SNP-based Microdeletion and Aneuploidy RegisTry (SMART)

ClinicalTrials.gov ID: NCT02381457

Public ClinicalTrials.gov record NCT02381457. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 21, 2026, 5:19 AM EDT

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Official title

SNP-based Microdeletion and Aneuploidy RegisTry

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This multi-center prospective observational study is designed to track birth outcomes and perinatal correlates to the Panorama prenatal screening test in the general population among ten thousand women who present clinically and elect Panorama microdeletion and aneuploidy screening as part of their routine care. The primary objective is to evaluate the performance of Single Nucleotide Polymorphism (SNP)-based Non Invasive Prenatal Testing (NIPT) for 22q11.2 microdeletion (DiGeorge syndrome) in this large cohort of pregnant women. This will be done by performing a review of perinatal medical records and obtaining biospecimens after birth to perform genetic diagnostic testing for 22q11.2 deletion. Results from the follow-up specimens will be compared to those obtained by the Panorama screening test to determine test performance. Specific test performance parameters will include: PPV, specificity, and sensitivity.

Study identification

NCT ID: NCT02381457
Recruitment status: Completed
Study type: Observational
Phase: Not listed
Lead sponsor: Natera, Inc.; Industry
Enrollment: 20,960 participants

Conditions and interventions

Conditions

Interventions

Not listed

Eligibility (public fields only)

Age range: 18 Years to 48 Years
Sex: Female
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 2015 (Actual)
Primary completion: Jun 2020 (Actual)
Completion: Jun 2020 (Actual)
Last update posted: Jan 29, 2021

2015 – 2020

United States locations

U.S. sites: 16
U.S. states: 5
U.S. cities: 13

Facility	City	State	ZIP	Site status
University of California, San Francisco	San Francisco	California	94158	—
Cooper University Hospital	Camden	New Jersey	08103	—
Virtua	Mount Laurel	New Jersey	08054	—
St. Peter's University	New Brunswick	New Jersey	08901	—
Complete Women's Healthcare	Garden City	New York	11530	—
North Shore University Hospital	Manhasset	New York	11030	—
Madonna Perinatal	Mineola	New York	11501	—
Long Island Jewish Medical Center	New Hyde Park	New York	11040	—
New York University	New York	New York	10016	—
Icahn School of Medicine Mt Sinai	New York	New York	10029	—
Columbia University	New York	New York	10032	—
Montefiore Medical Center	New York	New York	10461	—
Suffolk OB	Port Jefferson	New York	11777	—
North Austin Maternal Fetal Medicine	Austin	Texas	78758	—
Zeid Women's Health Center	Longview	Texas	75601	—
University of Utah	Salt Lake City	Utah	84132	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02381457, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 29, 2021 · Synced Oct 21, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02381457 live on ClinicalTrials.gov.

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