Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

ClinicalTrials.gov ID: NCT02074839

Public ClinicalTrials.gov record NCT02074839. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 7, 2026, 9:04 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

Study identification

NCT ID: NCT02074839
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Institut de Recherches Internationales Servier; Other
Enrollment: 291 participants

Conditions and interventions

Conditions

Interventions

AG-120 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 28, 2014
Primary completion: Feb 28, 2026
Completion: Feb 28, 2026
Last update posted: Jun 7, 2025

2014 – 2026

United States locations

U.S. sites: 26
U.S. states: 18
U.S. cities: 24

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35294	Active, not recruiting
Mayo Clinic-AZ	Phoenix	Arizona	85259	Terminated
City of Hope	Duarte	California	91010	Active, not recruiting
University of California-Los Angeles	Los Angeles	California	90095	Terminated
University of California-San Francisco	San Francisco	California	94143	Terminated
University of Colorado Denver	Aurora	Colorado	80045	Terminated
Mayo Clinic-Jacksonville	Jacksonville	Florida	32224	Terminated
University of Miami	Miami	Florida	33136	Terminated
Moffit Cancer Center	Tampa	Florida	33612	Active, not recruiting
Emory University	Atlanta	Georgia	30322	Active, not recruiting
Northwestern University Medical Hospital	Chicago	Illinois	60611	Terminated
John Hopkins Cancer Center	Baltimore	Maryland	21287	Active, not recruiting
Massachusetts General Hospital	Boston	Massachusetts	02214	Terminated
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Terminated
Karmanos Cancer Center	Detroit	Michigan	48201	Terminated
Washington University	St Louis	Missouri	63110	Terminated
Memorial Sloan Kettering Cancer Center	New York	New York	10021	Active, not recruiting
Cornell Cancer Center	New York	New York	10065	Terminated
Duke Cancer Center	Durham	North Carolina	27705	Terminated
Cleveland Clinic	Cleveland	Ohio	44124	Withdrawn
Ohio State University	Columbus	Ohio	43210	Terminated
Oregon Health and Science University	Portland	Oregon	97239	Terminated
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Sarah Cannon Research Institute	Nashville	Tennessee	37203	Terminated
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02074839, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 7, 2025 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT02074839 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →