SNP-based Microdeletion and Aneuploidy RegisTry (SMART)
Public ClinicalTrials.gov record NCT02381457. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
SNP-based Microdeletion and Aneuploidy RegisTry
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This multi-center prospective observational study is designed to track birth outcomes and perinatal correlates to the Panorama prenatal screening test in the general population among ten thousand women who present clinically and elect Panorama microdeletion and aneuploidy screening as part of their routine care. The primary objective is to evaluate the performance of Single Nucleotide Polymorphism (SNP)-based Non Invasive Prenatal Testing (NIPT) for 22q11.2 microdeletion (DiGeorge syndrome) in this large cohort of pregnant women. This will be done by performing a review of perinatal medical records and obtaining biospecimens after birth to perform genetic diagnostic testing for 22q11.2 deletion. Results from the follow-up specimens will be compared to those obtained by the Panorama screening test to determine test performance. Specific test performance parameters will include: PPV, specificity, and sensitivity.
Study identification
- NCT ID
- NCT02381457
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 20,960 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 48 Years
- Sex
- Female
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2015
- Primary completion
- May 31, 2020
- Completion
- May 31, 2020
- Last update posted
- Jan 28, 2021
2015 – 2020
United States locations
- U.S. sites
- 16
- U.S. states
- 5
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California, San Francisco | San Francisco | California | 94158 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Virtua | Mount Laurel | New Jersey | 08054 | — |
| St. Peter's University | New Brunswick | New Jersey | 08901 | — |
| Complete Women's Healthcare | Garden City | New York | 11530 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Madonna Perinatal | Mineola | New York | 11501 | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| New York University | New York | New York | 10016 | — |
| Icahn School of Medicine Mt Sinai | New York | New York | 10029 | — |
| Columbia University | New York | New York | 10032 | — |
| Montefiore Medical Center | New York | New York | 10461 | — |
| Suffolk OB | Port Jefferson | New York | 11777 | — |
| North Austin Maternal Fetal Medicine | Austin | Texas | 78758 | — |
| Zeid Women's Health Center | Longview | Texas | 75601 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02381457, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 28, 2021 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02381457 live on ClinicalTrials.gov.