CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I

ClinicalTrials.gov ID: NCT00661453

Public ClinicalTrials.gov record NCT00661453. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:14 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase I/II Trial of Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy Type I (CARNI-VAL Type I)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a multi-center trial to test safety and evaluate early treatment intervention with valproic acid and carnitine in moderating SMA symptoms of Type I infants.

Study identification

NCT ID: NCT00661453
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: University of Utah; Other
Enrollment: 40 participants

Conditions and interventions

Conditions

Spinal Muscular Atrophy Type I

Interventions

Valproic Acid and Levocarnitine Drug

Drug

Eligibility (public fields only)

Age range: 2 Weeks to 12 Months
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 2008 (Type not available)
Primary completion: May 2012 (Actual)
Completion: Jun 2012 (Actual)
Last update posted: Jun 15, 2015

2008 – 2012

United States locations

U.S. sites: 6
U.S. states: 6
U.S. cities: 6

Facility	City	State	ZIP	Site status
Johns Hopkins University	Baltimore	Maryland	21287	—
Children's Hospital of Michigan	Detroit	Michigan	48201	—
Duke University Medical Center	Durham	North Carolina	27710	—
Ohio State University Medical Center, Dept. of Neurology	Columbus	Ohio	43210	—
University of Utah/Primary Children's Medical Center	Salt Lake City	Utah	84132	—
University of Wisconsin Children's Hospital	Madison	Wisconsin	53792-9988	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00661453, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 15, 2015 · Synced Oct 21, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00661453 live on ClinicalTrials.gov.

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