A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors
Public ClinicalTrials.gov record NCT02099058. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Phase 1/1b, Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced solid tumors likely to express c-Met. Enrollment is closed for the monotherapy arms, Arm A, and Arm D.
Study identification
- NCT ID
- NCT02099058
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 237 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 15, 2014 (Actual)
- Primary completion
- Aug 2026 (Estimated)
- Completion
- Aug 2026 (Estimated)
- Last update posted
- Aug 14, 2025
2014 – 2026
United States locations
- U.S. sites
- 21
- U.S. states
- 13
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scottsdale Healthcare /ID# 123761 | Scottsdale | Arizona | 85258-4566 | — |
| City of Hope /ID# 153759 | Duarte | California | 91010 | — |
| University of California, Los Angeles /ID# 148295 | Los Angeles | California | 90095 | — |
| UC Irvine /ID# 165107 | Orange | California | 92868 | — |
| University of California, Davis Comprehensive Cancer Center /ID# 129805 | Sacramento | California | 95817 | — |
| Univ of Colorado Cancer Center /ID# 123759 | Aurora | Colorado | 80045 | — |
| The University of Chicago Medical Center /ID# 136995 | Chicago | Illinois | 60637-1443 | — |
| Ingalls Memorial Hosp /ID# 165876 | Harvey | Illinois | 60426 | — |
| Massachusetts General Hospital /ID# 129804 | Boston | Massachusetts | 02114 | — |
| Dana-Farber Cancer Institute /ID# 168782 | Boston | Massachusetts | 02215 | — |
| Duplicate_Henry Ford Health System /ID# 149857 | Detroit | Michigan | 48202 | — |
| Herbert Herman Cancer Center /ID# 149858 | Lansing | Michigan | 48912 | — |
| Washington University-School of Medicine /ID# 143798 | St Louis | Missouri | 63110 | — |
| Summit Medical Group-Florham Park /ID# 217651 | Florham Park | New Jersey | 07932-1049 | — |
| Northwell Health - Monter Cancer Center /ID# 218170 | Lake Success | New York | 11042 | — |
| Montefiore Medical Park at Eastchester /ID# 218445 | The Bronx | New York | 10461 | — |
| Duke Cancer Center /ID# 123763 | Durham | North Carolina | 27710-3000 | — |
| Tennessee Oncology, PLLC /ID# 129802 | Nashville | Tennessee | 37203 | — |
| Mary Crowley Cancer Research /ID# 123760 | Dallas | Texas | 75230 | — |
| University of Texas MD Anderson Cancer Center /ID# 154648 | Houston | Texas | 77030 | — |
| Virginia Cancer Specialists - Fairfax /ID# 165708 | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02099058, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 14, 2025 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02099058 live on ClinicalTrials.gov.