Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT
Public ClinicalTrials.gov record NCT02036970. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Dose-Ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with pulmonary hypertension to determine the recommended dose range, evaluate the change from baseline in 6-minute walk distance (6MWD) and determine the effect of Bardoxolone methyl in pulmonary hypertension associated with connective tissue disease, interstitial lung disease, and idiopathic etiologies, including subsets of patients with WHO Group III or WHO Group V PH following 16 weeks of study participation.
Study identification
- NCT ID
- NCT02036970
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 166 participants
Conditions and interventions
Conditions
- Pulmonary Arterial Hypertension
- Pulmonary Hypertension
- Interstitial Lung Disease
- Idiopathic Interstitial Pneumonia
- Idiopathic Pulmonary Fibrosis
- Sarcoidosis
- Respiratory Bronchiolitis Associated Interstitial Lung Disease
- Desquamative Interstitial Pneumonia
- Cryptogenic Organizing Pneumonia
- Acute Interstitial Pneumonitis
- Idiopathic Lymphoid Interstitial Pneumonia
- Idiopathic Pleuroparenchymal Fibroelastosis
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2014 (Actual)
- Primary completion
- Jan 19, 2018 (Actual)
- Completion
- May 16, 2018 (Actual)
- Last update posted
- Jun 10, 2025
2014 – 2018
United States locations
- U.S. sites
- 30
- U.S. states
- 14
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center, Phoenix Advanced Lung Disease Institute | Phoenix | Arizona | 85004 | — |
| Arizona Pulmonary Specialists | Phoenix | Arizona | 85012 | — |
| Cedars Sinai Medical Center | Beverly Hills | California | 90211 | — |
| VA Healthcare System of Greater Los Angeles | Los Angeles | California | 90073 | — |
| University of California Davis Medical Center - Division of Pulmonary and Critical Care | Sacramento | California | 95817 | — |
| Harbor - UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado Denver - Division of Pulmonary Sciences | Aurora | Colorado | 80045 | — |
| South Denver Cardiology Associates, P.C | Littleton | Colorado | 80120 | — |
| Georgetown University Medical Center - Department of Rheumatology | Washington D.C. | District of Columbia | 20007 | — |
| Cleveland Clinic of Florida | Weston | Florida | 33331 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Maine Medical Center - Division of Pulmonary and Critical Care Medicine | Portland | Maine | 04102 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| Mount Sinai, Beth Israel Medical Center | New York | New York | 10003 | — |
| Weill Cornell Medical Center | New York | New York | 10021 | — |
| University of Rochester - University of Rochester Medical Center | Rochester | New York | 14642 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati - Department of Internal Medicine Pulmonary, Critical Care & Sleep Medicine | Cincinnati | Ohio | 45267 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| BreatheAmerica El Paso, Inc. | El Paso | Texas | 79912 | — |
| Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| The University of Texas - Health Science Center & Medical School at Houston | Houston | Texas | 77030 | — |
| University of Texas Houston - Division of Rheumatology and Clinical Immunogenetics | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02036970, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 10, 2025 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02036970 live on ClinicalTrials.gov.