Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
Public ClinicalTrials.gov record NCT01300013. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to evaluate the effect of 48 hours of intravenous (IV) omecamtiv mecarbil compared with placebo on dyspnea in subjects with left ventricular systolic dysfunction hospitalized for acute heart failure. This is a multicenter, randomized, double-blind, placebo-controlled study with 3 dose cohorts enrolled sequentially in order of ascending dose strength of omecamtiv mecarbil. In each cohort, subjects are randomized 1:1 to omecamtiv mecarbil or placebo.
Study identification
- NCT ID
- NCT01300013
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 614 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2011 (Type not available)
- Primary completion
- Apr 2013 (Actual)
- Completion
- Sep 2013 (Actual)
- Last update posted
- Jul 27, 2021
2011 – 2013
United States locations
- U.S. sites
- 45
- U.S. states
- 22
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Inglewood | California | 90301 | — |
| Research Site | La Jolla | California | 92037 | — |
| Research Site | San Francisco | California | 94121 | — |
| Research Site | Danbury | Connecticut | 06810 | — |
| Research Site | Newark | Delaware | 19718 | — |
| Research Site | Atlantis | Florida | 33462 | — |
| Research Site | Clearwater | Florida | 33756 | — |
| Research Site | Fort Lauderdale | Florida | 33308 | — |
| Research Site | Miami | Florida | 33133 | — |
| Research Site | Orlando | Florida | 32803 | — |
| Research Site | Atlanta | Georgia | 30322 | — |
| Research Site | Chicago | Illinois | 60611 | — |
| Research Site | Peoria | Illinois | 61636 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Detroit | Michigan | 48201 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Novi | Michigan | 48374 | — |
| Research Site | Minneapolis | Minnesota | 55417 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | Lincoln | Nebraska | 68506 | — |
| Research Site | Newark | New Jersey | 07103 | — |
| Research Site | Cortlandt Manor | New York | 10567 | — |
| Research Site | Roslyn | New York | 11576 | — |
| Research Site | The Bronx | New York | 10467 | — |
| Research Site | Chapel Hill | North Carolina | 27599 | — |
| Research Site | Charlotte | North Carolina | 28204 | — |
| Research Site | Durham | North Carolina | 27705 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cincinnati | Ohio | 45220 | — |
| Research Site | Cincinnati | Ohio | 45267 | — |
| Research Site | Cleveland | Ohio | 44109 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Fairfield | Ohio | 45014 | — |
| Research Site | Oklahoma City | Oklahoma | 73120 | — |
| Research Site | Portland | Oregon | 97239 | — |
| Research Site | Charleston | South Carolina | 29425 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Memphis | Tennessee | 38120 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Nashville | Tennessee | 37232-8802 | — |
| Research Site | Tullahoma | Tennessee | 37388 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Murray | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 105 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01300013, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 27, 2021 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01300013 live on ClinicalTrials.gov.