A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase
Public ClinicalTrials.gov record NCT02369653. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention Versus No Systemic Anticoagulant Prophylaxis During Induction Chemotherapy in Children With Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B Cell) Treated With Asparaginase
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the effect of a blood thinning drug called Apixaban versus no administration of a blood thinning drug, in preventing blood clots in children with leukemia or lymphoma. Patients must be receiving chemotherapy, including asparaginase, and have a central line (a catheter inserted for administration of medications and blood sampling)
Study identification
- NCT ID
- NCT02369653
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 512 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 1 Year to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 22, 2015 (Actual)
- Primary completion
- Jul 7, 2021 (Actual)
- Completion
- Jul 7, 2021 (Actual)
- Last update posted
- Mar 8, 2022
2015 – 2021
United States locations
- U.S. sites
- 64
- U.S. states
- 24
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children'S Hospital/Ctr. For Cancer & Blood Ctr. | Phoenix | Arizona | 85016 | — |
| City of Hope | Duarte | California | 91010 | — |
| Loma Linda University Cancer Center | Loma Linda | California | 92350 | — |
| Childrens Hospital Of La | Los Angeles | California | 90027 | — |
| Children'S Hospital Of Orange County | Orange | California | 92868 | — |
| Lucile Packard Children's Hospital (LPCH) | Palo Alto | California | 94304 | — |
| Rady Children'S Hospital - San Diego | San Diego | California | 92123-4282 | — |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06520 | — |
| Nemours / A. I. duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Golisano Childrens Hospital of Southwest Florida | Fort Myers | Florida | 33908 | — |
| Shands Hospital At University Of Florida | Gainesville | Florida | 32610-0298 | — |
| Nemours Children'S Clinic | Jacksonville | Florida | 32207 | — |
| Nemours Children'S Clinic - Orlando | Orlando | Florida | 32827 | — |
| Nemours Children'S Clinic-Pensacola | Pensacola | Florida | 32504 | — |
| All Childrens Hospital Specialty Physicians | St. Petersburg | Florida | 33701 | — |
| St. Marys Medical Center | West Palm Beach | Florida | 33407 | — |
| Childrens Healthcare Of Atlanta - E | Atlanta | Georgia | 30342 | — |
| Navicent Health Physician Group | Macon | Georgia | 31201 | — |
| St. Luke'S Mountain State Tumor Institute | Boise | Idaho | 83712 | — |
| Children'S Center For Cancer And Blood Diseases | Indianapolis | Indiana | 46260 | — |
| Blank Childrens Hospital | Des Moines | Iowa | 50309 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kentucky | Lexington | Kentucky | 40536-0293 | — |
| University Of Louisville | Louisville | Kentucky | 40202 | — |
| Childrens Hospital New Orleans | New Orleans | Louisiana | 70118 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Sinai Hospital Of Baltimore | Baltimore | Maryland | 21215 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| University Of Michigan Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Childrens Hospitals And Clinics Of Minnesota | Minneapolis | Minnesota | 55404 | — |
| University Of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| University Of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Valerie Fund Children's Center at St. Joseph's Children's Hospital | Paterson | New Jersey | 07503 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| University Of Rochester General Clinical Research Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Unv. Of Nc At Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Akron Children'S Hospital | Akron | Ohio | 44308 | — |
| Cincinnati Children'S Hospital Medical Center | Cincinnati | Ohio | 45229-3039 | — |
| University Hospitals | Cleveland | Ohio | 44106 | — |
| Nationwide Children'S Hospital | Columbus | Ohio | 43205 | — |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Childrens Hospital Of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Children's Hospital Of Pittsburgh Of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Children's Hospital at TriStar Centennial | Nashville | Tennessee | 37203 | — |
| Monroe Carell Jr Children'S Hosp. At Vanderbilt Tower | Nashville | Tennessee | 37232 | — |
| Dell Children'S Medical Center Of Central Texas | Austin | Texas | 78723 | — |
| Driscoll Children'S Hospital | Corpus Christi | Texas | 78411 | — |
| Texas Children's Cancer and Hematology Centers | Houston | Texas | 77030 | — |
| Children's Hospital of San Antonio | San Antonio | Texas | 78207 | — |
| University Hospital | San Antonio | Texas | 78284 | — |
| Scott & White - McLane Children's Specialty Clinic | Temple | Texas | 76502 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
| MultiCare Institute for Research & Innovation | Tacoma | Washington | 98405 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02369653, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 8, 2022 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02369653 live on ClinicalTrials.gov.