Selonsertib in Adults With Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT02234141. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Study of GS-4997 in Subjects With Pulmonary Arterial Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to evaluate the effect of selonsertib (GS-4997) on pulmonary vascular resistance (PVR), as measured by right heart catheterization (RHC) in adults with pulmonary arterial hypertension (PAH). The study will consist of a 24-week placebo-controlled treatment period and a long-term selonsertib treatment period. Participants completing the 24-week placebo-controlled period will be eligible to receive active treatment with selonsertib in the long-term treatment period.
Study identification
- NCT ID
- NCT02234141
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 151 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2014 (Type not available)
- Primary completion
- Apr 2016 (Actual)
- Completion
- Dec 2016 (Actual)
- Last update posted
- Apr 10, 2019
2014 – 2016
United States locations
- U.S. sites
- 24
- U.S. states
- 15
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama Medical Center | Mobile | Alabama | — | — |
| Advanced Lung Disease Institute | Phoenix | Arizona | — | — |
| Arizona Pulmonary Specialist, Ltd | Phoenix | Arizona | — | — |
| University of Arizona Clinical and Translational Science (CATS) Research Center | Tucson | Arizona | — | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | — | — |
| University of California, Davis | Sacramento | California | — | — |
| University of California, San Francisco | San Francisco | California | — | — |
| LA Biomedical Research Institute Harbor-UCLA Medical Center | Torrance | California | — | — |
| University of Colorado Cardiac and Vascular Center, Anschutz Inpatient Pavillion | Aurora | Colorado | — | — |
| The Emory Clinic | Atlanta | Georgia | — | — |
| University of Chicago Medicine | Chicago | Illinois | — | — |
| Boston University Medical Center | Boston | Massachusetts | — | — |
| Tufts Medical Center | Boston | Massachusetts | — | — |
| University of Michigan Health System | Ann Arbor | Michigan | — | — |
| University of Minnesota | Minneapolis | Minnesota | — | — |
| Mayo Clinic | Rochester | Minnesota | — | — |
| Washington University School of Medicine | St Louis | Missouri | — | — |
| Mary M. Parkes Center // University of Rochester Medical Center | Rochester | New York | — | — |
| Cleveland Clinic | Cleveland | Ohio | — | — |
| Martha Morehouse Medical Pavilion | Columbus | Ohio | — | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | — | — |
| UPMC Presbyterian Hospital | Pittsburgh | Pennsylvania | — | — |
| UT Southwestern Medical Center | Dallas | Texas | — | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02234141, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 10, 2019 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02234141 live on ClinicalTrials.gov.