ClinicalTrials.gov record
A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Participants With Metastatic Breast Cancer (MARIANNE)
ClinicalTrials.gov ID: NCT01120184
Public ClinicalTrials.gov record NCT01120184. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 4, 2026, 9:52 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, 3 Arm, Multicenter, Phase III Study to Evaluate the Efficacy and the Safety of T-DM1 Combined With Pertuzumab or T-DM1 Combined With Pertuzumab-Placebo (Blinded for Pertuzumab), Versus the Combination of Trastuzumab Plus Taxane, as First Line Treatment in HER2 Positive Progressive or Recurrent Locally Advanced or Metastatic Breast Cancer
Study identification
- NCT ID
- NCT01120184
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 1,095 participants
Conditions and interventions
Conditions
Interventions
- docetaxel Drug
- paclitaxel Drug
- pertuzumab Drug
- pertuzumab-placebo Drug
- trastuzumab [Herceptin] Drug
- trastuzumab emtansine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 30, 2010
- Primary completion
- Sep 29, 2014
- Completion
- Sep 15, 2016
- Last update posted
- Mar 3, 2024
2010 – 2016
United States locations
- U.S. sites
- 62
- U.S. states
- 30
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Arkansas For Medical Sciences; Arkansas Cancer Research Center | Little Rock | Arkansas | 72204 | — |
| Scripps Cancer Center | La Jolla | California | 92037 | — |
| University of California; Moores Cancer Center | La Jolla | California | 92093 | — |
| Clnc L Trials & Rsch Assoc-Inc | Montebello | California | 90640 | — |
| Southern California Kaiser Permanente | San Diego | California | 92108 | — |
| Breastlink Medical Group Inc | Santa Ana | California | 92705 | — |
| Kaiser Permanente; Oncology Clinical Trials | Vallejo | California | 94589 | — |
| Smilow Cancer Hospital at Yale New Haven | New Haven | Connecticut | 06510 | — |
| Innovative Medical Research of South Florida | Aventura | Florida | 33180 | — |
| Northwest Oncology/ Hematology Assoc. | Coral Springs | Florida | 33065-5701 | — |
| Florida Cancer Specialists; SCRI | Fort Myers | Florida | 33901 | — |
| Mayo Clinic-Jacksonville | Jacksonville | Florida | 32224 | — |
| Uni of Miami School of Medicine; Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| University Cancer & Blood Center, LLC; Research | Athens | Georgia | 30607 | — |
| Cancer Research Center of Hawaii; Clinical Sciences | Honolulu | Hawaii | 96813 | — |
| Mountain States Tumor Inst. | Boise | Idaho | 83712 | — |
| Uni of Chicago | Chicago | Illinois | 60637 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Loyola University Med Center | Maywood | Illinois | 60153 | — |
| Illinois Cancer Care | Peoria | Illinois | 61615 | — |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Horizon Oncology Research, Inc. | Lafayette | Indiana | 47905 | — |
| James Graham Brown Cancer Center, University of Louisville | Louisville | Kentucky | 40202 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Anne Arundel Health System Research Instit-Annapolis Oncology Ctr | Annapolis | Maryland | 21401 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Spectrum Health Grand Rapids | Grand Rapids | Michigan | 49503 | — |
| University of Minnesota. | Minneapolis | Minnesota | 55454 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55902 | — |
| Mercy Clinic Cancer & Hematology | Springfield | Missouri | 65804 | — |
| St. John'S Mercy Medical Center; David C. Pratt Cancer Center | St Louis | Missouri | 63141 | — |
| Dartmouth Hitchcock Med Center | Lebanon | New Hampshire | 03756 | — |
| Hackensack Uni Medical Center; Northern Nj Cancer Center | Hackensack | New Jersey | 07601 | — |
| Cancer Inst. of New Jersey | New Brunswick | New Jersey | 08901 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Queens Medical Associates | Fresh Meadows | New York | 11366 | — |
| Queens Hospital Center | Jamaica | New York | 11432 | — |
| Arena Oncology Associates | Lake Success | New York | 11042 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Weill Medical College of Cornell Uni | New York | New York | 10065 | — |
| Carolinas Hem-Oncology Assoc | Charlotte | North Carolina | 28203 | — |
| Carolina Oncology Specialists, PA - Hickory | Hickory | North Carolina | 28602 | — |
| Marion L. Shepard Cancer Center | Washington | North Carolina | 27889 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58102 | — |
| Oncology Hematology Care - SCRI | Cincinnati | Ohio | 45242 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Charleston Oncology, P .A | Charleston | South Carolina | 29414 | — |
| Medical University of SC (MUSC) | Charleston | South Carolina | 29425 | — |
| South Carolina Oncology Associates - SCRI | Columbia | South Carolina | 29210 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| SCRI Tennessee Oncology Chattanooga | Chattanooga | Tennessee | 37404 | — |
| West Clinic | Germantown | Tennessee | 38138 | — |
| Tennessee Onc., PLLC - SCRI | Nashville | Tennessee | 37203 | — |
| Vanderbilt-Ingram Cancer Ctr | Nashville | Tennessee | 37232 | — |
| The Don & Sybil Harrington Cancer Center; Department of Clinical Research | Amarillo | Texas | 79106 | — |
| Uni of Texas Southwestern Medical Center | Dallas | Texas | 75390-9063 | — |
| Uni of Texas - Md Anderson Cancer Center; Dept of Breast Medical Oncology | Houston | Texas | 77030 | — |
| Northern Utah Associates | Ogden | Utah | 84403 | — |
| The Providence Regional Medical Center Everett | Everett | Washington | 98201 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 195 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01120184, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 3, 2024 · Synced May 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01120184 live on ClinicalTrials.gov.