Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry
Public ClinicalTrials.gov record NCT02271022. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the UPSTREAM Registry is to address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction)between ED (Emergency Department) arrival and diagnostic angiography in detail, by characterizing and following the ED and peri-ED use of advanced OAP (Oral Anti-Platelet) agents. In addition to exploring ED treatment patterns and success of both ischemic and bleeding risk stratification prior to definition of the coronary anatomy, data generated via the UPSTREAM registry will allow plausible attribution of ischemic and bleeding outcomes to pre-catheterization antiplatelet therapy in the management of NSTEMI. This registry further seeks to demonstrate that contemporary use of upstream ticagrelor is associated with an economically-sound utilization of hospital resources, and smooth transition of care into the outpatient, secondary prevention setting for the first 30 days after hospitalization. Finally, it will allow characterization of patient selection factors and processes for ticagrelor vs alternative OAP agents, carrying out that descriptive comparison through discharge. Patients transferred in to an UPSTREAM hospital are eligible for inclusion, but the timing for OAP agent administration and diagnostic catheterization begin with ED care at the first hospital.
Study identification
- NCT ID
- NCT02271022
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 17, 2015 (Actual)
- Primary completion
- Oct 31, 2019 (Actual)
- Completion
- Oct 31, 2019 (Actual)
- Last update posted
- Nov 3, 2020
2015 – 2019
United States locations
- U.S. sites
- 55
- U.S. states
- 26
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35233 | — |
| Research Site | Mobile | Alabama | 36688 | — |
| Research Site | Little Rock | Arkansas | 72211 | — |
| Research Site | Sacramento | California | 95812 | — |
| Research Site | Bridgeport | Connecticut | 06610 | — |
| Research Site | Hartford | Connecticut | 06102 | — |
| Research Site | Washington D.C. | District of Columbia | 20036 | — |
| Research Site | Gainesville | Florida | 32603 | — |
| Research Site | Hialeah | Florida | 33016 | — |
| Research Site | Miami | Florida | 33136 | — |
| Research Site | Tampa | Florida | 33606 | — |
| Research Site | Atlanta | Georgia | 30322 | — |
| Research Site | Macon | Georgia | 31217 | — |
| Research Site | Peoria | Illinois | 61614 | — |
| Research Site | Richmond | Indiana | 47374 | — |
| Research Site | Baltimore | Maryland | 20814 | — |
| Research Site | Baltimore | Maryland | 21215 | — |
| Research Site | Baltimore | Maryland | 21287 | — |
| Research Site | Boston | Massachusetts | 02115 | — |
| Research Site | Worcester | Massachusetts | 06105 | — |
| Research Site | Bloomfield | Michigan | 48323 | — |
| Research Site | Grand Blanc | Michigan | 48439 | — |
| Research Site | Royal Oak | Michigan | 48073 | — |
| Research Site | Duluth | Minnesota | 55805 | — |
| Research Site | Saint Paul | Minnesota | 55101 | — |
| Research Site | Kansas City | Missouri | 64106 | — |
| Research Site | Kansas City | Missouri | 64111 | — |
| Research Site | Kansas City | Missouri | 64116 | — |
| Research Site | Springfield | Missouri | 65807 | — |
| Research Site | Camden | New Jersey | 08103 | — |
| Research Site | Flemington | New Jersey | 08822 | — |
| Research Site | Newark | New Jersey | 07102 | — |
| Research Site | Piscataway | New Jersey | 08854 | — |
| Research Site | Teaneck | New Jersey | 07666 | — |
| Research Site | Brooklyn | New York | 11215 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | New York | New York | 11235 | — |
| Research Site | Durham | North Carolina | 27710 | — |
| Research Site | Cleveland | Ohio | 44195 | — |
| Research Site | Oklahoma City | Oklahoma | 73135 | — |
| Research Site | Roseburg | Oregon | 97471 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Philadelphia | Pennsylvania | 19141 | — |
| Research Site | York and Ephrata | Pennsylvania | 17403 | — |
| Research Site | Memphis | Tennessee | 37920 | — |
| Research Site | Memphis | Tennessee | 38120 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | Galveston | Texas | 77550 | — |
| Research Site | McKinney | Texas | 75069 | — |
| Research Site | New Braunfels | Texas | 78132 | — |
| Research Site | Charlottesville | Virginia | 22903 | — |
| Research Site | Tacoma | Washington | 98405 | — |
| Research Site | Manitowoc | Wisconsin | 54221 | — |
| Research Site | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02271022, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 3, 2020 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02271022 live on ClinicalTrials.gov.