Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44
Public ClinicalTrials.gov record NCT00948766. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 24 Week, Prospective, Randomized, Parallel-group, Double-blind, Multi-center Study (ENA713DUS44) Comparing the Effects of Rivastigmine Patch 15 cm^2 vs. Rivastigmine Patch 5 cm^2 on ACTivities of Daily Living and CognitION in Patients With Severe Dementia of the Alzheimer's Type (ACTION) and a 24-week Open-label Extension to Study ENA713DUS44
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The core study assessed the efficacy of a higher dose of rivastigmine 13.3 mg/24 h transdermally (15 cm\^2 patch) compared to a lower dose of the rivastigmine 4.6 mg/24 h transdermally (5 cm\^2 patch) in patients with Severe Dementia of the Alzheimer's Type in a 24-week study. The extension study obtained additional safety and efficacy data, as well as provided the higher dose rivastigmine patch to all patients who completed the core study for an additional 24 weeks.
Study identification
- NCT ID
- NCT00948766
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 716 participants
Conditions and interventions
Conditions
Interventions
- Rivastigmine 4.6 mg/24 h (5 cm^2) Drug
- Rivastigmine 9.5 mg/24 h (10 cm^2) Drug
- Rivastigmine 13.3 mg/24 h (15 cm^2) Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2009 (Type not available)
- Primary completion
- Jan 2012 (Actual)
- Completion
- Jun 2012 (Actual)
- Last update posted
- Aug 28, 2013
2009 – 2012
United States locations
- U.S. sites
- 93
- U.S. states
- 29
- U.S. cities
- 87
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Advantage Inc./Neurological. Physicians of Arizona, Inc | Tempe | Arizona | 85282 | — |
| Northwest Neuro Specialist, PLLC | Tucson | Arizona | 86741 | — |
| IHS Research Center Inc. | Conway | Arkansas | 72034 | — |
| East Bay Physicians Medical Group | Berkeley | California | 94705 | — |
| ATP Clinical Research, Inc. | Costa Mesa | California | 92626 | — |
| Neuro Pain Medical Center | Fresno | California | 90502 | — |
| Margolin Brain Institute | Fresno | California | 93720 | — |
| Collaborative Neuroscience Network Inc. | Garden Grove | California | 92845 | — |
| PCND Neuroscience Research Institute Inc./The Center for Memory and Aging | Poway | California | 92064 | — |
| Anderson Clinical Research | Redlands | California | 92374 | — |
| San Francisco Clinical Research Center | San Francisco | California | 94109 | — |
| Neuropsychiatric Research Center of Orange County | Santa Ana | California | 92701 | — |
| California Neuroscience Research Medical Group, Inc. | Sherman Oaks | California | 91403 | — |
| Viking Clinical Research Center | Temecula | California | 92591 | — |
| Collaborative Neuroscience Network, Inc | Torrance | California | 90502 | — |
| Senior Care of Colorado | Aurora | Colorado | 80014 | — |
| Clinical Research Studies Dept. of Clinical Science and Medical Education | Boca Raton | Florida | 33431 | — |
| Quantum Laboratories Memory Disorder Center | Deerfield Beach | Florida | 33064 | — |
| Brain Matters Research, Inc. | Delray Beach | Florida | 33445 | — |
| Neurologic Consultants, PA | Fort Lauderdale | Florida | 33308 | — |
| White-Wilson Medical Center | Fort Walton Beach | Florida | 32547 | — |
| MD Clinical | Hallandale | Florida | 33009 | — |
| Sunrise Clinical Research, Inc | Hollywood | Florida | 33021 | — |
| Compass Research, LLC | Orlando | Florida | 32806 | — |
| Integrity Research, LLC | Pensacola | Florida | 32514 | — |
| Neurostudies, Inc. | Port Charlotte | Florida | 33952 | — |
| Stedman Clinical Trials, LLC | Tampa | Florida | 33613 | — |
| Center for Clinical Trials | Venice | Florida | 34285 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Alexian Brothers Neuroscience Institute | Elk Grove Village | Illinois | 60007 | — |
| Elkhart Clinic, LLC | Elkhart | Indiana | 46514 | — |
| Indiana University Medical Center | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| MidAmerica Neuroscience Reseach Institute | Lenexa | Kansas | 66214 | — |
| Precise Clinical Research Solutions | Manhattan | Kansas | 66502 | — |
| LSU Health Sciences Center/Department of Psychiatry Psychopharmacology Research Clinic | Shreveport | Louisiana | 71103 | — |
| J. Gary Booker, MD APMC | Shreveport | Louisiana | 71104 | — |
| Pharmasite Research | Baltimore | Maryland | 21208 | — |
| The Samuel and Alexia Bratton Memory Clinic, William Hill Inc | Easton | Maryland | 21601 | — |
| Neuroscience Research of the Berkshires | Pittsfield | Massachusetts | 01201 | — |
| Michigan Neurology Associates, P.C. | Clinton Township | Michigan | 48035 | — |
| Wayne State University/Detroit Medical center | Detroit | Michigan | 48201 | — |
| West Michigan Clinical Research | Muskegon | Michigan | 49442 | — |
| Orr & Associates Memory and Geriatric Behavioral Health Clinic | Saint Paul | Minnesota | 55114 | — |
| Neurological Research Clinic, Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| The Neuroscience Center | Ocean Springs | Mississippi | 39564 | — |
| St. Louis University | St Louis | Missouri | 63104 | — |
| Sky, LLC. | St Louis | Missouri | 63117 | — |
| Premier Psychiatric Research Institute, LLC | Lincoln | Nebraska | 68510 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | — |
| Memory Enhancement Center of America, Inc. | Eatontown | New Jersey | 07724 | — |
| NeuroCognitive Institute | Mount Arlington | New Jersey | 07856 | — |
| UMDNJ-Robert Wood Johnson Medical Center | New Brunswick | New Jersey | 08903 | — |
| Alzheimer's Research Corporation | Paterson | New Jersey | 08759 | — |
| UMDNJ-School of Osteopathic Medicine Center | Stratford | New Jersey | 08084 | — |
| Memory Enhancement Center of NJ | Toms River | New Jersey | 08755 | — |
| Upstate Clinical Research, LLC | Albany | New York | 12205 | — |
| Dent Neurological Institute | Amherst | New York | 14226 | — |
| Neurological Care of Central NY | Liverpool | New York | 13088 | — |
| Eastside Comprehensive medical Center, LLC | New York | New York | 10021 | — |
| Nathan S. Kline Institute for Psychiatric Research | Orangeburg | New York | 10962 | — |
| Behavioral Medical Research of Staten Island | Staten Island | New York | 10305 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| The Burke Rehabilitation Hospital | White Plains | New York | 10605 | — |
| Alzheimer's Memory Center | Charlotte | North Carolina | 28211 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Clinical Trials of America, Inc. | Winston-Salem | North Carolina | 27103 | — |
| Valley Medical Research | Centerville | Ohio | 45459 | — |
| University Neurology, Inc. | Cincinnati | Ohio | 45219 | — |
| Cognitive Assessment Clinic | Portland | Oregon | 97225 | — |
| Lehigh Center for Clinical Research | Allentown | Pennsylvania | 18104 | — |
| Paramount Clinical Research | Bridgeville | Pennsylvania | 15017 | — |
| Department of Veterans Affairs Medical Center | Coatesville | Pennsylvania | 19320 | — |
| Westmoreland Neurology associates, Inc. | Greensburg | Pennsylvania | 15601 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Research Protocol Management Specialists | Pittsburgh | Pennsylvania | 15243 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Psychiatric Consultants, PC | Franklin | Tennessee | 37067 | — |
| Volunteer Research Group | Knoxville | Tennessee | 37920 | — |
| Jacinto Medical Group, PA | Baytown | Texas | 77521 | — |
| Future Search Trials | Dallas | Texas | 75231 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| Innovative Clinical Trials | San Antonio | Texas | 78229 | — |
| Radiant Research Inc. | San Antonio | Texas | 78229 | — |
| Grayline Clinical Drug Trials | Wichita Falls | Texas | 76309 | — |
| The Memory Clinic | Bennington | Vermont | 05201 | — |
| TLC Neurology, P.L.L.C | Arlington | Virginia | 22205 | — |
| UVA Neurology | Charlottesville | Virginia | 22903 | — |
| Neurological Associates, Inc. | Richmond | Virginia | 23226 | — |
| Alliance Research Group, LLC | Richmond | Virginia | 23230 | — |
| The Center for Excellence in Aging and Geriatric Health | Williamsburg | Virginia | 23185 | — |
| Internal Medicine Northwest | Tacoma | Washington | 98405 | — |
| Independent Psychiatric Consultants, SC | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00948766, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2013 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00948766 live on ClinicalTrials.gov.