Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels
Public ClinicalTrials.gov record NCT01375777. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Placebo- and Ezetimibe-controlled, Dose-ranging Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C in Hypercholesterolemic Subjects With a 10-year Framingham Risk Score of 10% or Less
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective was to evaluate the effect of 12 weeks of subcutaneous evolocumab (AMG 145) every 2 weeks (Q2W) or every 4 weeks (Q4W), compared with placebo, on the percent change from baseline in LDL-C when used as monotherapy in adults with hypercholesterolemia.
Study identification
- NCT ID
- NCT01375777
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 411 participants
Conditions and interventions
Conditions
Interventions
- Evolocumab Biological
- Ezetimibe Drug
- Placebo to Evolocumab Other
Biological · Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 6, 2011 (Actual)
- Primary completion
- Mar 2, 2012 (Actual)
- Completion
- Mar 2, 2012 (Actual)
- Last update posted
- Nov 8, 2022
2011 – 2012
United States locations
- U.S. sites
- 41
- U.S. states
- 23
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35216 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Encinitas | California | 92024 | — |
| Research Site | Inglewood | California | 90301 | — |
| Research Site | San Diego | California | 92111 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | DeLand | Florida | 32720 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Jacksonville | Florida | 32223 | — |
| Research Site | Miami | Florida | 33143 | — |
| Research Site | Miami | Florida | 33144 | — |
| Research Site | Ponte Vedra | Florida | 32081 | — |
| Research Site | Sanford | Florida | 32771 | — |
| Research Site | Decatur | Georgia | 30035 | — |
| Research Site | Chicago | Illinois | 60610 | — |
| Research Site | Indianapolis | Indiana | 46260 | — |
| Research Site | Louisville | Kentucky | 40213 | — |
| Research Site | Bethesda | Maryland | 20817 | — |
| Research Site | Brockton | Massachusetts | 02301 | — |
| Research Site | Brooklyn Center | Minnesota | 55430 | — |
| Research Site | Las Vegas | Nevada | 89148 | — |
| Research Site | Endwell | New York | 13760 | — |
| Research Site | New Windsor | New York | 12553 | — |
| Research Site | Raleigh | North Carolina | 27609 | — |
| Research Site | Raleigh | North Carolina | 27612 | — |
| Research Site | Fargo | North Dakota | 58103 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cincinnati | Ohio | 45246 | — |
| Research Site | Cleveland | Ohio | 44122 | — |
| Research Site | Norman | Oklahoma | 73069 | — |
| Research Site | Oklahoma City | Oklahoma | 73103 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | Rapid City | South Dakota | 57702 | — |
| Research Site | Arlington | Texas | 76014 | — |
| Research Site | Boerne | Texas | 78006 | — |
| Research Site | San Antonio | Texas | 78205 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Richmond | Virginia | 23294 | — |
| Research Site | Renton | Washington | 98057 | — |
| Research Site | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01375777, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 8, 2022 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01375777 live on ClinicalTrials.gov.