BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Public ClinicalTrials.gov record NCT00828009. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Study of L-BLP25 and Bevacizumab in Unresectable Stage IIIA and IIIB Non-Squamous Non-Small Cell Lung Cancer After Definitive Chemoradiation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Vaccines may help the body build an effective immune response to kill tumor cells. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving vaccine therapy together with bevacizumab after chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects of giving BLP25 liposome vaccine together with bevacizumab after chemotherapy and radiation therapy in treating patients with newly diagnosed stage IIIA or stage IIIB non-small cell lung cancer that cannot be removed by surgery.
Study identification
- NCT ID
- NCT00828009
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 70 participants
Conditions and interventions
Conditions
Interventions
- bevacizumab Biological
- Tecemotide Biological
- carboplatin Drug
- cyclophosphamide Drug
- paclitaxel Drug
- radiotherapy Radiation
Biological · Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 17, 2011 (Actual)
- Primary completion
- Aug 20, 2018 (Actual)
- Completion
- May 22, 2019 (Actual)
- Last update posted
- Jul 7, 2023
2011 – 2019
United States locations
- U.S. sites
- 88
- U.S. states
- 16
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Veterans Affairs Medical Center - Palo Alto | Palo Alto | California | 94304 | — |
| Stanford Cancer Center | Stanford | California | 94305-5824 | — |
| Medical Center of Central Georgia | Macon | Georgia | 31208 | — |
| St. Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | 60611-3013 | — |
| Hematology and Oncology Associates | Chicago | Illinois | 60611 | — |
| Saint Joseph Hospital | Chicago | Illinois | 60657 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Eureka Community Hospital | Eureka | Illinois | 61530 | — |
| Galesburg Clinic, PC | Galesburg | Illinois | 61401 | — |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Kellogg Cancer Care Center | Highland Park | Illinois | 60035 | — |
| Hinsdale Hematology Oncology Associates | Hinsdale | Illinois | 60521 | — |
| Provena St. Mary's Regional Cancer Center - Kankakee | Kankakee | Illinois | 60901 | — |
| North Shore Oncology and Hematology Associates, Limited - Libertyville | Libertyville | Illinois | 60048 | — |
| McDonough District Hospital | Macomb | Illinois | 61455 | — |
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline | Illinois | 61265 | — |
| Cancer Care and Hematology Specialists of Chicagoland - Niles | Niles | Illinois | 60714 | — |
| BroMenn Regional Medical Center | Normal | Illinois | 61761 | — |
| Community Cancer Center | Normal | Illinois | 61761 | — |
| Community Hospital of Ottawa | Ottawa | Illinois | 61350 | — |
| Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | 61554 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61615 | — |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF St. Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Community Hospital | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| Swedish-American Regional Cancer Center | Rockford | Illinois | 61104-2315 | — |
| Hematology Oncology Associates - Skokie | Skokie | Illinois | 60076 | — |
| Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| Howard Community Hospital | Kokomo | Indiana | 46904 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Saint Joseph Regional Medical Center | Mishawaka | Indiana | 46545-1470 | — |
| Cancer Center at Ball Memorial Hospital | Muncie | Indiana | 47303-3499 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| McFarland Clinic, PC | Ames | Iowa | 50010 | — |
| Medical Oncology and Hematology Associates - West Des Moines | Clive | Iowa | 50325 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309 | — |
| John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | 50314 | — |
| Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines | Iowa | 50316 | — |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center - Sioux City | Sioux City | Iowa | 51102 | — |
| St. Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Tufts Medical Center Cancer Center | Boston | Massachusetts | 02111 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49001 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Lakeside Cancer Specialists, PLLC | Saint Joseph | Michigan | 49085 | — |
| Cancer Resource Center - Lincoln | Lincoln | Nebraska | 68510 | — |
| CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | — |
| Lakeside Hospital | Omaha | Nebraska | 68130 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131-2197 | — |
| Cancer Institute of New Jersey at Hamilton | Hamilton | New Jersey | 08690 | — |
| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Stony Brook University Cancer Center | Stony Brook | New York | 11794-9446 | — |
| Mercy Cancer Center at Mercy Medical Center | Canton | Ohio | 44708 | — |
| Case Comprehensive Cancer Center | Cleveland | Ohio | 44106-5065 | — |
| St. Rita's Medical Center | Lima | Ohio | 45801 | — |
| Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest | Allentown | Pennsylvania | 18105 | — |
| Geisinger Cancer Institute at Geisinger Health | Danville | Pennsylvania | 17822-0001 | — |
| PinnacleHealth Regional Cancer Center at Polyclinic Hospital | Harrisburg | Pennsylvania | 17110-2098 | — |
| Geisinger Hazleton Cancer Center | Hazleton | Pennsylvania | 18201 | — |
| Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | — |
| Pottstown Memorial Regional Cancer Center | Pottstown | Pennsylvania | 19464 | — |
| Geisinger Medical Group - Scenery Park | State College | Pennsylvania | 16801 | — |
| Mount Nittany Medical Center | State College | Pennsylvania | 16803 | — |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232-6838 | — |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | — |
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas | Texas | 75390 | — |
| West Virginia University Health Sciences Center - Charleston | Charleston | West Virginia | 25304 | — |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | 54601 | — |
| Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00828009, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 7, 2023 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00828009 live on ClinicalTrials.gov.