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Completed Phase 2 Interventional Results available

PNT2258 for Treatment of Patients With r/r DLBCL (Wolverine)

ClinicalTrials.gov ID: NCT02226965

Public ClinicalTrials.gov record NCT02226965. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 2:44 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Study of PNT2258 in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. It is a multi-center, nonrandomized, open label, phase II investigation of PNT2258 to characterize anti-tumor activity and collect safety data on patients with relapsed or refractory (r/r) diffuse large B-cell lymphoma.

Study identification

NCT ID
NCT02226965
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Enrollment
45 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 2014 (Actual)
Primary completion
Jul 11, 2016 (Actual)
Completion
Aug 22, 2018 (Actual)
Last update posted
Jun 29, 2023

2014 – 2018

United States locations

U.S. sites
26
U.S. states
17
U.S. cities
25
Facility City State ZIP Site status
Long Beach Memorial Medical Center Long Beach California 90806 —
University of Southern California Los Angeles California 90033 —
Colorado Blood and Cancer Institute Denver Colorado 80218 —
Lynn Cancer Institute Boca Raton Florida 33486 —
Bond Clinic, P.A. Winter Haven Florida 33880 —
Georgia Regents University Augusta Georgia 30912 —
Rush University Medical Center Chicago Illinois 60612 —
Horizon Oncology Research, Inc. Lafayette Indiana 47905 —
UHC Oncology Lafayette Louisiana 70506 —
Western Maryland Health System Cumberland Maryland 21502 —
Dana-Farber Cancer Institute Boston Massachusetts 02115 —
Mercy Health Saint Mary's Grand Rapids Michigan 49503 —
St. John Hospital and Medical Center Grosse Pointe Woods Michigan 48236 —
Michigan State University Lansing Michigan 48910 —
William Beaumont Hospital Royal Oak Michigan 48073 —
SUNY Upstate Medical University Syracuse New York 13210 —
Duke University Durham North Carolina 27710 —
Bon Secours Saint Francis Cancer Center Greenville South Carolina 29607 —
Avera Research Institute Sioux Falls South Dakota 57108 —
Baylor Research Institute Dallas Texas 75246 —
University of Texas Southwestern Medical Center Dallas Texas 75390 —
M.D. Anderson Cancer Center Houston Texas 77030 —
Tyler Hematology Oncology Tyler Texas 75701 —
Virginia Cancer Specialists Fairfax Virginia 22031 —
Peninsula Cancer Institute Newport News Virginia 23601 —
Medical Oncology Associates, PS Spokane Washington 99208 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02226965, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 29, 2023 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02226965 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →