LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2
Public ClinicalTrials.gov record NCT01763866. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo and Ezetimibe Controlled, Multicenter Study to Evaluate Safety, Tolerability and Efficacy of AMG 145 on LDL-C in Combination With Statin Therapy in Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective was to evaluate the effect of 12 weeks of evolocumab administered subcutaneously every 2 weeks (Q2W) and monthly (QM) when used in combination with a statin, compared with placebo, on percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia and mixed dyslipidemia.
Study identification
- NCT ID
- NCT01763866
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,067 participants
Conditions and interventions
Conditions
Interventions
- Evolocumab Biological
- Ezetimibe Drug
- Placebo to Evolocumab Drug
- Placebo to Ezetimibe Drug
- Atorvastatin Drug
- Rosuvastatin Drug
- Simvastatin Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 15, 2013 (Actual)
- Primary completion
- Nov 12, 2013 (Actual)
- Completion
- Dec 4, 2013 (Actual)
- Last update posted
- Nov 8, 2022
2013
United States locations
- U.S. sites
- 65
- U.S. states
- 28
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35294 | — |
| Research Site | Glendale | Arizona | 85306 | — |
| Research Site | Tucson | Arizona | 85710 | — |
| Research Site | Tucson | Arizona | 85712 | — |
| Research Site | Carmichael | California | 95608 | — |
| Research Site | Encino | California | 91436 | — |
| Research Site | Long Beach | California | 90822 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | San Diego | California | 92123 | — |
| Research Site | Santa Ana | California | 92705 | — |
| Research Site | Santa Rosa | California | 95405 | — |
| Research Site | Thousand Oaks | California | 91360 | — |
| Research Site | Torrance | California | 90509 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | Westlake Village | California | 91361 | — |
| Research Site | Littleton | Colorado | 80120 | — |
| Research Site | Daytona Beach | Florida | 32117 | — |
| Research Site | Jacksonville | Florida | 32223 | — |
| Research Site | Melbourne | Florida | 32901 | — |
| Research Site | Miami | Florida | 33173 | — |
| Research Site | Port Charlotte | Florida | 33952 | — |
| Research Site | Atlanta | Georgia | 30328 | — |
| Research Site | Atlanta | Georgia | 30342 | — |
| Research Site | Boise | Idaho | 83704 | — |
| Research Site | Hammond | Indiana | 46320 | — |
| Research Site | Indianapolis | Indiana | 46237 | — |
| Research Site | Valparaiso | Indiana | 46383 | — |
| Research Site | Iowa City | Iowa | 52242 | — |
| Research Site | Crestview Hills | Kentucky | 41017 | — |
| Research Site | Monroe | Louisiana | 71203 | — |
| Research Site | Auburn | Maine | 04210 | — |
| Research Site | Bangor | Maine | 04401 | — |
| Research Site | Portland | Maine | 04101 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Ypsilanti | Michigan | 48197 | — |
| Research Site | Tupelo | Mississippi | 38801 | — |
| Research Site | Billings | Montana | 59102 | — |
| Research Site | Voorhees Township | New Jersey | 08043 | — |
| Research Site | Manlius | New York | 13104 | — |
| Research Site | Rochester | New York | 14609 | — |
| Research Site | Syracuse | New York | 13210 | — |
| Research Site | Williamsville | New York | 14221 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Cadiz | Ohio | 43907 | — |
| Research Site | Canton | Ohio | 44708 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cincinnati | Ohio | 45227 | — |
| Research Site | Dayton | Ohio | 45414 | — |
| Research Site | Mansfield | Ohio | 44906 | — |
| Research Site | Marion | Ohio | 43302 | — |
| Research Site | Sandusky | Ohio | 44870 | — |
| Research Site | Norman | Oklahoma | 73069 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Pittsburgh | Pennsylvania | 15216 | — |
| Research Site | York | Pennsylvania | 17405 | — |
| Research Site | Florence | South Carolina | 29501 | — |
| Research Site | Rapid City | South Dakota | 57701 | — |
| Research Site | Jackson | Tennessee | 38301 | — |
| Research Site | Jackson | Tennessee | 38305 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | Houston | Texas | 77074 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Suffolk | Virginia | 23435 | — |
| Research Site | Winchester | Virginia | 22601 | — |
| Research Site | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 179 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01763866, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 8, 2022 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01763866 live on ClinicalTrials.gov.