Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer
Public ClinicalTrials.gov record NCT01297491. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open Label Two-stage Study of Orally Administered BKM120 in Patients With Metastatic Non-small Cell Lung Cancer With Activated PI3K Pathway
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this two-stage phase II study is to assess the efficacy of BKM120, as measured by determining the progression free survival (PFS), in patients with pretreated metastatic Non-small Cell Lung Cancer (NSCLC) that exhibits PI3K pathway activation. BKM120 will be investigated in two groups of NSCLC patients according to the histology of the cancer: squamous and non-squamous.
Study identification
- NCT ID
- NCT01297491
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 63 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2011 (Type not available)
- Primary completion
- Oct 2014 (Actual)
- Completion
- Oct 2014 (Actual)
- Last update posted
- Mar 11, 2016
2011 – 2014
United States locations
- U.S. sites
- 32
- U.S. states
- 22
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer and Research Centers SC | Chandler | Arizona | 85224 | — |
| Arizona Oncology Associates Tucson (Rudasill & La Cholla) | Phoenix | Arizona | — | — |
| Mayo Clinic - Arizona Mayo Scottsdale AZ | Scottsdale | Arizona | 85259 | — |
| Highlands Oncology Group Dept of Highlands Oncology Grp | Fayetteville | Arkansas | 72753 | — |
| Cedars Sinai Medical Center Dept.of Cedars-Sinai Med. Ctr. | Los Angeles | California | 90048 | — |
| University of California at San Diego, Moores Cancer Ctr SC | San Diego | California | 92103 | — |
| University of Colorado Univ CO | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Centers Dept. of Rocky Mountain Cancer | Greenwood Village | Colorado | 80218 | — |
| H. Lee Moffitt Cancer Center & Research Institute H Lee Moffitt | Tampa | Florida | 33612 | — |
| Emory University School of Medicine/Winship Cancer Institute Emory 2 | Atlanta | Georgia | 30322 | — |
| Rush University Medical Center SC | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Center Unvi Chi | Chicago | Illinois | 60637 | — |
| University of Kansas Cancer Center Univ of KS | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital Mass General | Boston | Massachusetts | 02114 | — |
| Fallon Clinic at Worcester Medical Center Fallon Clinic Worcester Med | Worcester | Massachusetts | 01608 | — |
| Karmanos Cancer Institute Wayne St Karmanos | Detroit | Michigan | 48201 | — |
| Washington University School of Medicine Washington University (16) | St Louis | Missouri | 63110 | — |
| Hematology Oncology Associates of Northern New Jersey PA DeptofHem-OncofNorthern NJ (2) | Morristown | New Jersey | 07962 | — |
| Overlook Hospital - Carol G Simon Cancer Center Carol G Simon | Summit | New Jersey | 07901 | — |
| Roswell Park Cancer Institute Rosewell | Buffalo | New York | 14263 | — |
| Memorial Sloan Kettering Cancer Center Sloan Kettering | New York | New York | 90033 | — |
| Duke University Medical Center Duke 2 | Durham | North Carolina | 27710 | — |
| MetroHealth Medical Center Dept.ofMetroHealthMedCtr.(2) | Cleveland | Ohio | 44109-1998 | — |
| University of Oklahoma Health Sciences Center Dept. of Oklahoma Univ. HSC | Oklahoma City | Oklahoma | 73104 | — |
| Northwest Cancer Specialists Compass Oncology -BKM | Portland | Oregon | 97210 | — |
| University of Pittsburgh Medical Center SC-2 | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina MUSC | Charleston | South Carolina | 29425 | — |
| Baylor Health Care System/Sammons Cancer Center Baylor Texas Oncology | Dallas | Texas | 75246 | — |
| Texas Oncology South Texas Oncology | Dallas | Texas | 75251 | — |
| U of TX Southwestern Medical Center - SimmonsCompCancerCtr Clinical Research Office | Dallas | Texas | 75390-9151 | — |
| Virginia Oncology Associates VOA - Lake Wright (2) | *see Various Departments* | Virginia | 23502 | — |
| University of Wisconsin Univ WIsc 2 | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 60 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01297491, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 11, 2016 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01297491 live on ClinicalTrials.gov.