Phase 2 Study of Docetaxel +/- OGX-427 in Patients With Relapsed or Refractory Metastatic Bladder Cancer
Public ClinicalTrials.gov record NCT01780545. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The Borealis-2 Clinical Trial: A Randomized Phase 2 Study Comparing Docetaxel Alone to Docetaxel in Combination With OGX-427 in Patients With Relapsed or Refractory Metastatic Urothelial Carcinoma After Receiving a Platinum-containing Regimen: Hoosier Cancer Research Network GU12-160
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, open-label Phase 2 clinical trial to evaluate whether suppression of Hsp27 (Heat shock protein 27) production using OGX-427, a second-generation antisense oligonucleotide (ASO), in combination with docetaxel can prolong survival time compared to docetaxel alone in participants with locally advanced or metastatic urothelial carcinoma (UC) that are relapsed or refractory after receiving a platinum-containing regimen.
Study identification
- NCT ID
- NCT01780545
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2013 (Type not available)
- Primary completion
- Oct 2017 (Actual)
- Completion
- Oct 2017 (Actual)
- Last update posted
- Jul 11, 2022
2013 – 2017
United States locations
- U.S. sites
- 35
- U.S. states
- 16
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hematology Oncology Clinic at Medical West | Birmingham | Alabama | 35294 | — |
| City of Hope: Duarte | Duarte | California | 91010 | — |
| City of Hope: Antelope Valley | Lancaster | California | 93534 | — |
| USC: Norris Comprehensive Cancer Center | Los Angeles | California | 90089 | — |
| UCLA: Jonsson Comprehensive Cancer Center | Los Angeles | California | 90095 | — |
| IU Health Goshen Hospital | Goshen | Indiana | 46527 | — |
| Indiana University Melvin & Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| IU Health Central Indiana Cancer Centers | Indianapolis | Indiana | 46219 | — |
| IU Health at Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| University of Maryland: Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University: Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21231 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| University of Michigan Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Medical Center: Norris Cotton Cancer Center | Manchester | New Hampshire | 03102 | — |
| Memorial Sloan-Kettering Cancer Center: Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| John Theurer Cancer Center: Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| University of New Mexico Cancer Center: Albuquerque | Albuquerque | New Mexico | 87131 | — |
| University of New Mexico Cancer Center: Las Cruces | Las Cruces | New Mexico | 88011 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Memorial Sloan-Kettering Cancer Center: Commack | Commack | New York | 11725 | — |
| New York University Clinical Cancer Center | New York | New York | 10016 | — |
| Memorial Sloan-Kettering Cancer Center: Main Campus | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Memorial Sloan-Kettering Cancer Center: Rockville Centre | Rockville Centre | New York | 11570 | — |
| Memorial Sloan-Kettering Cancer Center: Sleepy Hollow | Sleepy Hollow | New York | 10591 | — |
| University Hospitals Seidman Cancer Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic: Taussig Cancer Institute | Cleveland | Ohio | 44195 | — |
| Lake Health: University Hospitals Seidman Cancer Center | Mentor | Ohio | 44060 | — |
| UHHS Chagrin Highlands: Seidman Cancer Center | Orange | Ohio | 44122 | — |
| Thomas Jefferson University: Kimmel Cancer Center | Philadelphia | Pennsylvania | 19107 | — |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Froedtert & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01780545, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 11, 2022 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01780545 live on ClinicalTrials.gov.