48532 | — |
| Novartis Investigative Site | Iron Mountain | Michigan | 49801 | — |
| Novartis Investigative Site | Kalamazoo | Michigan | 49007 | — |
| Novartis Investigative Site | Pontiac | Michigan | 48341-2985 | — |
| Novartis Investigative Site | Saginaw | Michigan | 48601 | — |
| Novartis Investigative Site | Saint Joseph | Michigan | 49085 | — |
| Novartis Investigative Site | Southfield | Michigan | 48075 | — |
| Novartis Investigative Site | Albert Lea | Minnesota | 56007 | — |
| Novartis Investigative Site | Duluth | Minnesota | 55805 | — |
| Novartis Investigative Site | Edina | Minnesota | 55435 | — |
| Novartis Investigative Site | Mankato | Minnesota | 56002 | — |
| Novartis Investigative Site | Maplewood | Minnesota | 55109 | — |
| Novartis Investigative Site | Minneapolis | Minnesota | 55407-3799 | — |
| Novartis Investigative Site | Minneapolis | Minnesota | 55415 | — |
| Novartis Investigative Site | Saint Cloud | Minnesota | 56303 | — |
| Novartis Investigative Site | Saint Louis Park | Minnesota | 55416 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55101 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55102 | — |
| Novartis Investigative Site | Shakopee | Minnesota | 55379 | — |
| Novartis Investigative Site | Waconia | Minnesota | 55387 | — |
| Novartis Investigative Site | Willmar | Minnesota | 56201 | — |
| Novartis Investigative Site | Pascagoula | Mississippi | 39581 | — |
| Novartis Investigative Site | Kansas City | Missouri | 64131 | — |
| Novartis Investigative Site | Springfield | Missouri | 65807 | — |
| Novartis Investigative Site | St Louis | Missouri | 63110 | — |
| Novartis Investigative Site | Billings | Montana | 59101 | — |
| Novartis Investigative Site | Bozeman | Montana | 59715 | — |
| Novartis Investigative Site | Great Falls | Montana | 59405 | — |
| Novartis Investigative Site | Grand Island | Nebraska | 68803 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68510 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68106 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68114 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68122 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68124 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68131 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68198 | — |
| Novartis Investigative Site | Las Vegas | Nevada | 89169 | — |
| Novartis Investigative Site | Concord | New Hampshire | 03301 | — |
| Novartis Investigative Site | Hooksett | New Hampshire | 03106 | — |
| Novartis Investigative Site | Laconia | New Hampshire | 03246 | — |
| Novartis Investigative Site | Lebanon | New Hampshire | 03756 | — |
| Novartis Investigative Site | Hackensack | New Jersey | 07601 | — |
| Novartis Investigative Site | Livingston | New Jersey | 07039 | — |
| Novartis Investigative Site | New Brunswick | New Jersey | 08901 | — |
| Novartis Investigative Site | Princeton | New Jersey | 24740 | — |
| Novartis Investigative Site | Somerville | New Jersey | 08876 | — |
| Novartis Investigative Site | Sparta | New Jersey | 07871 | — |
| Novartis Investigative Site | Vineland | New Jersey | 08360 | — |
| Novartis Investigative Site | Albuquerque | New Mexico | 87106 | — |
| Novartis Investigative Site | Albuquerque | New Mexico | 87110 | — |
| Novartis Investigative Site | Las Cruces | New Mexico | 88011 | — |
| Novartis Investigative Site | Buffalo | New York | 14263 | — |
| Novartis Investigative Site | Cooperstown | New York | 13326 | — |
| Novartis Investigative Site | East Syracuse | New York | 13057 | — |
| Novartis Investigative Site | Manhasset | New York | 11030 | — |
| Novartis Investigative Site | New York | New York | 10003 | — |
| Novartis Investigative Site | New York | New York | 10011 | — |
| Novartis Investigative Site | New York | New York | 10016 | — |
| Novartis Investigative Site | New York | New York | 10032 | — |
| Novartis Investigative Site | Rochester | New York | 14642 | — |
| Novartis Investigative Site | The Bronx | New York | 10461 | — |
| Novartis Investigative Site | The Bronx | New York | 10467-2490 | — |
| Novartis Investigative Site | Chapel Hill | North Carolina | 27599 | — |
| Novartis Investigative Site | Hendersonville | North Carolina | 28791 | — |
| Novartis Investigative Site | Kinston | North Carolina | 28501 | — |
| Novartis Investigative Site | Raleigh | North Carolina | 27607 | — |
| Novartis Investigative Site | Washington | North Carolina | 27889 | — |
| Novartis Investigative Site | Winston-Salem | North Carolina | 27157 | — |
| Novartis Investigative Site | Bismarck | North Dakota | 58501 | — |
| Novartis Investigative Site | Fargo | North Dakota | 58122 | — |
| Novartis Investigative Site | Minot | North Dakota | 58701 | — |
| Novartis Investigative Site | Bowling Green | Ohio | 43402 | — |
| Novartis Investigative Site | Canton | Ohio | 44710 | — |
| Novartis Investigative Site | Chillicothe | Ohio | 54601 | — |
| Novartis Investigative Site | Cincinnati | Ohio | 45242 | — |
| Novartis Investigative Site | Clyde | Ohio | 43410 | — |
| Novartis Investigative Site | Columbus | Ohio | 43210 | — |
| Novartis Investigative Site | Columbus | Ohio | 43214 | — |
| Novartis Investigative Site | Columbus | Ohio | 43215 | — |
| Novartis Investigative Site | Columbus | Ohio | 43222 | — |
| Novartis Investigative Site | Dayton | Ohio | 45415 | — |
| Novartis Investigative Site | Franklin | Ohio | 45005-1066 | — |
| Novartis Investigative Site | Greenville | Ohio | 45331 | — |
| Novartis Investigative Site | Kettering | Ohio | 45429 | — |
| Novartis Investigative Site | Maumee | Ohio | 43623 | — |
| Novartis Investigative Site | Sandusky | Ohio | 44870 | — |
| Novartis Investigative Site | Sylvania | Ohio | 43560 | — |
| Novartis Investigative Site | Toledo | Ohio | 43623 | — |
| Novartis Investigative Site | Oklahoma City | Oklahoma | 73120 | — |
| Novartis Investigative Site | Tulsa | Oklahoma | 74136 | — |
| Novartis Investigative Site | Eugene | Oregon | 97401 | — |
| Novartis Investigative Site | Portland | Oregon | 97210 | — |
| Novartis Investigative Site | Abington | Pennsylvania | 19001-3788 | — |
| Novartis Investigative Site | Bethlehem | Pennsylvania | 18015 | — |
| Novartis Investigative Site | Hershey | Pennsylvania | 17033 | — |
| Novartis Investigative Site | Kingston | Pennsylvania | 18704 | — |
| Novartis Investigative Site | Nashville | Pennsylvania | 37204 | — |
| Novartis Investigative Site | Philadelphia | Pennsylvania | 19111 | — |
| Novartis Investigative Site | Pottstown | Pennsylvania | 19464 | — |
| Novartis Investigative Site | Sayre | Pennsylvania | 18840 | — |
| Novartis Investigative Site | West Reading | Pennsylvania | 19611 | — |
| Novartis Investigative Site | Charleston | South Carolina | 29406 | — |
| Novartis Investigative Site | Greenville | South Carolina | 29605 | — |
| Novartis Investigative Site | Rapid City | South Dakota | 57701 | — |
| Novartis Investigative Site | Chattanooga | Tennessee | 37403 | — |
| Novartis Investigative Site | Chattanooga | Tennessee | 37404 | — |
| Novartis Investigative Site | Jackson | Tennessee | 38301 | — |
| Novartis Investigative Site | Knoxville | Tennessee | 37920 | — |
| Novartis Investigative Site | Memphis | Tennessee | 38120 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37203 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37208 | — |
| Novartis Investigative Site | Nashville | Tennessee | 37232 | — |
| Novartis Investigative Site | Beaumont | Texas | 77702-1449 | — |
| Novartis Investigative Site | Bedford | Texas | 76022 | — |
| Novartis Investigative Site | Fort Sam Houston | Texas | 78234 | — |
| Novartis Investigative Site | Fort Worth | Texas | 76104 | — |
| Novartis Investigative Site | Houston | Texas | 77030 | — |
| Novartis Investigative Site | Lackland Air Force Base | Texas | 78236 | — |
| Novartis Investigative Site | Longview | Texas | 75601 | — |
| Novartis Investigative Site | McAllen | Texas | 78503-1298 | — |
| Novartis Investigative Site | Mesquite | Texas | 75150 | — |
| Novartis Investigative Site | Midland | Texas | 79701 | — |
| Novartis Investigative Site | San Antonio | Texas | 78209 | — |
| Novartis Investigative Site | San Antonio | Texas | 78229 | — |
| Novartis Investigative Site | Tyler | Texas | 75702 | — |
| Novartis Investigative Site | Salt Lake City | Utah | 84112 | — |
| Novartis Investigative Site | Hampton | Virginia | 23666 | — |
| Novartis Investigative Site | Richmond | Virginia | 23230 | — |
| Novartis Investigative Site | Roanoke | Virginia | 24014 | — |
| Novartis Investigative Site | Bellingham | Washington | 98225 | — |
| Novartis Investigative Site | Seattle | Washington | 98122 | — |
| Novartis Investigative Site | Seattle | Washington | 98133 | — |
| Novartis Investigative Site | Spokane | Washington | 99218 | — |
| Novartis Investigative Site | Tacoma | Washington | 98405 | — |
| Novartis Investigative Site | Charleston | West Virginia | 25304 | — |
| Novartis Investigative Site | Huntington | West Virginia | 25701 | — |
| Novartis Investigative Site | Appleton | Wisconsin | 53715 | — |
| Novartis Investigative Site | Chippewa Falls | Wisconsin | 54729 | — |
| Novartis Investigative Site | Eau Claire | Wisconsin | 54702 | — |
| Novartis Investigative Site | Green Bay | Wisconsin | 54301 | — |
| Novartis Investigative Site | La Crosse | Wisconsin | 54601 | — |
| Novartis Investigative Site | Madison | Wisconsin | 53717 | — |
| Novartis Investigative Site | Oshkosh | Wisconsin | 54904 | — |
| Novartis Investigative Site | Sturgeon Bay | Wisconsin | 54235 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 664 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00490139, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2025 · Synced Sep 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00490139 live on ClinicalTrials.gov.