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Active, not recruiting Phase 2 Interventional

Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

ClinicalTrials.gov ID: NCT02227251

Public ClinicalTrials.gov record NCT02227251. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 17, 2026, 4:46 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2b Open-label Study of Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A multicenter, open-label Phase 2b study of selinexor (KPT-330) in participants with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have no therapeutic options of demonstrated clinical benefit.

Study identification

NCT ID
NCT02227251
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Karyopharm Therapeutics Inc
Industry
Enrollment
244 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 2014 (Actual)
Primary completion
Dec 2026 (Estimated)
Completion
Dec 2026 (Estimated)
Last update posted
Oct 1, 2026

2014 – 2026

United States locations

U.S. sites
23
U.S. states
13
U.S. cities
19
Facility City State ZIP Site status
UACC Arizona Tucson Arizona 85704 —
University of California San Francisco San Francisco California — —
University of California Los Angeles (UCLA) Santa Monica California 90404 —
Boca Raton Cancer Research Medical Center Plantation Florida — —
University of Chicago Chicago Illinois 60637 —
Robert H. Lurie Comprehensive Cancer Center/Northwestern University Chicago Illinois — —
Norton Cancer Institute Louisville Kentucky 40241 —
Dana Farber Cancer Institute Boston Massachusetts — —
Tufts Medical Center Boston Massachusetts — —
Lahey Clinic Burlington Massachusetts — —
University of Massachusetts Medical School Worcester Massachusetts — —
John Theurer Cancer Center at Hackensack University Medical Center Hackensack New Jersey — —
Clinical Research Alliance Lake Success New York — —
New York Presbyterian Hospital/ Cornell Medical College New York New York 10065 —
Stony Brook University Hospital Stony Brook New York 11794 —
Gabrail Cancer Center Canton Ohio 44718 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
University Hospitals Seidman Cancer Center Cleveland Ohio — —
University of Oklahoma Oklahoma City Oklahoma — —
Greenville Hospital System Greenville South Carolina 29605 —
MD Anderson Houston Texas 77030 —
Swedish Cancer Institute Seattle Washington 98104 —
Virginia Mason Hospital & Medical Center Seattle Washington — —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 152 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02227251, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 1, 2026 · Synced Oct 17, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02227251 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →