Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Public ClinicalTrials.gov record NCT00784134. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overall objective of this Phase III clinical trial is to obtain information from a population of 500 ICH subjects with intraventricular hemorrhage (IVH), representative of current clinical practice and national demographics of ICH regarding the benefit (or lack thereof) of IVH clot removal on subject function as measured by modified Rankin Scale (mRS). This application requests funding for five years to initiate a Phase III randomized clinical trial (RCT) testing the benefit of clot removal for intraventricular hemorrhage. The investigators propose to compare extraventricular drainage (EVD) use plus recombinant tissue plasminogen activator (rt-PA; Alteplase; Genentech, Inc., San Francisco, CA) with EVD+ placebo in the management and treatment of subjects with small intracerebral hemorrhage (ICH) and large intraventricular hemorrhage (IVH defined as ICH \< 30 cc and obstruction of the 3rd or 4th ventricles by intraventricular blood clot).
Study identification
- NCT ID
- NCT00784134
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2009 (Type not available)
- Primary completion
- Jul 2015 (Actual)
- Completion
- Jan 2016 (Actual)
- Last update posted
- Dec 5, 2018
2009 – 2016
United States locations
- U.S. sites
- 52
- U.S. states
- 24
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mayo Clinic, Arizona | Phoenix | Arizona | 85054 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of Southern California - Keck School of Medicine | Los Angeles | California | 90089 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| Stanford University | Palo Alto | California | 94034 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| Yale University | New Haven | Connecticut | 06520-8018 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | — |
| Mayo Clinic, Jacksonville | Jacksonville | Florida | 32224 | — |
| Intercoastal Medical Center | Sarasota | Florida | 34232 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Rush University | Chicago | Illinois | 60612 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Ruan Neurology Clinical and Research Center | Des Moines | Iowa | 50314 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Kansas University Medical Center | Kansas City | Kansas | 66160 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University | Baltimore | Maryland | 21230 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| St. Luke's Brain and Stroke Institute | Kansas City | Missouri | 64111 | — |
| Springfield Neurological and Spine Institute | Springfield | Missouri | 65804 | — |
| St. Louis University | St Louis | Missouri | 63104 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| New Jersey Neuroscience Institute at JFK | Edison | New Jersey | 08818 | — |
| University of Buffalo | Buffalo | New York | 14203 | — |
| Northshore University Hospital Long Island | Manhasset | New York | 11030 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University | New York | New York | 10032 | — |
| SUNY Upstate Medical Center | Syracuse | New York | 13210 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Case-Western Reserve University Hospital | Cleveland | Ohio | 44106 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Maine Medical Center | Portland | Oregon | 04102 | — |
| Providence Stroke Center | Portland | Oregon | 97225 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt | Nashville | Tennessee | 37232 | — |
| University of Texas, Southwestern, Dallas | Dallas | Texas | 75390 | — |
| University of Texas, Houston | Houston | Texas | 77030 | — |
| University of Texas, San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 29 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00784134, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 5, 2018 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00784134 live on ClinicalTrials.gov.