Study of the Safety and Efficacy of TH-302 in Combination With Gemcitabine Compared With Gemcitabine Alone in Previously Untreated Patients With Pancreatic Adenocarcinoma
Public ClinicalTrials.gov record NCT01144455. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Cross-over Phase 2 Study of the Safety and Efficacy of Two Dose Levels of TH-302 in Combination With Gemcitabine Compared With Gemcitabine Alone in Previously Untreated Patients With Locally Advanced Unresectable or Metastatic Pancreatic Adenocarcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether Gemcitabine versus Gemcitabine and TH-302 are effective in the treatment of subjects with first-line metastatic pancreatic adenocarcinoma.
Study identification
- NCT ID
- NCT01144455
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 214 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2010
- Primary completion
- Aug 31, 2013
- Completion
- Nov 30, 2014
- Last update posted
- May 10, 2025
2010 – 2014
United States locations
- U.S. sites
- 59
- U.S. states
- 29
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham Hematology and Oncology Associates, LLC | Birmingham | Alabama | 35223 | — |
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | — |
| Arizona Oncology Associates, PC - HOPE | Tucson | Arizona | 85704 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| Saint Edward Mercy Medical Center | Fort Smith | Arkansas | 72917 | — |
| Disney Family Cancer Center | Burbank | California | 91505 | — |
| Scripps Clinical Research Services | La Jolla | California | 92037 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Palo Alto Medical Foundation | Mountain View | California | 94040 | — |
| Los Palos Oncology and Hematology | Salinas | California | 93901 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| California Pacific Medical Center | San Francisco | California | 94115 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | — |
| Hematology Oncology Associates, PC | Stamford | Connecticut | 06902 | — |
| Florida Cancer Institute - New Hope | New Port Richey | Florida | 34655 | — |
| Ocala Oncology Center | Ocala | Florida | 34471 | — |
| Martin Memorial Cancer Center | Stuart | Florida | 34994 | — |
| Atlanta Cancer Care | Atlanta | Georgia | 30342 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Carle Cancer Center | Urbana | Illinois | 61901 | — |
| Indiana University Melvin and Bren Simon Cancer | Indianapolis | Indiana | 46202 | — |
| Purchase Cancer Group | Paducah | Kentucky | 42002 | — |
| Medical Oncology | Baton Rouge | Louisiana | 70809 | — |
| Ochsner Cancer Institute | New Orleans | Louisiana | 70121 | — |
| LSU Health Sciences Center - Feist Weiller Cancer Center | Shreveport | Louisiana | 71130 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Massachusetts Medical Center | Worcester | Massachusetts | 01655 | — |
| Virgina Piper Cancer Institute | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Hematology and Oncology Associates at BridgePoint | Tupelo | Mississippi | 38801 | — |
| Missouri Cancer Associates | Columbia | Missouri | 65201 | — |
| Montana Cancer Institute Foundation | Missoula | Montana | 59802 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| New York Oncology Hematology, P.C. | Hudson | New York | 12534 | — |
| Cancer Care of Western North Carolina, PA | Asheville | North Carolina | 28801 | — |
| Alamance Oncology Hematolgy Associates | Burlington | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Carolina Oncology Specialists, PA | Hickory | North Carolina | 28602 | — |
| Emerywood Hematology and Oncology | High Point | North Carolina | 27262 | — |
| Signal Point Clinical Research Center | Middletown | Ohio | 45042 | — |
| Kaiser Permanente Northwest Region Oncology Hematology | Portland | Oregon | 97227 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | — |
| Greater Philadelphia Cancer and Hematology Specialists, P.C. | Philadelphia | Pennsylvania | 19114 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15232 | — |
| Institute for Translational Oncology Research (ITOR) | Greenville | South Carolina | 29605 | — |
| Vanderbilt University Medical Center, Div. of Medical Oncology | Nashville | Tennessee | 37232 | — |
| Texas Oncology-Beaumont, Mamie McFaddin Ward Cancer Center | Beaumont | Texas | 77702 | — |
| Texas Oncology-Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| Texas Oncology- Fort Worth - 12th Avenue | Fort Worth | Texas | 76104 | — |
| Texas Oncology-Seton Williamson | Round Rock | Texas | 78665 | — |
| Texas Oncology-Sherman | Sherman | Texas | 75090 | — |
| Texas Oncology-Wichita Falls Texoma Cancer Center | Wichita Falls | Texas | 76310 | — |
| Fairfax Northern Virginia Hematology Oncology, PC | Fairfax | Virginia | 22031 | — |
| Providence Everett Regional Medical Center, Cancer Research Dept. | Everett | Washington | 98201 | — |
| Columbia Basin Hematology and Oncology0 | Kennewick | Washington | 99336 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01144455, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 10, 2025 · Synced Sep 24, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01144455 live on ClinicalTrials.gov.