Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
Public ClinicalTrials.gov record NCT00626990. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma. PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma.
Study identification
- NCT ID
- NCT00626990
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 751 participants
Conditions and interventions
Conditions
Interventions
- temozolomide Drug
- DNA methylation analysis Genetic
- laboratory biomarker analysis Other
- adjuvant therapy Procedure
- quality-of-life assessment Procedure
- radiation therapy Radiation
Drug · Genetic · Other + 2 more
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2007 (Actual)
- Primary completion
- Sep 5, 2018 (Actual)
- Completion
- Dec 2029 (Estimated)
- Last update posted
- Sep 11, 2023
2007 – 2029
United States locations
- U.S. sites
- 72
- U.S. states
- 25
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Services Foundation | Phoenix | Arizona | — | — |
| Cedars-Sinai Medical Center | Los Angeles | California | — | — |
| UCSF University of California San Francisco Medical Center-Mount Zion | San Francisco | California | — | — |
| University of Florida | Gainesville | Florida | — | — |
| Mayo Clinic in Florida | Jacksonville | Florida | — | — |
| Florida Hospital | Orlando | Florida | — | — |
| Emory University | Atlanta | Georgia | — | — |
| Memorial Health University Medical Center | Savannah | Georgia | — | — |
| Northwestern University | Chicago | Illinois | — | — |
| Loyola University Medical Center | Maywood | Illinois | — | — |
| Oncology Associates PC | Fort Wayne | Indiana | — | — |
| Parkview Hospital | Fort Wayne | Indiana | — | — |
| Saint Vincent Oncology Center | Indianapolis | Indiana | — | — |
| McFarland Clinic | Ames | Iowa | 50010 | — |
| June E. Nylen Cancer Center | Sioux City | Iowa | — | — |
| Via Christi Regional Medical Center | Wichita | Kansas | — | — |
| Wesley Medical Center | Wichita | Kansas | — | — |
| Maine Medical Center | Scarborough | Maine | — | — |
| Boston Medical Center | Boston | Massachusetts | — | — |
| Brigham and Women's Hospital | Boston | Massachusetts | — | — |
| Massachussets General Hospital Cancer Center | Boston | Massachusetts | — | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | — | — |
| Henry Ford Hospital | Detroit | Michigan | — | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | — | — |
| St John's Mercy Medical Center | St Louis | Missouri | — | — |
| Methodist Estabrook Cancer Center | Omaha | Nebraska | — | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | — | — |
| State University of New York Upstate Medical University | New York | New York | — | — |
| Highland Hospital | Rochester | New York | — | — |
| University of Rochester - James P. Wilmot Cancer Center | Rochester | New York | — | — |
| Carolinas Medical Center | Charlotte | North Carolina | — | — |
| Akron City Hospital - Summa Health System | Akron | Ohio | — | — |
| Summa Barberton Hospital | Barberton | Ohio | — | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | — | — |
| MetroHealth Medical Center | Cleveland | Ohio | — | — |
| Western Reserve University | Cleveland | Ohio | — | — |
| Ohio State University Medical Center | Columbus | Ohio | — | — |
| Southwest General Health Center Ireland Cancer Center | Middleburg Heights | Ohio | — | — |
| UHHS-Chagrin Highlands Medical Center | Orange | Ohio | — | — |
| Cancer Care Center, Incorporated | Salem | Ohio | — | — |
| UHHS - Westlake Medical Center | Westlake | Ohio | — | — |
| Cancer Treatment Center | Wooster | Ohio | — | — |
| Abington Memorial Hospital | Abington | Pennsylvania | — | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | — | — |
| UPMC - Heritage Valley Health System - The Medical Center | Beaver | Pennsylvania | — | — |
| Penn State M.S. Hershey Medical Center | Hershey | Pennsylvania | — | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | — | — |
| Reading Hospital and Medical Center | West Reading | Pennsylvania | — | — |
| Medical University of South Carolina | Charleston | South Carolina | — | — |
| Cancer Centers of the Carolinas - Eastside | Greenville | South Carolina | — | — |
| Cancer Centers of the Carolinas - Faris Road | Greenville | South Carolina | — | — |
| Cancer Centers of the Carolinas - Greer Radiation Oncology | Greer | South Carolina | — | — |
| Cancer Centers of the Carolinas - Seneca | Seneca | South Carolina | — | — |
| Spartanburg Regional Medical Center | Spartanburg | South Carolina | — | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | — | — |
| University of Texas Medical Branch | Galveston | Texas | — | — |
| Md Anderson Cancer Center | Houston | Texas | — | — |
| Methodist Hospital | Houston | Texas | — | — |
| Intermountain Medical Center | Murray | Utah | — | — |
| Utah Valley Regional Medical Center | Provo | Utah | — | — |
| LDS Hospital | Salt Lake City | Utah | — | — |
| University Of Utah - Huntsman Cancer Institute | Salt Lake City | Utah | — | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | — | — |
| Virginia Commonwealth University | Richmond | Virginia | — | — |
| Swedish Cancer Institute | Seattle | Washington | — | — |
| Virginia Mason CCOP | Seattle | Washington | — | — |
| Saint Mary's Hospital | Green Bay | Wisconsin | — | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | — | — |
| Gundersen Lutheran | La Crosse | Wisconsin | — | — |
| University Of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | — | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | — | — |
| Waukesha Memorial Hospital | Waukesha | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 60 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00626990, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 11, 2023 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00626990 live on ClinicalTrials.gov.