Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma
Public ClinicalTrials.gov record NCT01909453. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 2-part Phase III Randomized, Open Label, Multicenter Study of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma
Study identification
- NCT ID
- NCT01909453
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 921 participants
Conditions and interventions
Conditions
Interventions
- LGX818 Drug
- MEK162 Drug
- vemurafenib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2013
- Primary completion
- Nov 8, 2016
- Completion
- Sep 2, 2024
- Last update posted
- Feb 26, 2026
2013 – 2024
United States locations
- U.S. sites
- 50
- U.S. states
- 21
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Consultants of Alabama P.C. | Birmingham | Alabama | 35233 | — |
| UAB Callahan Eye Hospital | Birmingham | Alabama | 35233 | — |
| UAB Comprehensive Cancer Center | Birmingham | Alabama | 35233 | — |
| UAB The Kirklin Clinic | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35243 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Oncology Associates | Tucson | Arizona | 85710 | — |
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | — |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group - Fayetteville | Springdale | Arkansas | 72762 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| Rocky Mountain Cancer Centers (Williams) - USOR | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers (Williams) - USOR | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers | Lakewood | Colorado | 80228 | — |
| Specialty Eye Care | Parker | Colorado | 80134 | — |
| Rocky Mountain Cancer Centers | Pueblo | Colorado | 81008 | — |
| University Cancer Institute | Boynton Beach | Florida | 33426 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Eye & Ear Infirmary- Opthalmology | Chicago | Illinois | 60612 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| University of Illinois Hospital and Health Sciences System - Investigational Drug Service | Chicago | Illinois | 60612 | — |
| University of Illinois Hospital and Health Sciences System | Chicago | Illinois | 60612 | — |
| University of Illinois Medical Center | Chicago | Illinois | 60612 | — |
| Oncology Specialists, SC | Niles | Illinois | 60714 | — |
| Goshen Center For Cancer Care | Goshen | Indiana | 46526 | — |
| Lack's Cancer Center at Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Mercy Health Hauenstein Neuroscience Center Neuro-Ophthalmology (Clinic) | Grand Rapids | Michigan | 49503 | — |
| Retina Specialists of Michigan | Grand Rapids | Michigan | 49525 | — |
| Hattiesburg Clinic Oncology Hem | Hattiesburg | Mississippi | 39401 | — |
| Jackson Oncology Associates - St. Dominic Hospital | Jackson | Mississippi | 39202 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Investigational Drug Service, Department of Pharmacy (Investigational Product) | Rochester | New York | 14642 | — |
| University of Rochester Medical Center - PPDS | Rochester | New York | 14642 | — |
| Tulsa Cancer Institute PLLC | Tulsa | Oklahoma | 74146 | — |
| University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15232 | — |
| Sanford Cancer Center Oncology Clinic & Pharmacy | Sioux Falls | South Dakota | 57104 | — |
| University of Tennessee Medical Center Cancer Institute | Knoxville | Tennessee | 37920 | — |
| Dr. Dennis B. Kay (Ophthalmologist) | Dallas | Texas | 75231 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Virginia Cancer Specialists, PC | Alexandria | Virginia | 22304 | — |
| Virginia Cancer Specialists | Arlington | Virginia | 22205 | — |
| Virginia Cancer Specialists (Leesburg) - USOR | Fairfax | Virginia | 22031 | — |
| Northern Virginia Ophthalmology Associates | Falls Church | Virginia | 22044 | — |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | — |
| Wenatchee Valley Hospital & Clinics | Wenatchee | Washington | 98801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 232 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01909453, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 26, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01909453 live on ClinicalTrials.gov.