Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer
Public ClinicalTrials.gov record NCT01997333. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Multicenter Pivotal Study of CDX-011 (CR011-vcMMAE)in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer (The METRIC Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to see whether CDX-011 (glembatumumab vedotin, an antibody-drug conjugate) is effective in treating patients who have advanced Triple-Negative Breast Cancer (TNBC), and whose tumor cells make a protein called glycoprotein NMB (gpNMB), which CDX-011 binds to. The study will also further characterize the safety of CDX-011 treatment in this patient population.
Study identification
- NCT ID
- NCT01997333
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 327 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2013 (Type not available)
- Primary completion
- Nov 30, 2017 (Actual)
- Completion
- Aug 7, 2018 (Actual)
- Last update posted
- Mar 8, 2019
2013 – 2018
United States locations
- U.S. sites
- 71
- U.S. states
- 22
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Oncology | Birmingham | Alabama | 35211 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| University of South Alabama Cancer Research Insititute | Mobile | Alabama | 36604 | — |
| Arizona Cancer Research Alliance | Glendale | Arizona | 85304 | — |
| Arizona Cancer Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Compassionate Care Research Group | Fountain Valley | California | 92708 | — |
| St. Jude Heritage Medical Group | Fullerton | California | 92835 | — |
| USC Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | 90033 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Pacific Cancer Care | Salinas | California | 93901 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| Kaiser Permaente | Vallejo | California | 94589 | — |
| Wellness Hematology Oncology | West Hills | California | 91307 | — |
| University of Miami Miller School of Medicine | Deerfield Beach | Florida | 33442 | — |
| Florida Cancer Specialists South | Fort Myers | Florida | 33916 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Baptist Cancer Institute | Jacksonville | Florida | 32207 | — |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | — |
| Tallahassee Memorial HealthCare | Tallahassee | Florida | 32308 | — |
| Peachtree Hematology Oncology Consultants, PC | Atlanta | Georgia | 30318 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Georgia Cancer Specialists Clinic | Atlanta | Georgia | 30341 | — |
| Northwest Georgia Oncology Centers P.C. | Marietta | Georgia | 30060 | — |
| Summit Cancer Care, PC-Savannah | Savannah | Georgia | 31405 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Ingalis Memorial Hospital | Harvey | Illinois | 60426 | — |
| Illinois CancerCare | Peoria | Illinois | 60615 | — |
| Orchard Healthcare Research Inc. | Skokie | Illinois | 60077 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Lafayette General Medical Center | Lafayette | Louisiana | 70503 | — |
| Hematology and Oncology Specialists | Marrero | Louisiana | 70072 | — |
| Louisiana State University Health New Orleans | New Orleans | Louisiana | 70112 | — |
| Oschner Medical Center | New Orleans | Louisiana | 70121 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21287-0013 | — |
| Frederick Memorial Hospital | Frederick | Maryland | 21701 | — |
| Holy Cross Hospital | Silver Spring | Maryland | 20902 | — |
| Virginia Piper Cancer Center | Minneapolis | Minnesota | 55407 | — |
| HCA Midwest Health | Kansas City | Missouri | 64132 | — |
| Washington University Dept of Oncology | St Louis | Missouri | 63110 | — |
| St John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Hunterdon Regional Cancer Center | Flemington | New Jersey | 08822 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Clinical Research Alliance, Inc. | Lake Success | New York | 11042 | — |
| ProHEALTH Care Associates | Lake Success | New York | 11042 | — |
| Beth Isreal Medical Center | New York | New York | 10011 | — |
| Weill Cornell Medical Center | New York | New York | 10021 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Novant Health | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Oncology Hematology Care | Cincinnati | Ohio | 45242 | — |
| Cleveland Clinic-Taussig Cancer Institute-R35 | Cleveland | Ohio | 44195 | — |
| Signal Point Clinical Research Center, LLC | Middletown | Ohio | 45042 | — |
| Mercy Clinic of Oklahoma | Oklahoma City | Oklahoma | 73120 | — |
| Oregon Health and Science University | Beaverton | Oregon | 97006 | — |
| St Mary Medical Center | Langhorne | Pennsylvania | 19047 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Guthrie Clinical Research | Sayre | Pennsylvania | 18840 | — |
| Charleston Hematology Oncology Associates (CHOA) | Charleston | South Carolina | 29414 | — |
| Chattanooga Oncology Hematology Associates | Chattanooga | Tennessee | 37404 | — |
| Center for Biomedical Research, LLC | Knoxville | Tennessee | 37909 | — |
| Sarah Cannon Cancer Center | Nashville | Tennessee | 37203 | — |
| Oncology Hematology Consultants PA | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| Texas Tech University Health Sciences Center | Lubbock | Texas | 79430 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 69 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01997333, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 8, 2019 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01997333 live on ClinicalTrials.gov.