Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
Public ClinicalTrials.gov record NCT00950118. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. There are many different possible modes of inheritance for congenital anomalies, including autosomal dominant, autosomal recessive, and multifactorial. Multi-factorial inheritance is responsible for many common medical disorders, including hypertension, myocardial infarction, diabetes and cancer. This type of inheritance pattern appears to involve environmental factors as well as a combination of genetic variations that together can predispose to or produce congenital anomalies, such as congenital diaphragmatic hernia. Our study is designed to establish a small, well-defined genetic resource consisting of 1) Nuclear families suitable for linkage analysis by parametric,non-parametric (e.g. sib pairs, TDT) and association techniques, 2) Individuals with congenital diaphragmatic hernia who can be directly screened for allelic variation in candidate genes, and 3) Individuals who can serve as controls (are unaffected by congenital diaphragmatic hernia). Neonates and their families will be collected from homogenous and heterogeneous populations. By characterizing diverse populations, it should be possible to increase the likelihood of demonstration of genetic variation in selected candidate genes that can then be used in association and linkage studies in individual subjects with congenital diaphragmatic hernia.
Study identification
- NCT ID
- NCT00950118
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 3,000 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2005
- Primary completion
- Aug 31, 2026
- Completion
- Aug 31, 2026
- Last update posted
- Dec 11, 2025
2005 – 2026
United States locations
- U.S. sites
- 13
- U.S. states
- 11
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rush Hospital | Chicago | Illinois | 60612 | Recruiting |
| University of Michigan/ CS Mott Children's Hospital | Ann Arbor | Michigan | 48167-5245 | Recruiting |
| Washington University Medical Center/ St. Louis Children's Hospital | St Louis | Missouri | 63110 | Recruiting |
| Children's Hospital of Omaha/ University of Nebraska | Omaha | Nebraska | 68114 | Recruiting |
| Northwell Health | Manhasset | New York | 11030 | Recruiting |
| New York University, Hassenfeld Children's Hospital at NYU Langone Health | New York | New York | 10016 | Recruiting |
| Morgan Stanley Children's Hospital of New York- Presbyterian (Columbia University Medical Center) | New York | New York | 10032 | Recruiting |
| Cincinnati Children's Hospital and Medical Center/ University of Cincinnati | Cincinnati | Ohio | 45229 | Recruiting |
| Oregon Health & Science University, Doernbecher Children's Hospital | Portland | Oregon | 97239 | Recruiting |
| Children's Hospital of Pittsburgh/ University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Monroe Carrell Jr Children's Hospital at Vanderbilt | Nashville | Tennessee | 37232 | Completed |
| UT Southwestern Medical Center, Children's Health, Dallas | Dallas | Texas | 75235 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00950118, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2025 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00950118 live on ClinicalTrials.gov.