Radium-223 Dichloride and Abiraterone Acetate Compared to Placebo and Abiraterone Acetate for Men With Cancer of the Prostate When Medical or Surgical Castration Does Not Work and When the Cancer Has Spread to the Bone, Has Not Been Treated With Chemotherapy and is Causing no or Only Mild Symptoms
Public ClinicalTrials.gov record NCT02043678. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomized, Double-blind, Placebo-controlled Trial of Radium-223 Dichloride in Combination With Abiraterone Acetate and Prednisone/Prednisolone in the Treatment of Asymptomatic or Mildly Symptomatic Chemotherapy-naïve Subjects With Bone Predominant Metastatic Castration-resistant Prostate Cancer(CRPC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To determine if the addition of radium-223 dichloride to standard treatment is able to prolong life and to delay events specific for prostate cancer which has spread to the bone, such as painful fractures or bone pain which needs to be treated with an X-ray machine.
Study identification
- NCT ID
- NCT02043678
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 806 participants
Conditions and interventions
Conditions
Interventions
- Radium-223 dichloride (Xofigo, BAY88-8223) Drug
- Matching placebo (normal saline) Drug
- Abiraterone Drug
- Prednisone/Prednisolone Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2014 (Actual)
- Primary completion
- Feb 15, 2018 (Actual)
- Completion
- Feb 8, 2024 (Actual)
- Last update posted
- Feb 19, 2025
2014 – 2024
United States locations
- U.S. sites
- 29
- U.S. states
- 21
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Anchorage | Alaska | 99503 | — |
| Not listed | Tucson | Arizona | 85718 | — |
| Not listed | Oceanside | California | 92056 | — |
| Not listed | Denver | Colorado | 80211 | — |
| Not listed | Washington D.C. | District of Columbia | 20007-2113 | — |
| Not listed | Fort Myers | Florida | 33901 | — |
| Not listed | Atlanta | Georgia | 30322 | — |
| Not listed | Jeffersonville | Indiana | 47130 | — |
| Not listed | New Orleans | Louisiana | 70112 | — |
| Not listed | Baltimore | Maryland | 21201 | — |
| Not listed | Rockville | Maryland | 20850 | — |
| Not listed | Towson | Maryland | 21204 | — |
| Not listed | Boston | Massachusetts | 02114-2696 | — |
| Not listed | Burlington | Massachusetts | 1805 | — |
| Not listed | Detroit | Michigan | 48202 | — |
| Not listed | Traverse City | Michigan | 49684 | — |
| Not listed | St Louis | Missouri | 63110 | — |
| Not listed | Omaha | Nebraska | 68130 | — |
| Not listed | Las Vegas | Nevada | 89169 | — |
| Not listed | Hackensack | New Jersey | 7601 | — |
| Not listed | Poughkeepsie | New York | 12601 | — |
| Not listed | Syracuse | New York | 13210 | — |
| Not listed | Bala-Cynwyd | Pennsylvania | 19004 | — |
| Not listed | Pittsburgh | Pennsylvania | 15215 | — |
| Not listed | Pittsburgh | Pennsylvania | 15240 | — |
| Not listed | Norfolk | Virginia | 23502 | — |
| Not listed | Seattle | Washington | 98109-1023 | — |
| Not listed | Spokane | Washington | 99208-1129 | — |
| Not listed | Wheeling | West Virginia | 26003 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 134 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02043678, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 19, 2025 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02043678 live on ClinicalTrials.gov.