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Completed Phase 1Phase 2 Interventional Results available

Ibrutinib in Combination With Lenalidomide and Rituximab in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

ClinicalTrials.gov ID: NCT02077166

Public ClinicalTrials.gov record NCT02077166. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Nov 9, 2026, 10:21 AM EST

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Official title

A Multicenter Open-Label Phase 1b/2 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Lenalidomide and Rituximab in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This Phase 1b/2 study is designed to assess the safety and efficacy of ibrutinib in combination with lenalidomide and rituximab in subjects with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) not eligible for transplant.

Study identification

NCT ID
NCT02077166
Recruitment status
Completed
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
Pharmacyclics LLC.
Industry
Enrollment
138 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 13, 2014 (Actual)
Primary completion
Dec 17, 2020 (Actual)
Completion
Dec 17, 2020 (Actual)
Last update posted
Feb 4, 2022

2014 – 2020

United States locations

U.S. sites
22
U.S. states
16
U.S. cities
21
Facility City State ZIP Site status
University of Alabama Birmingham Alabama 35294 —
Banner MD Anderson Cancer Center Gilbert Arizona 85234 —
Cedar Sinai Medical Center Los Angeles California 90048 —
UCLA Medical Center Los Angeles California 90095 —
University of Florida Gainesville Florida 32610 —
Rush University Medical Center Chicago Illinois 60612 —
University of Iowa Iowa City Iowa 52242 —
Tulane Medical Center New Orleans Louisiana 70112 —
Karmanos Cancer Institute Detroit Michigan 48201 —
Comprehensive Cancer Center of Nevada Las Vegas Nevada 89169 —
Hackensack University Medical Center Hackensack New Jersey 07601 —
Summit Medical Group Morristown New Jersey 07960 —
Weill Cornell Medical Center New York New York 10065 —
Levine Cancer Institute Charlotte North Carolina 28204 —
University of Cincinnati Health Barrett Center Cincinnati Ohio 45267 —
Mid-Ohio Oncology/ Hematology Columbus Ohio 43219 —
University of TN Medical Center Knoxville Tennessee 37920 —
Vanderbilt Ingram Cancer Center Nashville Tennessee 37232 —
Baylor Charles Sammons Cancer Center Dallas Texas 75246 —
The University of Texas, MD Anderson Cancer Center Houston Texas 77030 —
Medical Oncology Associates, PS Spokane Washington 99208 —
Northwest Medical Specialities, PLLC Tacoma Washington 98405 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02077166, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Feb 4, 2022 · Synced Nov 9, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02077166 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →