A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma
Public ClinicalTrials.gov record NCT01689519. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Double-Blind, Placebo-Controlled Study of Vemurafenib Versus Vemurafenib Plus GDC-0973 in Previously Untreated BRAF^600-Mutation Positive Patients With Unresectable Locally Advanced or Metastatic Melanoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To evaluate the efficacy of vemurafenib in combination with cobimetinib (GDC-0973), compared with vemurafenib and placebo, in previously untreated BRAF V600 mutation-positive patients with unresectable locally advanced or metastatic melanoma, as measured by progression-free survival (PFS), assessed by the study site investigator.
Study identification
- NCT ID
- NCT01689519
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 495 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 8, 2013 (Actual)
- Primary completion
- May 9, 2014 (Actual)
- Completion
- Jul 21, 2019 (Actual)
- Last update posted
- May 2, 2022
2013 – 2019
United States locations
- U.S. sites
- 20
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| The Angeles Clinic and Research Institute - W LA Office | Los Angeles | California | 90025 | — |
| University of California Davis Health System | Sacramento | California | 95817 | — |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | — |
| University Of Colorado | Aurora | Colorado | 80045 | — |
| Florida Cancer Specialists - Broadway | Fort Myers | Florida | 33901 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Orlando Health Inc. | Orlando | Florida | 32806 | — |
| Northwestern Center For Clinical Research | Chicago | Illinois | 60611 | — |
| Uni of Kansas Medical Center; Dept of Neurology | Kansas City | Kansas | 66160-7314 | — |
| U of L - Physicians Pulmonology; Dept of Neuroradiology and Dept of Diagnostic Radiology | Louisville | Kentucky | 40202 | — |
| Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology | St Louis | Missouri | 63108 | — |
| Dartmouth-Hitchcock Medical Center; Department of Medicine | Lebanon | New Hampshire | 03756 | — |
| Novant Health Oncology Specialists | Winston-Salem | North Carolina | 27103 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| St. Luke's University Health network | Bethlehem | Pennsylvania | 18015 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15261 | — |
| Rhode Island Hospital; Investigational Services | Providence | Rhode Island | 2903 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 136 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01689519, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2022 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01689519 live on ClinicalTrials.gov.